Modeling of Cell Motion in Micro-Scale Hydrodynamic-Electrical Field

2009 ◽  
Vol 74 ◽  
pp. 139-142
Author(s):  
Ting Ye ◽  
Hua Li
Keyword(s):  
Stokes Equations ◽  
Elastic Shell ◽  
Practical Significance ◽  
Cell Manipulation ◽  
Navier Stokes ◽  
Phase System ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Maxwell Stress Tensor ◽  
Cell Motion

A modeling of two-phase system is presented for investigation of the cell motion and deformation in the microchannel subject to the mechanical and electrical coupled forces. In order to evaluate the mechanical force developed by cell membrane, it is treated as an incompressible and elastic shell with uniform thickness capable of shearing and bending deformation. Due to the irregular and complex cell configuration after deformation, the Maxwell stress tensor (MST) method is successfully employed to analyze the dielectrophoretic force. The modified particle binary level set (MPBLS) method is presented to accurately track the moving interface between the two phases, which is vital for a modeling of two-phase system. Afterwards the modified SIMPLER coupled with SIMPLEC is used to numerically solve the incompressible Navier-Stokes equations governing the entire flow field. On basis of the series of methods, the motion and deformation of red blood cell (RBC) in the microchannel under the mechanical and electrical forces are simulated to demonstrate the deformation process and the moving trajectory of RBC. The present study is not only of great value for deeper understanding of some diseases caused by cell abnormality, but also of practical significance for cell manipulation and separation.

Numerical Modeling of Evolution of Boundary Between Incompressible Gas and Liquid in Two-Dimensional Region

2006 ◽  
Vol 4 ◽  
pp. 224-236
Author(s):  
A.S. Topolnikov
Keyword(s):  
Numerical Modeling ◽  
Interphase Boundary ◽  
Incompressible Liquid ◽  
Stokes Equations ◽  
Numerical Code ◽  
Navier Stokes ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Incompressible Media ◽  
Good Agreement

The paper is devoted to numerical modeling of Navier–Stokes equations for incompressible media in the case, when there exist gas and liquid inside the rectangular calculation region, which are separated by interphase boundary. The set of equations for incompressible liquid accounting for viscous, gravitational and surface (capillary) forces is solved by finite-difference scheme on the spaced grid, for description of interphase boundary the ideology of Level Set Method is used. By developed numerical code the set of hydrodynamic problems is solved, which describe the motion of two-phase incompressible media with interphase boundary. As a result of numerical simulation the solutions are obtained, which are in good agreement with existing analytical and experimental solutions.

Numerical Investigation of the Coulter Principle in a Microfluidic Device

2013 ◽  
Author(s):  
Muheng Zhang ◽  
Yongsheng Lian
Keyword(s):  
Electric Field ◽  
Stokes Equations ◽  
Equations Of Motion ◽  
Navier Stokes ◽  
Working Mechanism ◽  
Navier Stokes Equations ◽  
Sheath Flow ◽  
Coulter Counters ◽  
Pass Through ◽  
Cell Motion

Coulter counters are analytical microfluidic instrument used to measure the size and concentration of biological cells or colloid particles suspended in electrolyte. The underlying working mechanism of Coulter counters is the Coulter principle which relies on the fact that when low-conductive cells pass through an electric field these cells cause disturbances in the measurement (current or voltage). Useful information about these cells can be obtained by analyzing these disturbances if an accurate correlation between the measured disturbances and cell characteristics. In this paper we use computational fluid dynamics method to investigate this correlation. The flow field is described by solving the Navier-Stokes equations, the electric field is represented by a Laplace’s equation in which the conductivity is calculated from the Navier-Stokes equations, and the cell motion is calculated by solving the equations of motion. The accuracy of the code is validated by comparing with analytical solutions. The study is based on a coplanar Coulter counter with three inlets that consist of two sheath flow inlet and one conductive flow inlet. The effects of diffusivity, cell size, sheath flow rate, and cell geometry are discussed in details. The impacts of electrode size, gap between electrodes and electrode location on the measured distribution are also studied.

NUMERICAL SIMULATION OF ISOTHERMAL AND THERMAL TWO-PHASE FLOWS USING PHASE-FIELD MODELING

2007 ◽  
Vol 18 (04) ◽  
pp. 536-545 ◽  
Author(s):  
NAOKI TAKADA ◽  
AKIO TOMIYAMA
Keyword(s):  
Phase Field ◽  
Stokes Equations ◽  
Density Ratio ◽  
Navier Stokes ◽  
Phase Field Modeling ◽  
Two Phase Flows ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Field Modeling ◽  
High Density Ratio

For interface-tracking simulation of two-phase flows in various micro-fluidics devices, we examined the applicability of two versions of computational fluid dynamics method, NS-PFM, combining Navier-Stokes equations with phase-field modeling for interface based on the van der Waals-Cahn-Hilliard free-energy theory. Through the numerical simulations, the following major findings were obtained: (1) The first version of NS-PFM gives good predictions of interfacial shapes and motions in an incompressible, isothermal two-phase fluid with high density ratio on solid surface with heterogeneous wettability. (2) The second version successfully captures liquid-vapor motions with heat and mass transfer across interfaces in phase change of a non-ideal fluid around the critical point.

scholarly journals Do the Volume-of-Fluid and the Two-Phase Euler Compete for Modeling a Spillway Aerator?

Water ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3092
Author(s):  
Lourenço Sassetti Mendes ◽  
Javier L. Lara ◽  
Maria Teresa Viseu
Keyword(s):  
Stokes Equations ◽  
Cost Benefit ◽  
Volume Of Fluid ◽  
Navier Stokes ◽  
Type Model ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Entrained Air ◽  
Computational Resources ◽  
Mesh Convergence

Spillway design is key to the effective and safe operation of dams. Typically, the flow is characterized by high velocity, high levels of turbulence, and aeration. In the last two decades, advances in computational fluid dynamics (CFD) made available several numerical tools to aid hydraulic structures engineers. The most frequent approach is to solve the Reynolds-averaged Navier–Stokes equations using an Euler type model combined with the volume-of-fluid (VoF) method. Regardless of a few applications, the complete two-phase Euler is still considered to demand exorbitant computational resources. An assessment is performed in a spillway offset aerator, comparing the two-phase volume-of-fluid (TPVoF) with the complete two-phase Euler (CTPE). Both models are included in the OpenFOAM® toolbox. As expected, the TPVoF results depend highly on the mesh, not showing convergence in the maximum chute bottom pressure and the lower-nappe aeration, tending to null aeration as resolution increases. The CTPE combined with the k–ω SST Sato turbulence model exhibits the most accurate results and mesh convergence in the lower-nappe aeration. Surprisingly, intermediate mesh resolutions are sufficient to surpass the TPVoF performance with reasonable calculation efforts. Moreover, compressibility, flow bulking, and several entrained air effects in the flow are comprehended. Despite not reproducing all aspects of the flow with acceptable accuracy, the complete two-phase Euler demonstrated an efficient cost-benefit performance and high value in spillway aerated flows. Nonetheless, further developments are expected to enhance the efficiency and stability of this model.

Discussion on Clustering Effects in Vertical Gas-Particle Flows

2000 ◽  
Author(s):  
Eivind Helland ◽  
Rene Occelli ◽  
Lounes Tadrist
Keyword(s):  
Gas Phase ◽  
Stokes Equations ◽  
Lagrangian Approach ◽  
Inelastic Collisions ◽  
Navier Stokes ◽  
Coupling Term ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Drag Forces ◽  
Particle Flows

Abstract Simulations of 2D gas-particle flows in a vertical riser using a mixed Eulerian-Lagrangian approach are addressed. The model for the interstitial gas phase is based on the Navier-Stokes equations for two-phase flow with a coupling term between the gas and solid phases due to drag forces. The motion of particles is treated by a Lagrangian approach and the particles are assumed to interact through binary, instantaneous, non-frontal, inelastic collisions with friction. In this paper different particle clustering effects in the gas-particle flow is investigated.

scholarly journals Simulating two-phase flows with thermodynamically consistent energy stable Cahn-Hilliard Navier-Stokes equations on parallel adaptive octree based meshes

2020 ◽  
Vol 419 ◽  
pp. 109674
Author(s):  
Makrand A. Khanwale ◽  
Alec D. Lofquist ◽  
Hari Sundar ◽  
James A. Rossmanith ◽  
Baskar Ganapathysubramanian
Keyword(s):  
Stokes Equations ◽  
Navier Stokes ◽  
Two Phase Flows ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Energy Stable

scholarly journals CLSVOF Method to Study the Formation Process of Taylor Cone in Crater-Like Electrospinning of Nanofibers

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Yong Liu ◽  
Jia Li ◽  
Yu Tian ◽  
Xia Yu ◽  
Jian Liu ◽  
...  
Keyword(s):  
Viscous Liquid ◽  
Formation Process ◽  
Stokes Equations ◽  
Taylor Cone ◽  
Computational Method ◽  
Navier Stokes ◽  
Two Phase ◽  
Navier Stokes Equations ◽  
Cone Formation ◽  
Computational Fluid Dynamics Cfd

The application of two-phase computational fluid dynamics (CFD) for simulating crater-like Taylor cone formation dynamics in a viscous liquid is a challenging task. An interface coupled level set/volume-of-fluid (CLSVOF) method and the governing equations based on Navier-Stokes equations were employed to simulate the crater-like Taylor cone formation process. The computational results of the dynamics of crater-like Taylor cone slowly formed on a free liquid surface produced by a submerged nozzle in a viscous liquid were presented in this paper. Some experiments with different air pressures were carried out to evaluate the simulation results. The results from both CFD and experimental observations were compared and analyzed. The numerical results were consistent with the experimental results. Our study showed that the CLSVOF method gave convincing results, and the computational method is robust to extreme variations in interfacial topology.

Modeling of Particulate Pressure in the Frame of Mesoscopic Eulerian Formalism for Compressible Reactive Dispersed Two-Phase Flows

2006 ◽  
Author(s):  
M. Simoes ◽  
O. Simonin
Keyword(s):  
Stokes Equations ◽  
Flow Region ◽  
Navier Stokes ◽  
Two Phase Flows ◽  
Two Phase ◽  
Specific Flow ◽  
Navier Stokes Equations ◽  
Rocket Motors ◽  
Eulerian Approach ◽  
Liquid Rocket

In space propulsion, compressible reactive dispersed two-phase flows are investigated in order to predict the behavior of solid or liquid rocket motors. In the frame of full Eulerian approach, physical modeling of aerodynamic flows in such motors is performed resolving unsteady compressible Navier-Stokes equations for both phases. However, numerical simulations performed on a simple axisymmetric motor have pointed out a flaw of this basic Eulerian approach. Indeed, the variance of the particle velocity distribution is not accounted for, leading to unrealistic accumulations of particles in some specific flow region. To correct this shortcoming, we have developed an advanced Eulerian model based on a statistical approach in the framework of the Mesoscopic Eulerian Formalism (MEF).

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