DNA-Coatings: Bioactive Properties and Effects on Osteoblast-Like Cells
2007 ◽
Vol 361-363
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pp. 605-608
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Keyword(s):
The aim of this study was to evaluate potential effects of DNA-coatings on calcium phosphate (CaP) nucleation from simulated body fluids (SBF) and subsequently the effects of DNA-coatings and SBF-immersed DNA coatings on the behavior of osteoblast-like cells. DNAcoatings demonstrated to enhance the nucleation and deposition of CaP from SBF compared to titanium controls. The behavior of osteoblast-like cells was affected on SBF-immersed DNAcoatings, showing an increased deposition of the extracellular matrix protein osteocalcin compared to titanium controls. These results indicate bone-bonding capacity of DNA-coatings, which needs to be confirmed using future animal experiments.
2002 ◽
Vol 267
(4)
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pp. 440-446
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Keyword(s):
2004 ◽
Vol 29
(1)
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pp. 52-56
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2000 ◽
Vol 275
(6)
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pp. 3999-4006
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