In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

2008 ◽  
Vol 396-398 ◽  
pp. 583-586
Author(s):  
Pierre Layrolle ◽  
Serge Baroth ◽  
Eric Goyenvalle ◽  
Eric Aguado ◽  
Françoise Moreau ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Healing ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Submicron Particles ◽  
Bone Filler ◽  
Osteoclastic Resorption ◽  
Tcp Phases

An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.

In Vivo Demonstration of 2 Types of Microporosity on the Kinetic of Bone Ingrowth and Biphasic Calcium Phosphate Bioceramics Resorption

2007 ◽  
Vol 361-363 ◽  
pp. 1233-1236 ◽  
Author(s):  
Oliver Malard ◽  
Helene Gautier ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Critical Size ◽  
Bone Ingrowth ◽  
Bone Substitutes ◽  
High Porosity ◽  
Critical Size Defects ◽  
Significant Difference ◽  
Kinetics Of

Microporosity and granules size are important parameters for the development of suspension, composites and injectable bone substitutes. In this experimental study performed in a rat bone model of critical size defects, were have determined the kinetics of bioceramic resorption and bone ingrowth. Two kinds of granules (1mm in diameter) of Biphasic Calcium Phosphate BCP (60/40 HA/TCP ratio) with 20% and 40% microporosity of less of 5 microns in size, were used. Higher bone ingrowth was observed for low porosity (LP) at 3 weeks versus high porosity (HP); the contrary was measured after 6 weeks. About the kinetics of BCP resorption, significant difference between the 2 porosities was noticed, the higher for high microporosity. High porosity on time, promotes more bone ingrowth at the expense of the bioceramic than lower microporosity.

scholarly journals Biphasic Calcium Phosphate Biomaterials: Stem Cell-Derived Osteoinduction or In Vivo Osteoconduction? Novel Insights in Maxillary Sinus Augmentation by Advanced Imaging

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2159
Author(s):  
Giovanna Iezzi ◽  
Antonio Scarano ◽  
Luca Valbonetti ◽  
Serena Mazzoni ◽  
Michele Furlani ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Maxillary Sinus ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphates ◽  
Three Dimensional ◽  
Sinus Augmentation ◽  
Native Bone ◽  
Maxillary Sinus Augmentation ◽  
Posterior Maxilla

Maxillary sinus augmentation is often necessary prior to implantology procedure, in particular in cases of atrophic posterior maxilla. In this context, bone substitute biomaterials made of biphasic calcium phosphates, produced by three-dimensional additive manufacturing were shown to be highly biocompatible with an efficient osteoconductivity, especially when combined with cell-based tissue engineering. Thus, in the present research, osteoinduction and osteoconduction properties of biphasic calcium-phosphate constructs made by direct rapid prototyping and engineered with ovine-derived amniotic epithelial cells or amniotic fluid cells were evaluated. More in details, this preclinical study was performed using adult sheep targeted to receive scaffold alone (CTR), oAFSMC, or oAEC engineered constructs. The grafted sinuses were explanted at 90 days and a cross-linked experimental approach based on Synchrotron Radiation microCT and histology analysis was performed on the complete set of samples. The study, performed taking into account the distance from native surrounding bone, demonstrated that no significant differences occurred in bone regeneration between oAEC-, oAFMSC-cultured, and Ctr samples and that there was a predominant action of the osteoconduction versus the stem cells osteo-induction. Indeed, it was proven that the newly formed bone amount and distribution decreased from the side of contact scaffold/native bone toward the bulk of the scaffold itself, with almost constant values of morphometric descriptors in volumes more than 1 mm from the border.

Biocompatibility of Surface-Modified Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite in vitro and in vivo

2010 ◽  
Vol 26 (8) ◽  
pp. 754-758 ◽  
Author(s):  
Weizhong Yang ◽  
Guangfu Yin ◽  
Dali Zhou ◽  
Jianwen Gu ◽  
Yadong Li ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Surface Modified

Macro/Microporous Biphasic Calcium Phosphate Cylinders and Resorbable Collagen Membranes for Guided Bone Growth

2007 ◽  
Vol 361-363 ◽  
pp. 439-442
Author(s):  
Borhane H. Fellah ◽  
Said Kimakhe ◽  
G. Daculsi ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Collagen Membrane ◽  
Calcium Phosphate Ceramic ◽  
Collagen Membranes ◽  
Large Bone ◽  
Empty Control ◽  
Large Bone Defects

This study aims at evaluating bone growth in critical-sized femoral defects of rats filled with macro micro porous biphasic calcium phosphate ceramic (MBCP) cylinders surrounded or not by a resorbable collagen membrane. Femoral defects left empty (control) exhibited partial bone ingrowths after 3 and 6 weeks and were completely healed at 12 weeks. The defects filled with the collagen membranes appeared partially healed suggesting that the membranes constraint bone ingrowth. Bone formation occurred around the collagen membrane which partially degraded over time. In the MBCP/membrane group, bone has grown inside the macro pores of the MBCP cylinders. Bone ingrowth was more rapid and abundant in the defects filled with MBCP alone. The combination MBCP/collagen membrane may be beneficial for the reconstruction of large bone defects without using repetitive surgeries and autologous bone grafting.

Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation

2020 ◽  
Vol 15 (5) ◽  
pp. 055038
Author(s):  
Sirirat T. Rattanachan ◽  
Nuan La-ong Srakaew ◽  
Paritat Thaitalay ◽  
Oranich Thongsri ◽  
Rawee Dangviriyakul ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Bone Cement

In vivo evaluation of interactions between biphasic calcium phosphate (BCP)-niobium pentoxide (Nb2O5) nanocomposite and tissues using a rat critical-size calvarial defect model

2020 ◽  
Vol 31 (8) ◽  
Author(s):  
Helio de Jesus Kiyochi Junior ◽  
Aline Gabriela Candido ◽  
Taiana Gabriela Moretti Bonadio ◽  
José Adauto da Cruz ◽  
Mauro Luciano Baesso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Critical Size ◽  
Niobium Pentoxide ◽  
Calvarial Defect ◽  
Defect Model ◽  
In Vivo Evaluation

Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth

Biomaterials ◽  
1998 ◽  
Vol 19 (1-3) ◽  
pp. 133-139 ◽  
Author(s):  
Olivier Gauthier ◽  
Jean-Michel Bouler ◽  
Eric Aguado ◽  
Paul Pilet ◽  
Guy Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Calcium Phosphate Ceramics
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