A PDMS Micropump for Implantable Drug Delivery Application

This paper presents an integrated magnetic PDMS micropump for implantable drug delivery application. The micropump mainly consists of two structural PDMS layers: a PDMS functional layer that incorporates microchannels, a pump chamber and two planar check valves into a single layer, allowing for simple design and easy system integration, and the other PDMS membrane layer covering the pump chamber and holding a thin electroplated permalloy piece on top for magnetic actuation. The micropump can be driven by the interaction between the ferromagnetic permalloy and an external electromagnet, providing a remote and wireless operation method. Test results demonstrate that this micropump is able to produce a maximal flow rate of 0.15 μL/min at the driving frequency of 2 Hz with a volume resolution of approximately 1 nL per stroke, promising its application in various implantable biomedical systems.

Download Full-text

A MEMS-Based PDMS Micropump Utilizing Electromagnetic Actuation and Planar In-Contact Check Valves

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.139-141.1574 ◽

2010 ◽

Vol 139-141 ◽

pp. 1574-1577 ◽

Cited By ~ 1

Author(s):

Jun Hui Ni ◽

Bei Zhi Li ◽

Jian Guo Yang

Keyword(s):

Flow Rate ◽

System Integration ◽

Low Cost ◽

Check Valve ◽

Driving Frequency ◽

Reliable Operation ◽

Electromagnetic Actuation ◽

Functional Layer ◽

Flow Channels ◽

Potential Use

This paper presents a novel low-cost poly(dimethylsiloxane) (PDMS) micropump with simple planar design featuring use of compliant in-contact check valves for reliable operation and easy system integration. The micropump mainly consists of two PDMS functional layers: one through-opening layer incorporating the planar in-contact check valves, pump chamber and flow channels, and the other thin membrane layer covering the chamber with a miniature permanent magnet on top for actuation. A special clamping molding technique was used to fabricate the through-opening functional layer, with which the flap-stopper based planar check valve was manipulated to contact each other enabling the minimized leakage flow. The micropump was then characterized by investigating the dependence of pumping flow rate on the driving frequency and backpressure. Testing results exhibit that the micropump is able to produce a flow rate at least of 3.0 μL/min, and work reliably against a backpressure of 1900 Pa, demonstrating the feasibility of this micropump for potential use in various lab-on-a-chip systems.

Download Full-text

A significant role of permeability on blood flow for hybrid nanofluid through bifurcated stenosed artery: Drug delivery application

Computer Methods and Programs in Biomedicine ◽

10.1016/j.cmpb.2019.105248 ◽

2020 ◽

Vol 187 ◽

pp. 105248 ◽

Cited By ~ 4

Author(s):

Iqra Shahzadi ◽

S. Bilal

Keyword(s):

Drug Delivery ◽

Blood Flow ◽

Significant Role ◽

Hybrid Nanofluid ◽

Drug Delivery Application ◽

Stenosed Artery

Download Full-text

Sonochemical synthesis and swelling behavior of Fe3O4 nanocomposite based on poly(acrylamide-co-acrylic acid) hydrogel for drug delivery application

Journal of Polymer Research ◽

10.1007/s10965-020-02382-0 ◽

2021 ◽

Vol 28 (2) ◽

Author(s):

Rajabali Ebrahimi ◽

Ghasem Rezanejade Bardajee

Keyword(s):

Drug Delivery ◽

Acrylic Acid ◽

Swelling Behavior ◽

Sonochemical Synthesis ◽

Drug Delivery Application ◽

Poly Acrylamide

Download Full-text

Drug delivery applications of poly-γ-glutamic acid

Future Journal of Pharmaceutical Sciences ◽

10.1186/s43094-021-00280-w ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Olalekan A. Balogun-Agbaje ◽

Olubusola A. Odeniyi ◽

Michael A. Odeniyi

Keyword(s):

Drug Delivery ◽

Glutamic Acid ◽

Site Characterization ◽

Fermentation Medium ◽

Production Optimization ◽

Main Body ◽

Crucial Step ◽

Drug Delivery Application ◽

Made In

Abstract Background Poly-γ-glutamic acid (γ-PGA) is a biopolymer of microbial origin, consisting of repeating units of l-glutamic acid and/or D-glutamic acid. The biopolymer has found use in the fields of agriculture, food, wastewater, and medicine, owing to its non-toxic, biodegradable, and biocompatible properties. Due to its biodegradability, γ-PGA is being tipped to dislodge synthetic plastics in drug delivery application. High cost of production, relative to plastics, is however a clog in the wheel of achieving this. Main body of abstract This review looked at the production, nanoparticles fabrication, and drug delivery application of γ-PGA. γ-PGA production optimization by modifying the fermentation medium to tailor towards the production of desirable polymer at reduced cost and techniques for the formulation of γ-PGA nanoparticle as well as its characterization were discussed. This review also evaluated the application of γ-PGA and its nanoparticles in the delivery of drugs to action site. Characterization of γ-PGA and its nanoparticles is a crucial step towards determining the applicability of the biopolymer. γ-PGA has been used in the delivery of active agents to action sites. Conclusion This review highlights some of the efforts that have been made in the appraisal of γ-PGA and its nanoparticles for drug delivery. γ-PGA is a candidate for future extensive use in drug delivery.

Download Full-text