Accelerated Transformation of Brushite Cement into Carbonate Apatite in Biomimetic Solution

2019 ◽  
Vol 800 ◽  
pp. 70-74
Author(s):  
Sahin Altundal ◽  
Marco Laurenti ◽  
Enrique Jose López‐Cabarcos ◽  
Jorge Rubio-Retama ◽  
Karlis Agris Gross
Keyword(s):  
Simulated Body Fluid ◽  
Blood Plasma ◽  
Human Blood ◽  
Body Fluid ◽  
High Reactivity ◽  
Human Blood Plasma ◽  
Carbonate Apatite ◽  
Optimal Composition ◽  
Low Crystalline

Brushite cement has advantages such as fast setting, high reactivity and good injectability over apatitic cements. To induce the bioactivity of brushite cements, the goal was to convert it into a bone-like low crystalline carbonate apatite. To achieve this induced transformation, potassium and magnesium were used as dopants which were claimed to be effective in the literature. The cements were immersed for 2 periods of time: 1 day and 6 weeks in Tas-Simulated-Body-Fluid (Tas-SBF) due to its excellent biomimetic properties with its adjusted HCO3- and Cl- ionic rates according to human-blood-plasma. 5% of potassium (to calcium sites) seemed to be more effective over magnesium modification. The aim of this study is to define an optimal composition in terms of transforming brushite into apatite.

Bioactivity of a Poly(70lactic-co-30glycolic acid)/15CaO-85SiO2 Composite with a Dual Pore Structure

2014 ◽  
Vol 614 ◽  
pp. 7-10
Author(s):  
Hye Young Shin ◽  
Sang Hee Shin ◽  
Sang Hoon Rhee
Keyword(s):  
Carbon Dioxide ◽  
Simulated Body Fluid ◽  
Pore Structure ◽  
Body Fluid ◽  
Sol Gel ◽  
Calcium Nitrate ◽  
Calcium Nitrate Tetrahydrate ◽  
Carbonate Apatite ◽  
Carbon Dioxide Gas ◽  
Low Crystalline

The low crystalline hydroxyl carbonate apatite forming capacity of a poly (70lactic-co-30glycolic acid)/15CaO-85SiO2 composite, which had a dual pore structure, was newly examined in simulated body fluid. The bioactive 15CaO-85SiO2 particles were synthesized by a sol-gel method using tetraethyl orthosilicate (TEOS) and calcium nitrate tetrahydrate under acidic condition followed by the heat treatment at 600°C for 3h. The poly (70lactic-co-30glycolic acid)/15CaO-85SiO2 composite was then prepared by a solvent casting using dimethylformide as a solvent. The composite was loaded into a high pressure chamber and then carbon dioxide gas was introduced achieving a final pressure of 20 MPa. After 3 days, carbon dioxide gas was released quickly and resultantly the dual pore structure was obtained. The samples were observed by FE-SEM and its bioactivity was tested in simulated body fluid.

Bioactivity of a Poly(70lactic-co-30glycolic acid)/15CaO-85SiO2 Composite with a Dual Pore Structure

2013 ◽  
Vol 587 ◽  
pp. 211-214
Author(s):  
Hye Young Shin ◽  
Sang Hee Shin ◽  
Sang Hoon Rhee
Keyword(s):  
Carbon Dioxide ◽  
Simulated Body Fluid ◽  
Pore Structure ◽  
Body Fluid ◽  
Sol Gel ◽  
Calcium Nitrate ◽  
Calcium Nitrate Tetrahydrate ◽  
Carbonate Apatite ◽  
Carbon Dioxide Gas ◽  
Low Crystalline

The low crystalline hydroxyl carbonate apatite forming capacity of a poly (70lactic-co-30glycolic acid)/15CaO-85SiO2 composite, which had a dual pore structure, was newly examined in simulated body fluid. The bioactive 15CaO-85SiO2 particles were synthesized by a sol-gel method using tetraethyl orthosilicate (TEOS) and calcium nitrate tetrahydrate under acidic condition followed by the heat treatment at 600°C for 3h. The poly (70lactic-co-30glycolic acid)/15CaO-85SiO2 composite was then prepared by a solvent casting using dimethylformide as a solvent. The composite was loaded into a high pressure chamber and then carbon dioxide gas was introduced achieving a final pressure of 20 MPa. After 3 days, carbon dioxide gas was released quickly and resultantly the dual pore structure was obtained. The samples were observed by FE-SEM and its bioactivity was tested in simulated body fluid.

Bioactive behaviors of porous apatite- and wollastonite-containing glass-ceramic in two kinds of simulated body fluid

2003 ◽  
Vol 18 (2) ◽  
pp. 433-441 ◽  
Author(s):  
Yunlong Zhang ◽  
Mineo Mizuno ◽  
Masaaki Yanagisawa ◽  
Hiroaki Takadama
Keyword(s):  
Simulated Body Fluid ◽  
Human Blood ◽  
Porous Glass ◽  
Glass Ceramic ◽  
Body Fluid ◽  
Formation Rate ◽  
Human Blood Plasma ◽  
Apatite Formation ◽  
Testing Material ◽  
Ion Concentrations

Simulated body fluid (SBF) has been widely used for assessment of bioactivities of different materials. Those kinds of conventional SBF (C-SBF) have a higher Cl− concentration and a lower HCO3− concentration than those of human blood plasma. Therefore, a revised simulated body fluid (R-SBF), with ion concentrations including those of Cl− and HCO3− exactly equal to those of human plasma, was recently developed. Porous glass-ceramic was used as the testing material to evaluate the two kinds of SBF. Results showed that C-SBF is considered more active than R-SBF because the porous glass-ceramic had a higher apatite formation rate on its surface,while R-SBF is considered to simulate the human body fluid more precisely than C-SBF.

Dual Layer Mixed Matrix Hollow Fiber Membranes for Outside-In Filtration of Human Blood Plasma

2020 ◽  
Author(s):  
O.E.M. ter Beek ◽  
M.K. van Gelder ◽  
C. Lokhorst ◽  
D.H.M. Hazenbrink ◽  
B.H. Lentferink ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Hollow Fiber ◽  
Human Blood Plasma ◽  
Hollow Fiber Membranes ◽  
Mixed Matrix ◽  
Fiber Membranes

scholarly journals Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma

2002 ◽  
Vol 43 (3) ◽  
pp. 365-374
Author(s):  
Elisa Campos ◽  
Leila Kotite ◽  
Patricia Blanche ◽  
Yasushi Mitsugi ◽  
Philip H. Frost ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Human Blood Plasma ◽  
Particle Fraction
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