Influence of Porous Microarchitecture on the In-Vitro Dissolution and Biological Behaviour of Porous Calcium Phosphate Ceramics

AbstractThe present work investigates surface biocompatibility of silicon-substituted calcium phosphate ceramics. Different silicon-substituted calcium phosphate ceramic bodies were prepared from co-precipitated powders by sintering at 1300°C. The in vitro bioactivity of the ceramics was assessed in simulated body fluid (SBF) at 37°C for periods up to 4 weeks. The changes in the surface morphology and composition were determined by scanning electron microscopy (SEM) coupled with electron probe microanalysis and energy dispersive spectrometer (EDX). Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to observe the change in ionic concentration of SBF after removal of the samples. The bioactivity of the ceramics increased with an increasing silicate ion substitution in a systematic way. The surface of ceramics with 2.23% silicon substitution was partially covered with apatite layer after one week, while ceramics with 8.1% silicon substitution were completely covered with apatite in the first week. The porous microstructure of high-concentration Si-substituted ceramics helps the dissolution of surface ions and the leaching process. This allows SBF to reach supersaturation in a short time and accelerate the deposition of apatite layer.

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In-Vitro Dissolution Characteristics of Calcium Phosphate/Calcium Sulphate Based Hybrid Biomaterials

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.254-256.585 ◽

2003 ◽

Vol 254-256 ◽

pp. 585-588

Author(s):

C.P. Cleere ◽

G.M. Insley ◽

M.E. Murphy ◽

P.N. Maher ◽

A.M. Murphy

Keyword(s):

Calcium Phosphate ◽

Calcium Sulphate ◽

In Vitro Dissolution ◽

Hybrid Biomaterials

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In Vitro Dissolution Behavior of Biphasic Tricalcium Phosphate Composite Powders Composed of α-Tricalcium Phosphate and β-Tricalcium Phosphate

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.368-372.1206 ◽

2008 ◽

Vol 368-372 ◽

pp. 1206-1208 ◽

Cited By ~ 11

Author(s):

Yan Bao Li ◽

Dong Xu Li ◽

Wen Jian Weng

Keyword(s):

Heat Treatment ◽

Calcium Phosphate ◽

Tricalcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Ph Value ◽

In Vitro Dissolution ◽

Dissolution Behavior ◽

Buffer Solution ◽

Composite Powders

Biphasic tricalcium phosphate (BTCP) powders composed of α-tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP) were prepared using amorphous calcium phosphate (ACP) precursor after heat treatment at 800oC. The in vitro dissolution behavior of the powders was examined after soaked in 0.1M NaAc-HAc buffer solution for different times. It was revealed that the Ca2+ and PO4 3- concentration, and pH value of the BTCP-soaked solution are higher than those of the α-TCP- and β-TCP-soaked solutions. The dissolution behavior of BTCP powders was explained. The specific dissolution behavior of BTCP powders can widen the biodegradation range of calcium phosphate family.

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In Vitro Bone Formation by Human Marrow Cell Culture on the Surface of Zinc-Releasing Calcium Phosphate Ceramics

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.192-195.503 ◽

2000 ◽

Vol 192-195 ◽

pp. 503-506 ◽

Cited By ~ 1

Author(s):

M. Ikeuchi ◽

Y. Dohi ◽

Hajime Ohgushi ◽

Toshiaki Noshi ◽

Katsuhiro Horiuchi ◽

...

Keyword(s):

Cell Culture ◽

Calcium Phosphate ◽

Bone Formation ◽

Marrow Cell ◽

Calcium Phosphate Ceramics

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Development and Evaluation of Sustained Release Matrix Tablets of Tramadol Hydrochloride

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2016.9.4.6 ◽

1970 ◽

Vol 9 (4) ◽

pp. 3364-3371

Author(s):

Ganesh Basarkar ◽

Vijay Suryawanshi ◽

Dinesh Hire

Keyword(s):

Calcium Phosphate ◽

Drug Release ◽

Sustained Release ◽

Water Soluble ◽

In Vitro Dissolution ◽

Release Mechanism ◽

Matrix System ◽

Tramadol Hydrochloride ◽

Sustained Release Formulation

The objective of the present study was to control the release of freely water soluble Tramadol hydrochloride over a prolonged period of time by embedding the drug into novel wax matrix system. The matrix granules were prepared by melt granulation technique. The need for the administration two to four times a day when larger dose are required can decrease patient compliance. Sustained release formulation that would maintain plasma levels for 24 hrs for once daily dosing of Tramadol hydrochloride was prepared. The compatibility of the drug and wax examined using Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectrophotometer (FTIR). The effect of wax concentration (5 to 35%) and channeling agents (Avicel PH-101 and Di-calcium phosphate) on the in vitro drug release at 24 hrs. was studied. Results of DSC confirmed drug-wax compatibility. Increasing the wax concentration resulted in a significant retardation of drug release. The drug release study revealed that the optimized formulation (F6) 30% novel wax sustained drug release for 24hrs. At the same wax concentration, drug release from tablets decreased with Di-calcium phosphate and increased with Avicel PH 101. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport. A hydrophobic matrix system is thus useful technique for prolonging the drug release of freely water soluble drugs such as Tramadol hydrochloride

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