The Clinical Implication of MAGE Gene Detection in Bronchial Washing Fluid in Routine Practice

This study aims to determine the gastric distribution, density, and diversity of Helicobacter pylori infection. Subtotal resection of the stomachs of three H. pylori-infected and asymptomatic obese patients were collected after a sleeve gastrectomy. Distribution and density of H. pylori were determined using culture and RT-PCR on multiple gastric sites (88, 176, and 101 biopsies per patient). Diversity of H. pylori strains was studied using antibiotic susceptibility testing, random amplified polymorphism DNA (RAPD) typing and cagA gene detection on single-colony isolates (44, 96, and 49 isolates per patient). H. pylori was detected in nearly all analyzed sites (354/365 biopsies, 97%). Antral density was higher in one patient only. The three stomachs were almost exclusively infected by an antibiotic-susceptible strain. One clarithromycin-resistant isolate in one biopsy was detected in two stomachs (1/44 and 1/49 isolates), while in the third one, eight (8/96 isolates) metronidazole-resistant isolates were detected. DNA typing showed infection with cagA-negative strains for one patient, cagA-positive strains for a second patient and the third patient was infected with two different strains of distinct cagA genotypes. Infection with H. pylori is shown to spread to the whole surface of the stomach, but a possibility of minor sub-population of antibiotic-resistant clones, undetectable in routine practice.

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UHV-TEM studies of laser-induced damage

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100087471 ◽

1991 ◽

Vol 49 ◽

pp. 632-633

Author(s):

T.S. Savage ◽

R. Ai ◽

D. Dunn ◽

L.D. Marks

Keyword(s):

Surface Science ◽

Rapid Heating ◽

Local Heating ◽

Routine Practice ◽

Transmission Electron ◽

Northwestern University ◽

Laser Induced Damage ◽

Set Up ◽

Focusing Lens ◽

Diffusion Of Impurities

The use of lasers for surface annealing, heating and/or damage has become a routine practice in the study of materials. Lasers have been closely looked at as an annealing technique for silicon and other semiconductors. They allow for local heating from a beam which can be focused and tuned to different wavelengths for specific tasks. Pulsed dye lasers allow for short, quick bursts which can allow the sample to be rapidly heated and quenched. This short, rapid heating period may be important for cases where diffusion of impurities or dopants may not be desirable.At Northwestern University, a Candela SLL - 250 pulsed dye laser, with a maximum power of 1 Joule/pulse over 350 - 400 nanoseconds, has been set up in conjunction with a Hitachi UHV-H9000 transmission electron microscope. The laser beam is introduced into the surface science chamber through a series of mirrors, a focusing lens and a six inch quartz window.

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I1307K APC gene variant has no clinical implication in Israeli jews at average or high risk for colorectal neoplasia

Gastroenterology ◽

10.1016/s0016-5085(01)80592-8 ◽

2001 ◽

Vol 120 (5) ◽

pp. A120-A121

Author(s):

H STRUL ◽

E BIRENBAUM ◽

B STERN ◽

D KAZANOV ◽

L THEODOR ◽

...

Keyword(s):

High Risk ◽

Clinical Implication ◽

Colorectal Neoplasia ◽

Apc Gene ◽

Gene Variant

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437 Ventricular tachycardia induction test immediately after positive pilsicainide provocation test in patients with Brugada syndrome; the clinical implication

EP Europace ◽

10.1016/s1099-5129(05)80289-2 ◽

2005 ◽

Vol 7 ◽

pp. 97-98

Keyword(s):

Ventricular Tachycardia ◽

Brugada Syndrome ◽

Clinical Implication ◽

Provocation Test

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Tailored interventions to support the implementation of the German national guideline on screening, diagnosis and treatment of alcohol-related disorders: a project protocol

SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice ◽

10.1024/0939-5911/a000629 ◽

2019 ◽

Vol 65 (6) ◽

pp. 373-381 ◽

Cited By ~ 2

Author(s):

Bernd Schulte ◽

Christina Lindemann ◽

Angela Buchholz ◽

Anke Rosahl ◽

Martin Härter ◽

...

Keyword(s):

Alcohol Use ◽

Guideline Implementation ◽

Implementation Strategies ◽

Organizational Factors ◽

Diagnosis And Treatment ◽

Primary Data ◽

Routine Practice ◽

Evidence Based ◽

Advisory Boards ◽

Prevention And Treatment

Abstract. Background: The German Guideline on Screening, Diagnosis and Treatment of Alcohol Use Disorders aims to increase the uptake of evidence-based interventions for the early identification, diagnosis, prevention and treatment of alcohol-related disorders in relevant healthcare settings. To date, dissemination has not been accompanied by a guideline implementation strategy. The aim of this study is to develop tailored guideline implementation strategies and to field-test these in relevant medical and psycho-social settings in the city of Bremen, Germany. Methods: The study will conduct an impact and needs assessment of healthcare provision for alcohol use orders in Bremen, drawing on a range of secondary and primary data to: evaluate existing healthcare services; model the potential impact of improved care on public health outcomes; and identify potential barriers and facilitators to implementing evidence-based guidelines. Community advisory boards will be established for the selection of single-component or multi-faceted guideline implementation strategies. The tailoring approach considers guideline, provider and organizational factors shaping implementation. In field tests quality outcome indicators of the delivery of evidence-based interventions will be evaluated accompanied by a process evaluation to examine patient, provider and organizational factors. Outlook: This project will support the translation of guideline recommendations for the identification, prevention and treatment of AUD in routine practice and therefore contributes to the reduction of alcohol-related burden in Germany. The project is running since October 2017 and will provide its main outcomes by end of 2020. Project results will be published in scientific journals and presented at national and international conferences.

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Decision letter for "Rare lymphomas in routine practice—Treatment and outcome in Waldenström's macroglobulinaemia in the prospective German Tumour Registry Lymphatic Neoplasms"

10.1002/hon.2740/v2/decision1 ◽

2020 ◽

Keyword(s):

Routine Practice ◽

Waldenstrom’S Macroglobulinaemia

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Postmarketing Surveillance Based on Electronic Patient Records: The IPCI Project

Methods of Information in Medicine ◽

10.1055/s-0038-1634402 ◽

1999 ◽

Vol 38 (04/05) ◽

pp. 339-344 ◽

Cited By ~ 88

Author(s):

J. van der Lei ◽

B. M. Th. Mosseveld ◽

M. A. M. van Wijk ◽

P. D. van der Linden ◽

M. C. J. M. Sturkenboom ◽

...

Keyword(s):

General Practitioner ◽

General Practitioners ◽

Validation Studies ◽

Resource Planning ◽

Routine Practice ◽

Patient Records ◽

Postmarketing Surveillance ◽

Electronic Patient Records ◽

Use Of Data ◽

Data Requirements

AbstractResearchers claim that data in electronic patient records can be used for a variety of purposes including individual patient care, management, and resource planning for scientific research. Our objective in the project Integrated Primary Care Information (IPCI) was to assess whether the electronic patient records of Dutch general practitioners contain sufficient data to perform studies in the area of postmarketing surveillance studies. We determined the data requirements for postmarketing surveil-lance studies, implemented additional software in the electronic patient records of the general practitioner, developed an organization to monitor the use of data, and performed validation studies to test the quality of the data. Analysis of the data requirements showed that additional software had to be installed to collect data that is not recorded in routine practice. To avoid having to obtain informed consent from each enrolled patient, we developed IPCI as a semianonymous system: both patients and participating general practitioners are anonymous for the researchers. Under specific circumstances, the researcher can contact indirectly (through a trusted third party) the physician that made the data available. Only the treating general practitioner is able to decode the identity of his patients. A Board of Supervisors predominantly consisting of participating general practitioners monitors the use of data. Validation studies show the data can be used for postmarketing surveillance. With additional software to collect data not normally recorded in routine practice, data from electronic patient record of general practitioners can be used for postmarketing surveillance.

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