scholarly journals IL-9 Promotes Th17 Cell Migration into the Central Nervous System via CC Chemokine Ligand-20 Produced by Astrocytes

2011 ◽  
Vol 186 (7) ◽  
pp. 4415-4421 ◽  
Author(s):  
Yan Zhou ◽  
Yoshifumi Sonobe ◽  
Tomohiko Akahori ◽  
Shijie Jin ◽  
Jun Kawanokuchi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Migration ◽  
Th17 Cell ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
The Central Nervous System ◽  
Cc Chemokine Ligand 20

Chemotropic Molecules: Guides for Axonal Pathfinding and Cell Migration During CNS Development

Physiology ◽  
2003 ◽  
Vol 18 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Fernando de Castro
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Migration ◽  
Complex Pattern ◽  
Axonal Pathfinding ◽  
Cns Development ◽  
The Central Nervous System

Different molecules (netrins, semaphorins, slits) with chemotropic functions and their receptors (neogenin, DCC, neuropilins, plexins, robos) have been identified that guide axons during development of the nervous system to establish the complex pattern of connections among a large number of neurons. These molecules have been recently identified to play a role in cell migration of the central nervous system during development.

scholarly journals CX3CL1/CX3CR1 in Alzheimer’s Disease: A Target for Neuroprotection

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Peiqing Chen ◽  
Wenjuan Zhao ◽  
Yanjie Guo ◽  
Juan Xu ◽  
Ming Yin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Central Nervous System ◽  
Nervous System ◽  
Early Diagnosis ◽  
Vital Role ◽  
Therapeutic Interventions ◽  
Chemokine Ligand ◽  
The Central Nervous System ◽  
Receptor Cx3cr1

CX3C chemokine ligand 1 (CX3CL1) is an intriguing chemokine belonging to the CX3C family. CX3CL1 is secreted by neurons and plays an important role in modulating glial activation in the central nervous system after binding to its sole receptor CX3CR1 which mainly is expressed on microglia. Emerging data highlights the beneficial potential of CX3CL1-CX3CR1 in the pathogenesis of Alzheimer’s disease (AD), a common progressive neurodegenerative disease, and in the progression of which neuroinflammation plays a vital role. Even so, the importance of CX3CL1/CX3CR1 in AD is still controversial and needs further clarification. In this review, we make an attempt to present a concise map of CX3CL1-CX3CR1 associated with AD to find biomarkers for early diagnosis or therapeutic interventions.

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