scholarly journals Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus

2020 ◽  
Vol 204 (5) ◽  
pp. 1091-1100 ◽  
Author(s):  
Jing Zhu ◽  
Alayna N. Hay ◽  
Ashley A. Potter ◽  
Madison W. Richwine ◽  
Thomas Sproule ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Renal Pathology ◽  
Systemic Lupus ◽  
Bxsb Mouse

scholarly journals Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

Hypertension ◽  
2010 ◽  
Vol 56 (4) ◽  
pp. 643-649 ◽  
Author(s):  
Marcia Venegas-Pont ◽  
Michaele B. Manigrasso ◽  
Samira C. Grifoni ◽  
Babbette B. LaMarca ◽  
Christine Maric ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Blood Pressure ◽  
Tumor Necrosis Factor ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Systemic Lupus ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals 6 Efficacy of cenerimod, a selective S1P1 receptor modulator, in the MRL/lpr mouse model of systemic lupus erythematosus

2019 ◽  
Author(s):  
Marianne M Martinic ◽  
Sylvie Froidevaux ◽  
Estelle Gerossier-Creusat ◽  
Enrico Vezzali ◽  
Anna Stalder ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
S1p1 Receptor ◽  
Receptor Modulator

scholarly journals Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

2012 ◽  
Vol 9 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Samuel K Shimp ◽  
Cristen B Chafin ◽  
Nicole L Regna ◽  
Sarah E Hammond ◽  
Molly A Read ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Mouse Model ◽  
Heat Shock Protein ◽  
Lupus Erythematosus ◽  
Heat Shock Protein 90 ◽  
Systemic Lupus

scholarly journals FcγRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus

Blood ◽  
2020 ◽  
Vol 136 (25) ◽  
pp. 2933-2945
Author(s):  
Imene Melki ◽  
Isabelle Allaeys ◽  
Nicolas Tessandier ◽  
Benoit Mailhot ◽  
Nathalie Cloutier ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mouse Model ◽  
Platelet Activation ◽  
Lupus Erythematosus ◽  
Bone Marrow Cells ◽  
Human Platelets ◽  
Interferon Response ◽  
Type I ◽  
Systemic Lupus ◽  
Autoimmune Inflammatory Disease

Abstract Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease characterized by deposits of immune complexes (ICs) in organs and tissues. The expression of FcγRIIA by human platelets, which is their unique receptor for immunoglobulin G antibodies, positions them to ideally respond to circulating ICs. Whereas chronic platelet activation and thrombosis are well-recognized features of human SLE, the exact mechanisms underlying platelet activation in SLE remain unknown. Here, we evaluated the involvement of FcγRIIA in the course of SLE and platelet activation. In patients with SLE, levels of ICs are associated with platelet activation. Because FcγRIIA is absent in mice, and murine platelets do not respond to ICs in any existing mouse model of SLE, we introduced the FcγRIIA (FCGR2A) transgene into the NZB/NZWF1 mouse model of SLE. In mice, FcγRIIA expression by bone marrow cells severely aggravated lupus nephritis and accelerated death. Lupus onset initiated major changes to the platelet transcriptome, both in FcγRIIA-expressing and nonexpressing mice, but enrichment for type I interferon response gene changes was specifically observed in the FcγRIIA mice. Moreover, circulating platelets were degranulated and were found to interact with neutrophils in FcγRIIA-expressing lupus mice. FcγRIIA expression in lupus mice also led to thrombosis in lungs and kidneys. The model recapitulates hallmarks of human SLE and can be used to identify contributions of different cellular lineages in the manifestations of SLE. The study further reveals a role for FcγRIIA in nephritis and in platelet activation in SLE.

scholarly journals A Novel Susceptibility Locus On Chromosome 2 in the (New Zealand Black × New Zealand White)F1 Hybrid Mouse Model of Systemic Lupus Erythematosus

2002 ◽  
Vol 168 (6) ◽  
pp. 3042-3049 ◽  
Author(s):  
Ziaur SM. Rahman ◽  
Soe-Kyaw Tin ◽  
Pia-Nina L. Buenaventura ◽  
Chiu-Han Ho ◽  
Eric P. H. Yap ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
New Zealand ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Susceptibility Locus ◽  
Chromosome 2 ◽  
Systemic Lupus ◽  
F1 Hybrid ◽  
Hybrid Mouse

Anti‐CXCL13 and anti‐TNF α combination therapy in a mouse model of systemic lupus erythematosus

2008 ◽  
Vol 22 (S2) ◽  
pp. 473-473
Author(s):  
Debra Bryce Gardner ◽  
Ashlyn Bassiri ◽  
Peter Bugelski ◽  
Robert Sarisky ◽  
Bailin Liang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Combination Therapy ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Tnf Α
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