scholarly journals Grape seed extract proanthocyanidins downregulate HIV- 1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells

2002 ◽  
Vol 35 (3-4) ◽  
Author(s):  
MADHAVAN P NAIR ◽  
CHITHAN KANDASWAMI ◽  
SUPRIYA MAHAJAN ◽  
HARIKRISHNA N NAIR ◽  
RAM CHAWDA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mononuclear Cells ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Ccr5 Gene ◽  
Peripheral Blood Mononuclear ◽  
Normal Peripheral Blood ◽  
Blood Mononuclear Cells ◽  
Hiv 1

scholarly journals Grape Seed Extract Activates Th1 Cells In Vitro

2002 ◽  
Vol 9 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Narayanan Nair ◽  
Supriya Mahajan ◽  
Ram Chawda ◽  
Chithan Kandaswami ◽  
Thomas C. Shanahan ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Mononuclear Cells ◽  
Biological Activities ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Antitumor Effects ◽  
Peripheral Blood Mononuclear ◽  
Diverse Range ◽  
Ifn Γ

ABSTRACT Although flavonoids manifest a diverse range of biological activities, including antitumor and antiviral effects, the molecular mechanisms underlying these activities await elucidation. We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-γ) by peripheral blood mononuclear cells) from healthy donors. Our results show that GSE significantly induced the transcription of IFN-γ mRNA as demonstrated by reverse transcription-PCR but had no effect on the Th2-derived cytokine interleukin-6. The enhancing effect of GSE on IFN-γ expression was further supported by a concomitant increase in the number of cells with intracytoplasmic IFN-γ as well as the synthesis and secretion of IFN-γ. Our results demonstrate that the potentially beneficial immunostimulatory effects of GSE may be mediated through the induction of IFN-γ.

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