scholarly journals Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Massimo Iafrate ◽  
Mariangela Mancini ◽  
Tommaso Prayer Galetti ◽  
Serena Szekely ◽  
Edoardo Zattra ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Precancerous Lesions ◽  
Treatment Modalities ◽  
Imiquimod Cream ◽  
Skin Cancers ◽  
Frequent Relapses ◽  
Erythroplasia Of Queyrat ◽  
Non Surgical Treatment

Erythroplasia of Queyrat (EQ) is an intraepidermal carcinoma in situ presenting clinically as a sharply demarcated, slightly raised erythematosus plaque on the glans penis or the inner side of the foreskin. Various treatment modalities for EQ have been proposed, including electrocautery and curettage, topical 5-floururacil cream, imiquimod cream, isotretinoin, cryotherapy, laser therapy, radiotherapy, ingenol mebutate gel and photodynamic therapy (PDT). Most of these treatments are limited by low clearance rates and frequent relapses. Surgical treatment including local excision, Mohs micrographic surgery and partial or total penectomy, ensures adequate healing rates. However, discomfort consequent to surgical treatment might be unacceptable. Topical PDT using the methyl ester of 5-aminolaevulinic acid (MAL) is an established non-surgical treatment of cutaneous precancerous lesions and skin cancers. We present the case of a 60-year-old uncircumcised man affected by EQ of the penis successfully treated with MAL-PDT, performed five times, two weeks apart, with no recurrences after 6 years.

Study of photodynamic therapy in skin cancers and precancerous lesions

1993 ◽  
Author(s):  
Jiabi Wang ◽  
Menglin Gao ◽  
Shijun Wen ◽  
Mianjing Wang
Keyword(s):  
Photodynamic Therapy ◽  
Precancerous Lesions ◽  
Skin Cancers

Photodynamic therapy with M-ALA as non surgical treatment option in patients with primary extramammary Paget's disease

2013 ◽  
Vol 130 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Rosanna Fontanelli ◽  
Andrea Papadia ◽  
Fabio Martinelli ◽  
Domenica Lorusso ◽  
Barbara Grijuela ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Treatment Option ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Non Surgical Treatment ◽  
Extramammary Paget's Disease

scholarly journals Analysis of clinical and microbiological results of photodynamic therapy as support in non-surgical treatment of periodontitis – preliminary study

2019 ◽  
pp. 35-41
Author(s):  
Adrian Maj ◽  
Aida Kusiak ◽  
Katarzyna Garbacz ◽  
Marta Ziółkowska-Klinkosz
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Periodontal Disease ◽  
Periodontal Treatment ◽  
Periodontal Pocket ◽  
Therapeutic Effects ◽  
Before And After ◽  
Microbiological Laboratory ◽  
Pre Treatment ◽  
Non Surgical Treatment

Introduction. Photodynamic therapy is supportive method of non-surgical treatment of periodontitis. The aim of the study was the assessment of photodynamic therapy impact on periodontal disease clinical parameters with a particular emphasis on microbiological aspects during periodontal treatment. Material and methods. The research was conducted on seven healthy patients aged 26- 55 years. All the patients were treated with a non-surgical (SRP) periodontal treatment. Then, the assisted photodynamic therapy was applied in selected pockets. Samples of the material obtained from periodontal pockets before and after the treatment were cultured in a microbiological laboratory. Results. After the introduced therapy the clinical improvement of periodontal disease was observed in the majority (6/7) of patients taking part in the study. There obtained the elimination of inflammation to 85.7% of the patients. Periodontal pocket depths have deteriorated from 0.5 to 3.0 mm in comparison to the pre-treatment values. The overall number of bacteria compared to the pre-treatment value was reduced. In addition, there was noticed a decrease in the number of periopathogens. Control samples showed a vivid dominance of the physiological flora. Conclusions. The non-surgical treatment of periodontitis in combination with the supportive action of photodynamic therapy has promising therapeutic effects by reducing the inflammation and decreasing the depth of periodontal pockets. The change in the ratio of periopathogens to physiological flora may indicate the restoration and maintenance of the state balance in periodontal pockets for patients with periodontitis.

scholarly journals Evidence-based treatment of osteoporotic vertebral compression fracture

2021 ◽  
Vol 64 (3) ◽  
pp. 200-207
Author(s):  
Subum Lee ◽  
Dae-Chul Cho ◽  
Kyong-Tae Kim ◽  
Young-Seok Lee
Keyword(s):  
Surgical Treatment ◽  
Outcome Measurement ◽  
Treatment Guideline ◽  
Treatment Modalities ◽  
Vertebral Compression Fractures ◽  
Controlled Trials ◽  
Evidence Based ◽  
Evidence Based Treatment ◽  
Significant Difference ◽  
Non Surgical Treatment

The prevalence and medical costs of osteoporotic vertebral compression fractures (OVCFs) are on the rise. However, a concrete evidence-based treatment guideline has not yet been established. Despite that numerous randomized controlled trials (RCTs) were performed, the study design and outcome measurement were heterogeneous, and the results were not unified. The purpose of this review is to compare the results of high level-evidence studies to provide a background for evidence-based OVCF treatment. Many reports showed that vertebroplasty has better clinical outcomes than non-surgical treatment for OVCF, but the results of three double-blinded RCTs with the highest level of evidence did not show a significant difference between vertebroplasty and sham procedure. Whether undergoing surgical or non-surgical treatment, OVCF patient management should be started by managing osteoporosis first. Meanwhile, in the results of RCTs related to the comparison of conservative treatment modalities, the benefit of braces and a specific analgesic prescription protocol was also unclear. The presented results of each clinical trial were generally inconsistent and may not be appropriate in all situations. Any decision by clinicians to apply this evidence must be made considering individual patients and available resources. At present, controversy remains about the best treatment modality for OVCF. Large, multicenter, placebo/sham-controlled trials are needed to address this gap and establish strong evidence-based guidelines.

scholarly journals Surgical and non-surgical treatment modalities for glomuvenous malformations

2021 ◽  
Vol 27 (7) ◽  
Author(s):  
Aatman Shah ◽  
Michael Tassavor ◽  
Sayesha Sharma ◽  
Bryan Tassavor ◽  
Richard Torbeck
Keyword(s):  
Surgical Treatment ◽  
Treatment Modalities ◽  
Non Surgical Treatment

Non-melanoma skin cancer and premalignant conditions

2021 ◽  
pp. 69-78
Author(s):  
Barbara Jemec ◽  
Gregor B.E. Jemec
Keyword(s):  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Carcinoma Squamous Cell ◽  
Non Surgical Treatment ◽  
Melanoma Skin

This chapter describes the diagnosis, non-surgical treatment, and surgical treatment of non-melanoma skin cancers, such as basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and others.

scholarly journals “Beating osteoARThritis”: Development of a stepped care strategy to optimize utilization and timing of non-surgical treatment modalities for patients with hip or knee osteoarthritis

2011 ◽  
Vol 30 (12) ◽  
pp. 1623-1629 ◽  
Author(s):  
Agnes J. Smink ◽  
Cornelia H. M. van den Ende ◽  
Thea P. M. Vliet Vlieland ◽  
Bart A. Swierstra ◽  
Joke H. Kortland ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Knee Osteoarthritis ◽  
Stepped Care ◽  
Treatment Modalities ◽  
Non Surgical Treatment
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