scholarly journals Surgical and non-surgical treatment modalities for glomuvenous malformations

2021 ◽  
Vol 27 (7) ◽  
Author(s):  
Aatman Shah ◽  
Michael Tassavor ◽  
Sayesha Sharma ◽  
Bryan Tassavor ◽  
Richard Torbeck
2021 ◽  
Vol 64 (3) ◽  
pp. 200-207
Author(s):  
Subum Lee ◽  
Dae-Chul Cho ◽  
Kyong-Tae Kim ◽  
Young-Seok Lee

The prevalence and medical costs of osteoporotic vertebral compression fractures (OVCFs) are on the rise. However, a concrete evidence-based treatment guideline has not yet been established. Despite that numerous randomized controlled trials (RCTs) were performed, the study design and outcome measurement were heterogeneous, and the results were not unified. The purpose of this review is to compare the results of high level-evidence studies to provide a background for evidence-based OVCF treatment. Many reports showed that vertebroplasty has better clinical outcomes than non-surgical treatment for OVCF, but the results of three double-blinded RCTs with the highest level of evidence did not show a significant difference between vertebroplasty and sham procedure. Whether undergoing surgical or non-surgical treatment, OVCF patient management should be started by managing osteoporosis first. Meanwhile, in the results of RCTs related to the comparison of conservative treatment modalities, the benefit of braces and a specific analgesic prescription protocol was also unclear. The presented results of each clinical trial were generally inconsistent and may not be appropriate in all situations. Any decision by clinicians to apply this evidence must be made considering individual patients and available resources. At present, controversy remains about the best treatment modality for OVCF. Large, multicenter, placebo/sham-controlled trials are needed to address this gap and establish strong evidence-based guidelines.


2011 ◽  
Vol 30 (12) ◽  
pp. 1623-1629 ◽  
Author(s):  
Agnes J. Smink ◽  
Cornelia H. M. van den Ende ◽  
Thea P. M. Vliet Vlieland ◽  
Bart A. Swierstra ◽  
Joke H. Kortland ◽  
...  

2017 ◽  
Vol 102 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Ana Beatriz Diniz Grisolia ◽  
Ricardo Christopher Couso ◽  
Suzana Matayoshi ◽  
Raymond S Douglas ◽  
César Augusto Briceño

Thyroid eye disease (TED) is an autoimmune condition with an unpredictable course that may lead to permanent facial disfigurement. Eyelid retraction is one of the most common findings, and frequently demands attention due to ocular exposure and impaired cosmesis. Surgical treatment remains the most effective option, but there is a role for temporary corrections during the active phase of the disease, as well as in patients who are poor surgical candidates. The aim of this review is to describe the non-surgical modalities currently available for treatment of eyelid malposition in TED. The authors have focused on the use of hyaluronic acid, triamcinolone injections and botulinum toxin type A as non-surgical treatment alternatives, paying special attention to dosing, technique, efficacy and duration of effect. Non-surgical treatment modalities may represent viable in cases where surgical correction is not an option. Although temporary, these modalities appear to be beneficial for ocular exposure remediation, improving quality of life and broadening our therapeutic arsenal.


2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Massimo Iafrate ◽  
Mariangela Mancini ◽  
Tommaso Prayer Galetti ◽  
Serena Szekely ◽  
Edoardo Zattra ◽  
...  

Erythroplasia of Queyrat (EQ) is an intraepidermal carcinoma in situ presenting clinically as a sharply demarcated, slightly raised erythematosus plaque on the glans penis or the inner side of the foreskin. Various treatment modalities for EQ have been proposed, including electrocautery and curettage, topical 5-floururacil cream, imiquimod cream, isotretinoin, cryotherapy, laser therapy, radiotherapy, ingenol mebutate gel and photodynamic therapy (PDT). Most of these treatments are limited by low clearance rates and frequent relapses. Surgical treatment including local excision, Mohs micrographic surgery and partial or total penectomy, ensures adequate healing rates. However, discomfort consequent to surgical treatment might be unacceptable. Topical PDT using the methyl ester of 5-aminolaevulinic acid (MAL) is an established non-surgical treatment of cutaneous precancerous lesions and skin cancers. We present the case of a 60-year-old uncircumcised man affected by EQ of the penis successfully treated with MAL-PDT, performed five times, two weeks apart, with no recurrences after 6 years.


2020 ◽  
Vol 63 (12) ◽  
pp. 741-747
Author(s):  
Chong Won Choi

Vitiligo is an acquired depigmenting skin disorder that affects 0.5% to 2% of the population. Skin lesions from vitiligo, white macules and patches on the skin, can pose a substantial psychological burdencan, causing a significant decrease in one’s quality of life. Recent basic and clinical studies have found that vitiligo is an autoimmune disorder, mediated by CD8+ T-cell and interferon-γ-mediated cytokine/chemokines. Although no treatment modality presents a complete cure for vitiligo, current treatment modalities have a modest effect on vitiligo by reversing the disease’s progression, inducing its stabilization, and promoting melanocyte regeneration. Current non-surgical treatment modalities include topical corticosteroids, topical calcineurin inhibitors, systemic corticosteroids, and phototherapy such as narrowband ultraviolet B phototherapy and excimer laser. In addition, clinicians have used and combined non-surgical treatment modalities based on the activity and extent of vitiligo. Moreover, considering the high risk of vitiligo relapse, maintenance therapy for re-pigmented lesions has also been introduced. Lastly, based on the results of recent translational research, new and emerging treatment modalities have been introduced, such as Janus kinase inhibitors. This review presents an overview of the current non-surgical treatment modalities for vitiligo and discusses emerging treatments.


2013 ◽  
Vol 01 (01) ◽  
pp. 055-057
Author(s):  
Amandeep Singh Uppal ◽  
Jagat Bhushan ◽  
Mandeep Kaur Bhullar ◽  
Gulsheen Kaur Kochhar

AbstractApexification is a method to induce a calcific barrier across an open apex of an immature, pulpless tooth. Apical closure occurs approximately three years after eruption. Traumatic injuries to young permanent teeth before root formation is complete commonly occur in children resulting in open apex. This can be treated by Surgical or Non - Surgical treatment modalities. Non surgical treatment modalities include various methods such as Customized cone, Short fill technique, Apexification with various materials and One visit apexification. Various materials that can be used for apexification include Calcium hydroxide, MTA, Tricalcium phosphate, Dentin chips, Calcium phosphate ceramics and hydroxyapatite and bone morphogenetic proteins. Calcium hydroxide is the most common and traditional material employed for inducing apexification. This is a multi visit technique requiring six months to four years to complete.


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