A case of primary mucosa-associated lymphoid tissue lymphoma of the prostate

We report a case of primary mucosa-associated lymphoid tissue (MALT) lymphoma of the prostate. A 67-year-old man presented with urinary obstruction and an elevated prostate-specific antigen (PSA) level. A physical examination revealed mild prostate enlargement and no lymphadenopathy. A needle biopsy and immunohistochemical studies of the prostate were performed, which revealed marginal zone B-cell MALT-type lymphoma. A bone marrow aspiration and biopsy did not show involvement by lymphoma. Magnetic resonance imaging (MRI) of the abdomen and the pelvis revealed no lymphadenopathy or ascites. There was no involvement of other sites by lymphoma. The patient was diagnosed and staged as extranodal marginal zone B-cell MALT-type lymphoma of the prostate, low grade and stage I. The patient received external beam radiation therapy to the prostate with a total dose of 3600cGy in 22 fractions, and became free of disease within the following 15 months.

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Primary CNS Extranodal Marginal Zone B-Cell Lymphoma: A Case Series of 2 Patients Treated with External Beam Radiation Therapy

Case Reports in Oncology ◽

10.1159/000515780 ◽

2021 ◽

pp. 725-732

Author(s):

Rojine Ariani ◽

Leslie Ballas

Keyword(s):

Radiation Therapy ◽

B Cell ◽

Marginal Zone ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

External Beam Radiation Therapy ◽

External Beam Radiation ◽

Low Grade ◽

External Beam ◽

Beam Radiation

Primary CNS extranodal marginal zone B-cell lymphoma (MZBL) is a rare low-grade non-Hodgkin lymphoma characterized predominantly by small B cells, plasma cells, monocytoid cells, and scattered large immunoblasts. As a slow-growing tumor that remains localized, primary CNS MZBL carries an excellent clinical prognosis. Here, we report two cases of primary CNS MZBL successfully treated using external beam radiation therapy along with a literature review.

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Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways

Blood ◽

10.1182/blood.v99.1.3 ◽

2002 ◽

Vol 99 (1) ◽

pp. 3-9 ◽

Cited By ~ 133

Author(s):

Petr Starostik ◽

Jochen Patzner ◽

Axel Greiner ◽

Stephan Schwarz ◽

Jörg Kalla ◽

...

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Gene Locus ◽

Marginal Zone ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Low Grade ◽

High Grade ◽

Clonal Proliferation ◽

Large B Cell Lymphoma

Low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type can transform into high-grade diffuse large B-cell lymphoma (DLBCL). Up to 60% of the MALT lymphomas contain the recently described t(11;18). However, this translocation has not been detected in any DLBCL so far. To elucidate the pathogenesis of these tumors, microsatellite screening of 24 gastric MALT lymphomas was performed and the results were compared with aberrations detected in a previous study on gastric DLBCL. The most frequent aberration, found in 21% of the MALT lymphomas that were exclusively t(11;18)-negative cases, was amplification of the 3q26.2-27 region (harboring the locus of the BCL6 gene). Allelic imbalances in regions 3q26.2-27, 6q23.3-25, 7q31, 11q23-24, and 18q21 were shared by both MALT lymphoma and DLBCL. Loss of heterozygosity in regions 5q21 (APC gene locus), 9p21 (INK4A/ARF), 13q14 (RB), and 17p13(p53) and allelic imbalances in 2p16, 6p23, and 12p12-13 occurred exclusively in DLBCL. Only one of 10 t(11;18)-positive MALT lymphomas showed an additional clonal abnormality. These tumors thus display features of a clonal proliferation characterized by the presence of the t(11;18). However, they only rarely display secondary aberrations and do not seem to transform into DLBCL. In contrast, t(11;18)-negative MALT lymphomas show numerous allelic imbalances—some of them identical with aberrations seen in DLBCL—suggesting that this group is the source of tumors eventually transforming into high-grade DLBCL.

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Marginal Zone Lymphoma (Low-grade B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Type) of Skin and Subcutaneous Tissue

The American Journal of Surgical Pathology ◽

10.1097/00000478-199608000-00010 ◽

1996 ◽

Vol 20 (8) ◽

pp. 1011-1023 ◽

Cited By ~ 121

Author(s):

Elizabeth M. Bailey ◽

Judith A. Ferry ◽

Nancy L. Harris ◽

Martin C. Mihm ◽

Joseph O. Jacobson ◽

...

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Marginal Zone ◽

Cell Lymphoma ◽

Subcutaneous Tissue ◽

B Cell Lymphoma ◽

Marginal Zone Lymphoma ◽

Tissue Type ◽

Low Grade

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Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue

Blood ◽

10.1182/blood.v85.8.2000.bloodjournal8582000 ◽

1995 ◽

Vol 85 (8) ◽

pp. 2000-2004 ◽

Cited By ~ 210

Author(s):

AC Wotherspoon ◽

TM Finn ◽

PG Isaacson

Keyword(s):

B Cell ◽

Malt Lymphoma ◽

Lymphoid Tissue ◽

Marginal Zone ◽

B Cell Lymphoma ◽

Low Grade ◽

B Cell Lymphomas ◽

Splenic Lymphoma ◽

Trisomy 3 ◽

Primary Splenic Lymphoma

Characteristic chromosomal aberrations have been associated with subtypes of non-Hodgkin's lymphoma with distinct clinicopathologic features. Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) form such a group and might be expected to be characterized by a specific cytogenetic abnormality. Metaphase analyses of MALT lymphoma are rare due to problems with fresh tissue collection and poor in vitro proliferation. However, the small number of published series suggests that chromosome trisomies, particularly trisomy 3, might be characteristic of these tumors. The application of interphase cytogenetic techniques to routinely processed material allows the examination of a large series of archival cases and is particularly useful for the demonstration of chromosome trisomies. We have used this technique to analyze 70 cases of low-grade MALT lymphoma from various sites and found trisomy 3 in 60%. This finding compares with 16% in low-grade nodal B-cell lymphoma and 27% in primary splenic lymphoma of marginal zone type (splenic lymphoma with villous lymphocytes). These results provide further evidence that low-grade MALT lymphomas from all sites form a single pathologic entity distinct from nodal B-cell lymphomas. Although MALT lymphoma and primary splenic lymphoma may arise from marginal zone B cells, they are genetically distinct.

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Somatic hypermutation in low-grade mucosa-associated lymphoid tissue- type B-cell lymphoma

Blood ◽

10.1182/blood.v86.9.3528.bloodjournal8693528 ◽

1995 ◽

Vol 86 (9) ◽

pp. 3528-3534 ◽

Cited By ~ 131

Author(s):

Y Qin ◽

A Greiner ◽

MJ Trunk ◽

B Schmausser ◽

MM Ott ◽

...

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Germ Line ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Tissue Type ◽

Low Grade ◽

Type B ◽

Nucleotide Substitutions ◽

Malt Type Lymphoma

The origin of low-grade mucosa-associated lymphoid tissue (MALT)-type B- cell lymphoma is still unclear. Using a novel two-step procedure, we have sequenced the Ig VH genes expressed by cells from four patients with gastric low-grade MALT-type lymphoma. The nucleotide sequences of the complementarity determining region 3 (CDR3) of the genomic DNA were first amplified using consensus oligonucleotide primers, then sequenced. Based on the CDR3 sequence amplified from each MALT lymphoma, individual tumor-specific primers were synthesized and used directly in the polymerase chain reaction (PCR) to analyze the sequences of their Ig heavy-chain variable region. When compared with the germ-line sequence, many nucleotide substitutions, mainly in the CDRs, were found in the variable gene sequences of the four MALT lymphomas. The mutations showed a high replacement-to-silent ratio and were distributed in a way which suggested that the tumor cells had been positively selected through their antigen receptor. Our findings indicate that the MALT-type lymphoma B cells are hypermutated postgerminal center lymphocytes that have undergone antigen selection.

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A case of primary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphoma treated by radiofrequency ablation (RFA), and a literature review

Journal of International Medical Research ◽

10.1177/0300060521999539 ◽

2021 ◽

Vol 49 (3) ◽

pp. 030006052199953

Author(s):

Zhe Xu ◽

Chong Pang ◽

Jidong Sui ◽

Zhenming Gao

Keyword(s):

Radiofrequency Ablation ◽

B Cell ◽

Malt Lymphoma ◽

Lymphoid Tissue ◽

Marginal Zone ◽

B Cell Lymphoma ◽

Liver Malignancy ◽

Characteristic Imaging ◽

Malt Type Lymphoma

Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare liver malignancy that usually lacks characteristic imaging findings and which is often misdiagnosed. We report a 63-year-old woman diagnosed with primary hepatic extranodal marginal zone B-cell lymphoma, MALT type. The patient underwent needle biopsy and radiofrequency ablation (RFA), and showed no signs of relapse during the 12-month postoperative follow-up. This case stresses the rarity of primary hepatic MALT-type lymphoma and the unique and effective treatment for this patient. Our patient received RFA, which showed good efficacy and which provides a new option for the treatment of hepatic MALT lymphoma. We also present our findings from a systematic review to improve the current understanding of this disease.

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Ocular marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue masquerading as chalazion: a case report

Malaysian Journal of Ophthalmology ◽

10.35119/myjo.v3i1.153 ◽

2021 ◽

Vol 3 (1) ◽

pp. 57-63

Author(s):

Nik Ahmad Mat Zaidan Syafiq ◽

Juana Wan Ab Kadir Azida ◽

Sagili Chandrasekhara Reddy ◽

Ismail Fazliana

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Marginal Zone ◽

Cell Lymphoma ◽

Correct Diagnosis ◽

Anterior Segment ◽

B Cell Lymphoma ◽

Lower Eyelid ◽

Low Grade ◽

The Right

A case of ocular marginal zone non-Hodgkin B-cell lymphoma of mucosa-associated lymphoid tissue of the conjunctiva masquerading as chalazion is reported in a 57-year-old Chinese man, known to have diabetes mellitus. He presented with painless swelling of the lower lid and redness in the right eye for 3 months duration. A diagnosis of chalazion was made, and incision and curettage were performed by a general ophthalmologist. The swelling worsened and spread to the whole lower lid. Magnetic resonance imaging showed a lesion involving the right periorbital region limited to the anterior orbital septum that was hypointense on T1 and hyperintense on T2. A diagnosis of periorbital cellulitis with possibility of lymphoma was suggested. When he came to our eye clinic for expert opinion, his visual acuity, anterior segment and fundus were normal except early cataract changes in both eyes. There was a hard, non-tender, immobile mass within the lower eyelid associated with conjunctival injection and chemosis. Histopathology of the conjunctival biopsy showed features of low-grade non-Hodgkin B-cell lymphoma and the immunohistochemistry report was suggestive of marginal zone lymphoma. He was treated with chemotherapy (cyclophosphamide, vincristine, prednisolone) and radiotherapy, following which the swelling resolved. When patients do not respond to treatment as expected after incision and curettage of chalazion, a high index of possibility of malignancy should be kept in mind whenever a recurrence of hard swelling is observed at the same site in the eyelid. All suspicious lesions should be biopsied to find out the correct diagnosis.

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True Histiocytic Lymphoma of the Stomach Associated with Low-grade B-cell Mucosa-associated Lymphoid Tissue (Malt)-type Lymphoma

The American Journal of Surgical Pathology ◽

10.1097/00000478-199611000-00013 ◽

1996 ◽

Vol 20 (11) ◽

pp. 1406-1411 ◽

Cited By ~ 30

Author(s):

T. Álvaro ◽

R. Bosch ◽

M. T. Salvadó ◽

M. A. Piris

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Low Grade ◽

Histiocytic Lymphoma ◽

Malt Type Lymphoma

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International multicentre retrospective cohort study of ocular adnexal marginal zone B-cell lymphoma

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314008 ◽

2019 ◽

Vol 104 (3) ◽

pp. 357-362 ◽

Cited By ~ 7

Author(s):

Tine Gadegaard Hindsø ◽

Bita Esmaeli ◽

Frederik Holm ◽

Lauge Hjorth Mikkelsen ◽

Peter Kristian Rasmussen ◽

...

Keyword(s):

Cohort Study ◽

B Cell ◽

Marginal Zone ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

External Beam Radiation ◽

Beam Radiation ◽

Term Survival ◽

Ann Arbor ◽

Disseminated Disease

Backgrounds/aimsTo date, this is the largest cohort study on extranodal marginal zone B-cell lymphoma (EMZL) of the ocular adnexa (OA). The aim of the study was to characterise the clinical features of OA-EMZL.MethodsA retrospective multicentre study involving seven international eye cancer centres. Data were collected from 1 January 1980 through 31 December 2017. A total of 689 patients with OA-EMZL were included.ResultsThe median follow-up time was 42 months. The median age was 62 years (range, 8–100 years), and 55 % (378/689 patients) of patients were women. The majority of patients (82%, 558/680 patients) were diagnosed with primary OA-EMZL with Ann Arbor stage IE (90%, 485/541 patients) and American Joint Committee on Cancer stage T2 (61%, 340/557 patients) at the time of diagnosis. The orbit (66%, 452/689 patients) and the conjunctiva (37%, 255/689 patients) were the most frequently involved anatomical structures. The 5-year, 10-year and 20-year disease-specific survival (DSS) were 96%, 91% and 90%, respectively. Stage IE patients treated with external beam radiation therapy (EBRT) as monotherapy (10-year DSS, 95%) were found to have a better DSS than stage IE patients treated with chemotherapy (10-year DSS, 86%). Stage IIIE/IVE patients treated with chemotherapy and rituximab had a better DSS (10-year DSS, 96%) than stage IIIE/IVE patients treated with chemotherapy without rituximab (10-year DSS, 63%).Conclusions and relevanceEMZL is a slow-growing tumour with an excellent long-term survival. Low-dose EBRT as monotherapy should be considered in localised OA-EMZL. Rituximab-based chemotherapy should be chosen in those patients with disseminated disease.

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