Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies

Background: Acute stress response to heart surgery can cause major morbidity in patients. The trace of selenium is useful for preventing heart damage. Although the trend of selenium changes is of high importance for body balance, the usefulness of routine use and effectiveness of this element for patients under open-heart surgery is still unclear. Objectives: This study aimed at assessing serum selenium level before and after open-heart surgery and the relationship between selenium trace and patient outcome. Methods: This prospective analytical study was performed on 100 patients undergoing open-heart surgery using cardiopulmonary bypass (CPB). In all patients, the serum level was measured at a predetermined time (before surgery and one and two days after surgery). Then, the relationship between serum selenium and patient outcome was assessed. Results: The mean serum selenium level in patients on admission was 72.90 ± 14.62 μg/L, one day after surgery was 71.20 ± 15.84 μg/L, and two days after surgery was 71.54 ± 15.97 μg/L. Serum selenium levels were inversely and significantly associated with age (r = -0.183; P = 0.034, 013) duration of surgery (r = -221 and P = 0.014), duration of intensive care unit stay (r = 0.204, P = 0.021), and duration of CPB (r = 0.223, P = 013). Conclusions: Based on this study’s results, a low level of selenium can affect patients’ outcomes after open-heart surgery.

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Faculty Opinions recommendation of Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735328044.793560074 ◽

2019 ◽

Author(s):

Anthony Harries ◽

Kudakwashe C Takarinda

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Observational Studies ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Tuberculosis Patients ◽

Sub Saharan ◽

Prevalence Of Diabetes Mellitus

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Serum Selenium Level and 10-Year Survival after Melanoma

Biomedicines ◽

10.3390/biomedicines9080991 ◽

2021 ◽

Vol 9 (8) ◽

pp. 991

Author(s):

Emilia Rogoża-Janiszewska ◽

Karolina Malińska ◽

Piotr Baszuk ◽

Wojciech Marciniak ◽

Róża Derkacz ◽

...

Keyword(s):

Selenium Level ◽

Serum Selenium ◽

Lower Survival Rate ◽

Treatment Regimens ◽

Melanoma Diagnosis ◽

Serum Selenium Levels ◽

Melanoma Prognosis ◽

Level I ◽

Low Selenium ◽

Serum Selenium Level

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.

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