scholarly journals Serum Selenium Level and 10-Year Survival after Melanoma

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 991
Author(s):  
Emilia Rogoża-Janiszewska ◽  
Karolina Malińska ◽  
Piotr Baszuk ◽  
Wojciech Marciniak ◽  
Róża Derkacz ◽  
...  
Keyword(s):  
Selenium Level ◽  
Serum Selenium ◽  
Lower Survival Rate ◽  
Treatment Regimens ◽  
Melanoma Diagnosis ◽  
Serum Selenium Levels ◽  
Melanoma Prognosis ◽  
Level I ◽  
Low Selenium ◽  
Serum Selenium Level

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.

Serum selenium and risk of prostate cancer in Japanese men

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16166-e16166
Author(s):  
M. Nozawa ◽  
M. Yoshida ◽  
Y. Saito ◽  
M. Nakagawa ◽  
T. Ozeki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Biopsy ◽  
Selenium Level ◽  
Control Group ◽  
Case Group ◽  
Serum Selenium ◽  
Inverse Association ◽  
Serum Selenium Levels ◽  
Low Selenium ◽  
Serum Selenium Level

e16166 Background: Epidemiologic studies suggest that low selenium levels are associated with an increased incidence of prostate cancer, although results are conflicting. We examined the association between serum selenium levels and risk of prostate cancer in men who received a prostate biopsy in our hospital. Methods: Our prospective study included 82 patients who received a prostate biopsy based on elevated PSA levels over 4.0ng/ml. Serum from each patient was sampled to determine the selenium level at the time of biopsy. Of these, 47 patients were diagnosed with prostate cancer (case group) and no malignant lesions in the biopsy specimen were detected in the remains, 35 patients (control group). Results: The mean serum selenium levels in the case and control group were 120.4 (SD, 14.4) ng/mL and 118.5 (SD, 16.1) ng/mL, respectively (p = 0.588). Serum selenium levels at biopsy were not associated with risk of prostate cancer diagnosis. In the case group, the mean serum selenium levels in patients diagnosed with 6 or less in Gleason score and 7 or more were 121.0 (SD, 9.9) ng/mL (n = 14) and 120.1 (SD, 16.1) ng/mL (n = 33), respectively (p = 0.851). Serum selenium levels at biopsy were not associated with Gleason score in the case group. An inverse association between serum selenium and PSA levels at biopsy was observed (p = 0.030). No correlation was observed between serum selenium level and age at biopsy. Conclusions: From this study, serum selenium level cannot predict the result of prostate biopsy. The inverse association between serum selenium and PSA levels may suggest that low selenium levels are associated with an increased incidence of prostate cancer. No significant financial relationships to disclose.

scholarly journals Association of Initial Low Serum Selenium Level with Infectious Complications and 30-Day Mortality in Multiple Trauma Patients

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1844 ◽  
Author(s):  
Soon Bo Choi ◽  
Yun Tae Jung ◽  
Jae Gil Lee
Keyword(s):  
Multiple Trauma ◽  
Selenium Deficiency ◽  
Infectious Complications ◽  
Selenium Level ◽  
Trauma Patients ◽  
Serum Selenium ◽  
Serum Selenium Levels ◽  
Multiple Trauma Patients ◽  
Serum Selenium Level ◽  
Low Serum

Low serum selenium levels are commonly observed in critically injured multiple trauma patients. This study aimed to identify the association between initial serum selenium levels and in-hospital infectious complications in multiple trauma patients. We retrospectively reviewed multiple trauma patients admitted between January 2015 and November 2017. We selected 135 patients whose serum selenium levels were checked within 48 h of admission. Selenium deficiency was defined as a serum selenium level <70 ng/mL. Survival analyses of selenium deficiency and 30-day mortality were performed. Multivariate logistic regression analysis was performed to identify the association between initial serum selenium level and in-hospital infectious complications. Thirty-day mortality (8.3% vs. 0.0%; p = 0.018) and incidence rates of pneumonia (66.7% vs. 28.3%; p < 0.001) and infectious complications (83.3% vs. 46.5%; p < 0.001) were higher in patients with selenium deficiency than in patients without selenium deficiency. Kaplan–Meier survival cures also showed similar results (log rank test, p = 0.021). Of 135 patients, 76 (56.3%) experienced at least one infectious complication during admission. High injury severity score (ISS, odds ratio (OR) 1.065, 95% confidence interval (CI) 1.024–1.108; p = 0.002) and selenium deficiency (OR 3.995, 95% CI 1.430–11.156; p = 0.008) increased the risk of in-hospital infectious complications in multiple trauma patients. Patients with selenium deficiency showed higher 30-day mortality and higher risks of pneumonia and infectious complications.

scholarly journals Serum Selenium Level Predicts 10-Year Survival after Breast Cancer

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 953
Author(s):  
Marek Szwiec ◽  
Wojciech Marciniak ◽  
Róża Derkacz ◽  
Tomasz Huzarski ◽  
Jacek Gronwald ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Survival ◽  
Survival Rates ◽  
Selenium Level ◽  
Serum Selenium ◽  
Breast Cancer Patients ◽  
Serum Selenium Levels ◽  
Serum Selenium Level

In a recent prospective study, we reported an association between a low serum selenium level and five-year survival among breast cancer patients. We now have updated the cohort to include 10-year survival rates. A blood sample was obtained from 538 women diagnosed with first primary invasive breast cancer between 2008 and 2015 in the region of Szczecin, Poland. Blood was collected before initiation of treatment. Serum selenium levels were quantified by mass spectroscopy. Each patient was assigned to one of four quartiles based on the distribution of serum selenium levels in the whole cohort. Patients were followed from diagnosis until death or last known alive (mean follow-up 7.9 years). The 10-year actuarial cumulative survival was 65.1% for women in the lowest quartile of serum selenium, compared to 86.7% for women in the highest quartile (p < 0.001 for difference). Further studies are needed to confirm the protective effect of selenium on breast cancer survival. If confirmed this may lead to an investigation of selenium supplementation on survival of breast cancer patients.

scholarly journals Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment

2014 ◽  
Vol 40 (3) ◽  
pp. 269-278 ◽  
Author(s):  
Milena Lima de Moraes ◽  
Daniela Maria de Paula Ramalho ◽  
Karina Neves Delogo ◽  
Pryscila Fernandes Campino Miranda ◽  
Eliene Denites Duarte Mesquita ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Selenium Level ◽  
Control Group ◽  
Smear Microscopy ◽  
Serum Selenium ◽  
Biochemical Tests ◽  
Muscle Area ◽  
Antituberculosis Treatment ◽  
Serum Selenium Levels ◽  
Serum Selenium Level

Objective: To determine whether serum selenium levels are associated with the conversion of bacteriological tests in patients diagnosed with active pulmonary tuberculosis after eight weeks of standard treatment. Methods: We evaluated 35 healthy male controls and 35 male patients with pulmonary tuberculosis, the latter being evaluated at baseline, as well as at 30 and 60 days of antituberculosis treatment. For all participants, we measured anthropometric indices, as well as determining serum levels of albumin, C-reactive protein (CRP) and selenium. Because there are no reference values for the Brazilian population, we used the median of the serum selenium level of the controls as the cut-off point. At 30 and 60 days of antituberculosis treatment, we repeated the biochemical tests, as well as collecting sputum for smear microscopy and culture from the patients. Results: The mean age of the patients was 38.4 ± 11.4 years. Of the 35 patients, 25 (71%) described themselves as alcoholic; 20 (57.0%) were smokers; and 21 (60.0%) and 32 (91.4%) presented with muscle mass depletion as determined by measuring the triceps skinfold thickness and arm muscle area, respectively. Of 24 patients, 12 (39.2%) were classified as moderately or severely emaciated, and 15 (62.5%) had lost > 10% of their body weight by six months before diagnosis. At baseline, the tuberculosis group had lower serum selenium levels than did the control group. The conversion of bacteriological tests was associated with the CRP/albumin ratio and serum selenium levels 60 days after treatment initiation. Conclusions: Higher serum selenium levels after 60 days of treatment were associated with the conversion of bacteriological tests in pulmonary tuberculosis patients.

scholarly journals Association between serum selenium levels and febrile seizures in Indian children: a case control study

2017 ◽  
Vol 4 (2) ◽  
pp. 553
Author(s):  
Sadia Syeda Khadria ◽  
Jaidev M. D. ◽  
Vidya K.
Keyword(s):  
Case Control Study ◽  
Febrile Illness ◽  
Febrile Seizures ◽  
Case Control ◽  
Selenium Level ◽  
Serum Selenium ◽  
Significant Difference ◽  
Serum Selenium Levels ◽  
Serum Selenium Level ◽  
Control Study

Background: Febrile seizures are the most common form of childhood seizures. Children are at particular risk for selenium deficiency. There was various hypothesis about the co-relation between selenium levels and febrile seizures. The aim of the present study was to determine whether there were any changes in serum selenium levels in children with febrile seizures when compared to children with febrile illness without seizures.Methods: This was a hospital based prospective case control study, consisting of 40 children (20 cases and 20 controls) aged between 6 months to 60 months. The serum selenium level was measured in each of them by atomic absorption spectrophotometer. Data was analysed by using frequency percentage and pearson’s chi square test.Results: Out of the 40 children included in the study, serum selenium level was lower in febrile seizure group (80%) when compared to controls (20%) which was statistically significant (P value: 0.003). Also, there was no statistically significant difference between males and females.Conclusions: In the present study, we found significantly low serum selenium levels in children with febrile seizures as compared to the children with febrile illness with no seizures. Decreased levels of selenium in children with febrile seizures may be the result of oxidative damage, occurring in the neuronal cells. In our study, a significant co-relation between low levels of selenium and febrile seizures have been observed in children. However, since the numbers are small, further studies with larger sample size are recommended.

Prognostic value of serum selenium level in cutaneous melanoma

1993 ◽  
Vol 3 (1) ◽  
pp. 47
Author(s):  
B. Dréno ◽  
C. Deffuant ◽  
P. Célérier ◽  
H. L. Boiteau ◽  
P. Litoux
Keyword(s):  
Cutaneous Melanoma ◽  
Prognostic Value ◽  
Selenium Level ◽  
Serum Selenium ◽  
Serum Selenium Level

LncRNA MIAT regulated by selenium and T-2 toxin increases NF-κB-p65 activation, promoting the progress of Kashin-Beck Disease

2020 ◽  
pp. 096032712097512
Author(s):  
Min Shi ◽  
Ying He ◽  
Ying Zhang ◽  
Xiaobo Guo ◽  
Jing Lin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Intervention Group ◽  
Serum Selenium ◽  
Sirna Transfection ◽  
Pathway Activation ◽  
Tnf Α ◽  
Selenium Treatment ◽  
Low Selenium ◽  
Serum Selenium Level ◽  
Beck Disease

LncRNA myocardial infarction associated transcript (MIAT) has been shown to be involved in osteoarthritis (OA), but its role in Kashin-Beck Disease (KBD) has rarely been reported. In this study, rats were administered with low selenium and/or T-2 toxin for 4 weeks to establish a KBD animal model. The serum selenium level, TNF-α and IL-1β contents, phosphorylated p65 (p-p65) and MIAT expression were increased in each intervention group. Next, we isolated the primary epiphyseal chondrocytes, and found that selenium treatment reversed the effects of T-2 toxin on chondrocyte injury, p-p65 and MIAT expression. In addition, MIAT overexpression or T-2 toxin treatment led to increased cell death, apoptosis, inflammation, NF-κB-p65 pathway activation and MIAT expression, which was rescued by selenium treatment or MIAT siRNA transfection. Our results suggested that lncRNA MIAT regulated by selenium and T-2 toxin increased the activation of NF-κB-p65, thus being involved in the progress of KBD. [Formula: see text]

scholarly journals Relationship Between Selenium Trace and Patient Outcome After Open-Heart Surgery

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Gohar Eslami ◽  
Roya Salehi ◽  
Hamidreza Samaee ◽  
Vallialah Habibi ◽  
Mohammad Shokrzadeh ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Heart Surgery ◽  
Acute Stress ◽  
Open Heart Surgery ◽  
Selenium Level ◽  
Serum Selenium ◽  
Open Heart ◽  
Duration Of Surgery ◽  
The Relationship ◽  
Serum Selenium Level

Background: Acute stress response to heart surgery can cause major morbidity in patients. The trace of selenium is useful for preventing heart damage. Although the trend of selenium changes is of high importance for body balance, the usefulness of routine use and effectiveness of this element for patients under open-heart surgery is still unclear. Objectives: This study aimed at assessing serum selenium level before and after open-heart surgery and the relationship between selenium trace and patient outcome. Methods: This prospective analytical study was performed on 100 patients undergoing open-heart surgery using cardiopulmonary bypass (CPB). In all patients, the serum level was measured at a predetermined time (before surgery and one and two days after surgery). Then, the relationship between serum selenium and patient outcome was assessed. Results: The mean serum selenium level in patients on admission was 72.90 ± 14.62 μg/L, one day after surgery was 71.20 ± 15.84 μg/L, and two days after surgery was 71.54 ± 15.97 μg/L. Serum selenium levels were inversely and significantly associated with age (r = -0.183; P = 0.034, 013) duration of surgery (r = -221 and P = 0.014), duration of intensive care unit stay (r = 0.204, P = 0.021), and duration of CPB (r = 0.223, P = 013). Conclusions: Based on this study’s results, a low level of selenium can affect patients’ outcomes after open-heart surgery.

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