Diabetic neuropathy, foot ulceration, peripheral vascular disease and potential risk factors among patients with diabetes in Bahrain : A nationwide primary care diabetes clinic-based study

Abstract Progressive hand interphalangeal joint (IPJ) osteoarthritis is associated with pain, reduced function and impaired quality of life. However, the evidence surrounding risk factors for IPJ osteoarthritis progression is unclear. Identifying risk factors for IPJ osteoarthritis progression may inform preventative strategies and early interventions to improve long-term outcomes for individuals at risk of IPJ osteoarthritis progression. The objectives of the study were to describe methods used to measure the progression of IPJ osteoarthritis and identify risk factors for IPJ osteoarthritis progression. MEDLINE, EMBASE, Scopus, and The Cochrane Library were searched from inception to 19th February 2020 (PROSPERO CRD42019121034). Eligible studies assessed potential risk factor/s associated with IPJ osteoarthritis progression. Risk of bias was assessed using a modified QUIPS Tool, and a best evidence synthesis was performed. Of eight eligible studies, all measured osteoarthritis progression radiographically, and none considered symptoms. Eighteen potential risk factors were assessed. Diabetes (adjusted mean difference between 2.06 and 7.78), and larger finger epiphyseal index in males (regression coefficient β = 0.202) and females (β = 0.325) were identified as risk factors (limited evidence). Older age in men and women showed mixed results; 13 variables were not risk factors (all limited evidence). Patients with diabetes and larger finger epiphyseal index might be at higher risk of radiographic IPJ osteoarthritis progression, though evidence is limited and studies are biased. Studies assessing symptomatic IPJ osteoarthritis progression are lacking.

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A DEEP INSIGHT ON DIABETIC NEUROPATHY: THE SILENT COMPLICATION OF DIABETES, WITH INPUTS ON ITS CAUSES, DIAGNOSIS, PATHWAYS, AND TREATMENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i12.28447 ◽

2018 ◽

Vol 11 (12) ◽

pp. 112 ◽

Cited By ~ 1

Author(s):

Nikita Saraswat ◽

Phool Chandra ◽

Neetu Sachan

Keyword(s):

Risk Factors ◽

Side Effects ◽

Diabetic Neuropathy ◽

Potential Risk ◽

Web Of Science ◽

Review Paper ◽

Common Complication ◽

Deep Insight ◽

Glucose Levels ◽

Potential Risk Factors

Background: The incidence of diabetic neuropathy (DNP) is a prominent complication for people suffering from diabetes. DNP is a common complication in patients suffering from diabetes, and it is affecting approximately more than 50% of the population where the nerves are affected by high glucose levels.Objective: The aim of the review paper is to inspect the complications, causes, diagnosis, pathogenesis, treatments, pathways, and management of DNP as all these factors play important role in the management of DNP. This paper also aims to identify the potential cures and the side effects if any associated with the commonly used treatments in conditions of DNP.Methods: The data collected for reviewing was by studying the published researchers from PubMed, Web of Science, Medline, Science Direct, Excerpta Medica Database, Cochrane, Elton B. Stephens Company (EBSCO), and Google open access publications from the year 1995–2017.Results: We have concluded on an interpretation that the drugs for treating DNP are managing the pain and controlling glucose levels but are reportedly causing major side effects. Hence, attention must be given to the potential risk factors for neuropathy and development of formulations with minimal side effects and a potential cure. We have focused on the recent researches, emerging problems, and techniques for identifying the patients suffering from DNP.Conclusion: The incidence of DNP is a prominent complication for people suffering from diabetes. Although the treatment available currently focusses on the pain management in DNP, attention must be given to the potential risk factors for neuropathy and development of formulations with minimal side effects and a potential cure.

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Peripheral Neuropathy and potential risk factors in patients with Diabetes Mellitus in Kano, Northwestern Nigeria

10.26226/morressier.617c37317c09fc044a97528d ◽

2021 ◽

Author(s):

Dr Raliyatu Aliyu ◽

Prof Andrew E Uloko ◽

Prof ID Gezawa

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Peripheral Neuropathy ◽

Potential Risk ◽

Patients With Diabetes ◽

Potential Risk Factors

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Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

Thrombosis and Haemostasis ◽

10.1055/s-0038-1645677 ◽

1990 ◽

Vol 63 (01) ◽

pp. 013-015 ◽

Cited By ~ 15

Author(s):

E J Johnson ◽

C R M Prentice ◽

L A Parapia

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Potential Risk ◽

Antithrombin Iii ◽

Arterial Disease ◽

Coagulation System ◽

Early Age ◽

Arterial Thromboembolism ◽

Potential Risk Factors ◽

Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

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