Predictive value of mid-trimester amniotic fluid high-sensitive C-reactive protein, ferritin, and lactate dehydrogenase for fetal growth restriction

AbstractObjective:To analyze the accuracy of ultrasound prediction of birth weight discordance (BWD) and the influence of chorionicity and fetal growth restriction (FGR) on ultrasound performance.Methods:Retrospective analysis of 176 twin pregnancies at a Portuguese tertiary center, between 2008 and 2014. Last ultrasound biometry was recorded. Cases with delivery before 24 weeks, fetal malformations, interval between last ultrasound and deliver >3 weeks, twin-to-twin transfusion syndrome and monoamniotic pregnancies were excluded. The accuracy of prediction of BWD was assessed using the area under the receiver-operating characteristics curve (AUC).Results:BWD ≥20% was present in 21.6% of twin pregnancies. EBW had the best predictive performance for BWD (AUC 0.838, 95%CI 0.760–0.916), with a negative predictive value of 86.9% and a positive predictive value of 51.3%. Chorionicity did not influence ultrasound performance. None of the biometric variables analyzed was predictive of BWD in pregnancies without FGR.Conclusion:The accuracy of ultrasound in the prediction of BWD is limited, particularly in pregnancies without fetal growth restriction. Clinical decisions should not rely on BWD alone.

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Amniotic fluid insulin-like growth factor binding protein 3 concentration as early indicator of fetal growth restriction

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2009.01.004 ◽

2009 ◽

Vol 144 (1) ◽

pp. 15-20 ◽

Cited By ~ 6

Author(s):

Geraldine Murisier-Petetin ◽

Sandrine Gremlich ◽

Francoise Damnon ◽

Danielle Reymondin ◽

Patrick Hohlfeld ◽

...

Keyword(s):

Growth Factor ◽

Amniotic Fluid ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Binding Protein ◽

Growth Restriction ◽

Insulin Like Growth Factor ◽

Early Indicator ◽

Factor Binding

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Predictive Value of C-reactive Protein, Lactate Dehydrogenase, Ferritin and D-dimer Levels in Diagnosing COVID-19 Patients: a Retrospective Study

Acta Informatica Medica ◽

10.5455/aim.2021.29.45-50 ◽

2021 ◽

Vol 29 (1) ◽

pp. 45

Author(s):

Ahmed Kaftan ◽

Majid Hussain ◽

Abdulhussein Algenabi ◽

Farah Naser ◽

Muslim Enaya

Keyword(s):

Retrospective Study ◽

Lactate Dehydrogenase ◽

Predictive Value ◽

C Reactive Protein ◽

Reactive Protein ◽

D Dimer

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Evaluation of Placental Perfusion Based on Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Its Predictive Value for Late-Onset Fetal Growth Restriction

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-0717-5275 ◽

2018 ◽

Vol 79 (04) ◽

pp. 396-401

Author(s):

Hui Shi ◽

Xianyue Quan ◽

Wen Liang ◽

Xinming Li ◽

Bin Ai ◽

...

Keyword(s):

Fetal Growth ◽

Predictive Value ◽

Fetal Growth Restriction ◽

Diffusion Weighted Imaging ◽

Uterine Artery ◽

Late Onset ◽

Late Pregnancy ◽

Growth Restriction ◽

Placental Perfusion ◽

Perfusion Fraction

Abstract Objective The aim of this study was to investigate placental blood perfusion in middle and late pregnancy and explore its predictive value for fetal growth restriction (FGR). Methods All pregnant women included in the study were examined using placental intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Three IVIM parameters (D, f, D*) were obtained for each pregnant woman and analyzed using Image J software. Perfusion fraction f is a radiological marker of placental perfusion. The pulsatility index (PI) of the uterine artery is used to indirectly evaluate placental function. Results f-values were significantly lower in the late-onset FGR group compared to the normal late pregnancy group (19.07 vs. 27.78%). In addition, uterine artery PI values were markedly increased in the late-onset FGR group compared to the normal late pregnancy group (1.96 vs. 1.03), and neonatal weight was significantly lower in the late-onset FGR group (2.75 vs. 3.18 kg). There was a significant positive correlation between f-value, uterine artery PI and neonatal weight (r = 0.968, p < 0.01; r = 0.959, p < 0.01). There was a significant negative correlation between f-value and age of gestation (r = − 0.534, p < 0.01). Conclusion Perfusion fraction f was strongly correlated with uterine artery blood flow resistance as measured by color Doppler and had a certain predictive value for late-onset FGR.

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