181. Predictive value of the sFlt-1/PlGF ratio in preecalmpsia with or without fetal growth restriction

2018 ◽  
Vol 13 ◽  
pp. S93
Author(s):  
Qian Huang ◽  
Xiaodan di ◽  
Junjie Bao, Huishu Liu
Keyword(s):  
Fetal Growth ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Plgf Ratio

The role of ultrasound in the prediction of birth weight discordance in twin pregnancies: are we there yet?

2018 ◽  
Vol 46 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Ana Raquel Neves ◽  
Filipa Nunes ◽  
Miguel Branco ◽  
Maria do Céu Almeida ◽  
Isabel Santos Silva
Keyword(s):  
Birth Weight ◽  
Fetal Growth ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Predictive Performance ◽  
Growth Restriction ◽  
Operating Characteristics ◽  
Tertiary Center ◽  
Fetal Malformations ◽  
Twin Pregnancies

AbstractObjective:To analyze the accuracy of ultrasound prediction of birth weight discordance (BWD) and the influence of chorionicity and fetal growth restriction (FGR) on ultrasound performance.Methods:Retrospective analysis of 176 twin pregnancies at a Portuguese tertiary center, between 2008 and 2014. Last ultrasound biometry was recorded. Cases with delivery before 24 weeks, fetal malformations, interval between last ultrasound and deliver >3 weeks, twin-to-twin transfusion syndrome and monoamniotic pregnancies were excluded. The accuracy of prediction of BWD was assessed using the area under the receiver-operating characteristics curve (AUC).Results:BWD ≥20% was present in 21.6% of twin pregnancies. EBW had the best predictive performance for BWD (AUC 0.838, 95%CI 0.760–0.916), with a negative predictive value of 86.9% and a positive predictive value of 51.3%. Chorionicity did not influence ultrasound performance. None of the biometric variables analyzed was predictive of BWD in pregnancies without FGR.Conclusion:The accuracy of ultrasound in the prediction of BWD is limited, particularly in pregnancies without fetal growth restriction. Clinical decisions should not rely on BWD alone.

scholarly journals Evaluation of Placental Perfusion Based on Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Its Predictive Value for Late-Onset Fetal Growth Restriction

2018 ◽  
Vol 79 (04) ◽  
pp. 396-401
Author(s):  
Hui Shi ◽  
Xianyue Quan ◽  
Wen Liang ◽  
Xinming Li ◽  
Bin Ai ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Diffusion Weighted Imaging ◽  
Uterine Artery ◽  
Late Onset ◽  
Late Pregnancy ◽  
Growth Restriction ◽  
Placental Perfusion ◽  
Perfusion Fraction

Abstract Objective The aim of this study was to investigate placental blood perfusion in middle and late pregnancy and explore its predictive value for fetal growth restriction (FGR). Methods All pregnant women included in the study were examined using placental intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Three IVIM parameters (D, f, D*) were obtained for each pregnant woman and analyzed using Image J software. Perfusion fraction f is a radiological marker of placental perfusion. The pulsatility index (PI) of the uterine artery is used to indirectly evaluate placental function. Results f-values were significantly lower in the late-onset FGR group compared to the normal late pregnancy group (19.07 vs. 27.78%). In addition, uterine artery PI values were markedly increased in the late-onset FGR group compared to the normal late pregnancy group (1.96 vs. 1.03), and neonatal weight was significantly lower in the late-onset FGR group (2.75 vs. 3.18 kg). There was a significant positive correlation between f-value, uterine artery PI and neonatal weight (r = 0.968, p < 0.01; r = 0.959, p < 0.01). There was a significant negative correlation between f-value and age of gestation (r = − 0.534, p < 0.01). Conclusion Perfusion fraction f was strongly correlated with uterine artery blood flow resistance as measured by color Doppler and had a certain predictive value for late-onset FGR.

Fetal growth restriction and perinatal adverse outcomes associated with extremely high values of the sFlt-1/PlGF ratio

2019 ◽  
Vol 17 ◽  
pp. S28-S29
Author(s):  
C. Villalaín ◽  
L. Valle ◽  
M. Mendoza ◽  
M. Vázquez-Fernández ◽  
A. Fernández Oliva ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Adverse Outcomes ◽  
Growth Restriction ◽  
Plgf Ratio

Diagnosis of preeclampsia and fetal growth restriction with the sFlt-1/PlGF ratio: Diagnostic accuracy of the automated immunoassay Kryptor®

2017 ◽  
Vol 8 ◽  
pp. 31-36 ◽  
Author(s):  
Lisa Antonia Dröge ◽  
Alice Höller ◽  
Laura Ehrlich ◽  
Stefan Verlohren ◽  
Wolfgang Henrich ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Automated Immunoassay ◽  
Plgf Ratio

Correlation of Kryptor and Elecsys® immunoassay sFlt-1/PlGF ratio on early diagnosis of preeclampsia and fetal growth restriction: A case-control study

2020 ◽  
Vol 20 ◽  
pp. 44-49 ◽  
Author(s):  
Elisa Simón ◽  
Ignacio Herraiz ◽  
Cecilia Villalaín ◽  
Paula Isabel Gómez-Arriaga ◽  
María Soledad Quezada ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Case Control Study ◽  
Case Control ◽  
Growth Restriction ◽  
Plgf Ratio ◽  
Control Study

sFlt ‐1/ PlGF ratio and timing of delivery in early‐onset fetal growth restriction with antegrade umbilical artery flow

2020 ◽  
Vol 56 (4) ◽  
pp. 549-556 ◽  
Author(s):  
M. S. Quezada ◽  
J. Rodríguez‐Calvo ◽  
C. Villalaín ◽  
P. I. Gómez‐Arriaga ◽  
A. Galindo ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Early Onset ◽  
Umbilical Artery ◽  
Growth Restriction ◽  
Artery Flow ◽  
Plgf Ratio

Predictive value of pregnancy-associated plasma protein-A (PAPP-A) and free beta-hCG on fetal growth restriction: results of a prospective study

2015 ◽  
Vol 293 (6) ◽  
pp. 1227-1233 ◽  
Author(s):  
Pietro Cignini ◽  
Laura Maggio Savasta ◽  
Ferdinando Antonio Gulino ◽  
Salvatore Giovanni Vitale ◽  
Lucia Mangiafico ◽  
...  
Keyword(s):  
Prospective Study ◽  
Fetal Growth ◽  
Plasma Protein ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Protein A ◽  
Growth Restriction ◽  
Beta Hcg ◽  
A Prospective Study

scholarly journals Pregnancy associated plasma protein A: an early predictor of fetal growth restriction

2021 ◽  
Vol 10 (12) ◽  
pp. 4517
Author(s):  
Pavan Bhargava Chandramohan ◽  
Sarita Agrawal ◽  
Chandrashekhar Shrivastava ◽  
Sarita Rajbhar ◽  
Prasanta Nayak ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Plasma Protein ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Protein A ◽  
Outcome Data ◽  
Adverse Outcomes ◽  
Growth Restriction ◽  
Low Levels ◽  
Sensitivity Specificity

Background: The aim of our study was to determine the association of low levels of pregnancy associated plasma protein-A (PAPP-A) levels estimated at 11-13+6weeks of gestation with fetal growth restriction (FGR).Methods: A prospective observational study of a total of 203 pregnant women with PAPP-A levels were followed up and the outcome data were collected at childbirth.Results: The incidence of FGR was 7.3%. A significant association was found between low levels of PAPP-A MoM (≤0.49) with FGR (p=0.000) with unadjusted odds ratio of 11.6. At PAPP-A multiples of median (MoM) ≤0.49, FGR had a median (Q1, Q3) of 0.46 (0.42, 1.54) versus 1.87 (0.59, 3.11) which was statistically significant (p=0.05) with moderate strength of prediction [minus 0.58 (95% CI, minus 1.113, minus 0.055), p=0.03]. At the cut-off considered in our study i.e., ≤0.49 MoM, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 73%, 81%, 23%, and 97% respectively with a positive LR of 3.82 and negative LR of 0.32. Karl Pearson’s correlation showed positive correlation (r=0.308, p<0.001) between PAPP-A MoM and birthweight and showed that for every unit increase in PAPP-A MoM, birthweight increased by 0.082 times (approximately 90 gm). We also found an association of low PAPP-A with pre-eclampsia, preterm delivery and increased caesarean delivery births.Conclusions: We conclude that low PAPP-A MoM levels are good reflectors of placental function and adverse outcomes. PAPP-A, a part of the dual marker, may be extrapolated for suspecting FGR. This could guide in instituting appropriate feto-maternal surveillance.

Sign in / Sign up

Export Citation Format

Share Document