Diagnostic accuracy of color doppler ultrasonography in evaluation of cervical lymph nodes in oral cancer patients

Purpose: This study evaluated the sensitivity, specificity, and diagnostic accuracy of Color Doppler Ultrasonography (CDUS) in patients with suspected retinal detachment (RD) who underwent surgery. Methods: In this prospective, observational clinical study, 65 eyes of 65 consecutive patients with suspected RD with opaque media were included. Following a standardized protocol, CDUS of the retina of the affected eye was performed. The sensitivity, specificity, and diagnostic accuracy of CDUS were determined and compared to the findings during surgery. Results: The mean age of patients (18 men and 47 women) was 52.36 years (range: 8–77 years). The sensitivity, specificity, and overall accuracy of ocular CDUS were 91.3%, 88.1%, and 89.2%, respectively. The false-negative rate (negative CDUS images but presence of RD at operation) was 3.1% (2/65) and the false-positive rate (positive CDUS images but absence of RD at operation) was 7.7% (5/65). Conclusion: CDUS of the retina could be considered as a promising tool in the diagnosis of RD in patients with opaque media.

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Practice variation in defining sentinel lymph nodes on lymphoscintigrams in oral cancer patients

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-014-2843-2 ◽

2014 ◽

Vol 41 (12) ◽

pp. 2249-2256 ◽

Cited By ~ 6

Author(s):

Géke B. Flach ◽

Annelies van Schie ◽

Birgit I. Witte ◽

Renato A. Valdés Olmos ◽

W. Martin C. Klop ◽

...

Keyword(s):

Oral Cancer ◽

Lymph Nodes ◽

Cancer Patients ◽

Practice Variation ◽

Sentinel Lymph Nodes ◽

Oral Cancer Patients

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Power Doppler Improves the Diagnostic Accuracy of Color Doppler Ultrasonography in Cold Thyroid Nodules: Follow-Up Results

Hormone Research in Paediatrics ◽

10.1159/000023427 ◽

1999 ◽

Vol 52 (1) ◽

pp. 19-24 ◽

Cited By ~ 30

Author(s):

G. Cerbone ◽

S. Spiezia ◽

A. Colao ◽

A. Di Sarno ◽

A.P. Assanti ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Doppler Ultrasonography ◽

Thyroid Nodules ◽

Color Doppler ◽

Power Doppler ◽

Color Doppler Ultrasonography ◽

Cold Thyroid Nodules

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Key architectural changes in tumor-negative lymph nodes from metastatic-free oral cancer patients are valuable prognostic factors

Clinical & Experimental Metastasis ◽

10.1007/s10585-013-9631-4 ◽

2014 ◽

Vol 31 (3) ◽

pp. 327-338 ◽

Cited By ~ 5

Author(s):

Marilena Vered ◽

Ginette Schiby ◽

Anna Schnaiderman-Shapiro ◽

Ilya Novikov ◽

Ibrahim O. Bello ◽

...

Keyword(s):

Prognostic Factors ◽

Oral Cancer ◽

Lymph Nodes ◽

Cancer Patients ◽

Oral Cancer Patients ◽

Negative Lymph Nodes

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Combined Evaluation of Matrix Metalloproteinases and their Inhibitors has Better Clinical Utility in Oral Cancer

The International Journal of Biological Markers ◽

10.5301/jbm.2011.6359 ◽

2011 ◽

Vol 26 (1) ◽

pp. 27-36 ◽

Cited By ~ 6

Author(s):

Ragini D. Singh ◽

Haridas Nilayangode ◽

Jayendra B. Patel ◽

Franky D. Shah ◽

Shilin N. Shukla ◽

...

Keyword(s):

Oral Cancer ◽

Diagnostic Accuracy ◽

Cancer Patients ◽

Sensitivity And Specificity ◽

Clinical Decision Making ◽

Health Hazard ◽

Plasma Concentrations ◽

Cervical Lymph Node Metastasis ◽

Incidence And Mortality ◽

Oral Cancer Patients

Background Oral cancer is a major health hazard worldwide with increasing incidence and mortality. Cervical lymph node metastasis is a major determinant of outcome in oral cancer. The matrix metalloproteinase (MMP) system is critically involved in invasion and metastasis. Assessment of MMPs and tissue inhibitors of MMPs (TIMPs) in certain combinations might have better clinical efficacy given their potential role in the metastatic process. Aim Plasma concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 in 50 controls and 75 oral cancer patients (nonmetastatic, n=54; metastatic, n=21) were evaluated to assess their investigative value and role in predicting the behavior of this malignancy. Methods The plasma concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 were quantified by ELISA. The best 2- and 3-marker combinations were calculated using the statistical software mROC. The diagnostic values for all the biomolecules as single markers and their combinations were estimated using the measures of diagnostic accuracy, i.e. the area under the ROC curve and the sensitivity and specificity at cutoff limits with the highest diagnostic accuracy and at the 95% limits of sensitivity and specificity, respectively. Results MMP-9, TIMP-1 and TIMP-2 were significantly elevated (p=0.000, p=0.013 and p=0.005, respectively) in oral cancer patients. MMP-9 emerged as the best single statistically significant marker in plasma for oral cancer detection. It showed an increase in diagnostic performance when tested in combination with MMP-2 and TIMP-2. The median plasma MMP-9 levels were elevated in both the metastatic and nonmetastatic groups compared with controls (p<0.004 and p<0.007, respectively). Conclusion The results indicated that plasma MMP and TIMP levels in relevant combinations may facilitate clinical decision-making for improved management of oral cancer patients and may provide important data for selecting patients for treatment with drugs that interfere with MMP and TIMP activities.

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Contrast-Enhanced Color Doppler Ultrasonography for Preoperative Evaluation of Sentinel Lymph Node in Breast Cancer Patients

Breast Care ◽

10.1159/000436958 ◽

2015 ◽

Vol 10 (5) ◽

pp. 331-335 ◽

Cited By ~ 16

Author(s):

Dionysios Dellaportas ◽

Andreas Koureas ◽

John Contis ◽

Panagis M. Lykoudis ◽

Irene Vraka ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Cancer Patients ◽

Doppler Ultrasonography ◽

Color Doppler ◽

Color Doppler Ultrasonography ◽

Contrast Enhanced Ultrasound ◽

Breast Cancer Patients ◽

Contrast Enhanced

Background: Sentinel lymph node (SLN) biopsy is the standard of care for breast cancer patients with non-palpable axillary lymph nodes. We evaluated the usefulness of contrast-enhanced ultrasonography in preoperative detection of malignant SLNs. Methods: 50 patients with breast cancer (median age: 60 years) underwent a color power Doppler ultrasonography with intravenous contrast (Sonovue®) preoperatively, and findings suggestive of metastatic disease to the SLN were documented. The final histopathological report and the radiological preoperative record were compared. Finally, the sensitivity, specificity and diagnostic accuracy of this evolving diagnostic modality were calculated. Results: Contrast-enhanced ultrasound scan identified a negative SLN in the axilla of 27 patients and final histopathology was negative for 30 cases in total, so negative predictive value was calculated as 90% and positive predictive value was 75%. Overall sensitivity was 83.33% and specificity was 84.38%. Moreover, the ability of contrast-enhanced ultrasound to differentiate between SLN status was only statistically significantly correlated with the actual final histopathological report (p < 0.001), while successful ultrasound prediction was not correlated with any factor. Conclusions: SLN status can be evaluated preoperatively using contrast-enhanced color Doppler ultrasonography with high accuracy.

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