scholarly journals Cytology of soft tissue tumors: Malignant spindle cell tumors

2008 ◽  
Vol 25 (3) ◽  
pp. 87
Author(s):  
Aruna Prayaga
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Spindle Cell Tumors

scholarly journals Bovine Papillomavirus DNA and S100 Profiles in Sarcoids and Other Cutaneous Spindle Cell Tumors in Horses

2016 ◽  
Vol 54 (1) ◽  
pp. 44-52 ◽  
Author(s):  
E. D. Epperson ◽  
W. L. Castleman
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Soft Tissue Sarcomas ◽  
Soft Tissue Tumors ◽  
Bovine Papillomavirus ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Spindle Cell Tumors ◽  
Tumor Types

Histopathologic differentiation between deep dermal or subcuticular equine sarcoids (ie, nodular sarcoids) and other spindle cell tumors in the dermis and subcutis such as peripheral nerve sheath tumors (PNSTs) can be challenging based on morphologic criteria alone. It has been proposed that polymerase chain reaction (PCR) for bovine papillomavirus (BPV) DNA and S100 immunohistochemistry be used as diagnostic tests to separate equine sarcoids from PNSTs. We reviewed 197 skin-associated spindle cell tumors (ie, soft tissue sarcomas), including PNSTs and sarcoids, received at the University of Florida between 1995 and 2013 and performed BPV PCR and S100 immunohistochemistry on archived paraffin-embedded tissues. We found that BPV DNA was demonstrable in 70% of the sarcoids, 59% of the PNSTs, 37% of the fibrosarcomas, and 22% of other tumors (myxosarcomas, fibromas, and other sarcomas) diagnosed on histomorphologic characteristics. Positive S100 staining was only seen in 12 tumors in the study (5 fibrosarcomas, 3 sarcoids, 2 PNSTs, and 2 other sarcomas). The results demonstrate that BPV is associated with many skin-associated spindle cell soft tissue tumors in horses in addition to sarcoids. S100 was rarely expressed in equine soft tissue sarcomas in the skin but was expressed in many tumor types, including PNSTs and sarcoids. Because 41% of the PNSTs classified by histomorphology in this study were BPV negative and 94% were S100 negative, it is reasonable to classify these as soft tissue sarcomas with nerve sheath tumor histomorphology rather than as either PNSTs or sarcoids.

Spindle cell tumors of bone and soft tissue in infants and children

2013 ◽  
pp. 23-40
Author(s):  
Lester J. Layfield ◽  
Carlos W. Bedrossian ◽  
Julia R. Crim ◽  
Lucio Palombini
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Infants And Children ◽  
Tumors Of Bone ◽  
Spindle Cell Tumors ◽  
In Infants And Children

Spindle Cell Lipoma of the Foot: A Case Report and Literature Review

1995 ◽  
Vol 16 (4) ◽  
pp. 220-226 ◽  
Author(s):  
Kevin R. Math ◽  
Helene Pavlov ◽  
Edward DiCarlo ◽  
Walther H. O. Bohne
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Imaging Features ◽  
Spindle Cell Lipoma ◽  
Imaging Evaluation ◽  
Presumptive Diagnosis ◽  
Pleomorphic Lipoma ◽  
Atypical Lipoma

Lipomas are among the most commonly encountered soft tissue tumors in clinical practice, though they are rare in the foot. Although a presumptive diagnosis is typically made clinically, those tumors with atypical clinical features may require radiological consultation. Difficulty arises when radiographic features are not typical of lipoma. We present a fatty soft tissue tumor of the foot with nonadipose elements on magnetic resonance imaging evaluation. Differentiation of lipoma variants (e.g., spindle cell lipoma, atypical lipoma, pleomorphic lipoma, lipoblastoma, angiolipoma) from liposarcoma based on imaging features is not possible, necessitating surgical resection for definitive histological diagnosis.

SMOOTH AND SKELETAL MUSCLE MYOSINS IN SPINDLE CELL TUMORS OF SOFT TISSUE

1985 ◽  
Vol 35 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Takashi Saku ◽  
Nobuo Tsuda ◽  
Masanobu Anami ◽  
Haruo Okabe
Keyword(s):  
Skeletal Muscle ◽  
Soft Tissue ◽  
Spindle Cell ◽  
Spindle Cell Tumors

scholarly journals Scope of FNAC in the diagnosis of soft tissue tumors-A study from a tertiary cancer referral center in India

CytoJournal ◽  
2007 ◽  
Vol 4 ◽  
pp. 20 ◽  
Author(s):  
Bharat Rekhi ◽  
Biru D Gorad ◽  
Anagha C Kakade ◽  
RF Chinoy
Keyword(s):  
Soft Tissue ◽  
Predictive Value ◽  
False Positive ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Diagnostic Tools ◽  
Round Cell ◽  
Cell Type ◽  
Metastatic Lesions ◽  
Spindle Cell Type

Background Fine needle aspiration cytology (FNAC) forms one of the first diagnostic tools in the evaluation of tumors. Its role in diagnosing soft tissue tumors (STT) has been fairly documented, as well as debated. Present study was aimed at evaluating its scope in diagnosing 127 cases of soft tissue tumors. Methods Conventional Pap and MGG staining was available in all the cases. Immunocytochemistry (ICC) was performed in 15 cases. Histopathological details were available in 115 cases. Results 50% cases were referred for a primary diagnosis, while 26.8% & 22.8% cases were evaluated for recurrent and metastatic lesions, respectively. Extremities were the commonest sites. On FNAC, 101 cases (79.5%) were labeled as malignant, whereas 10 cases (7.9%) were labeled as benign. The remaining 16 cases (11%) were not categorized and were labeled as ‘unsure/not specified’. Histopathological confirmation in 115 cases, gave a diagnostic accuracy of 98%, with a positive predictive value of 98% in malignant cases and a negative predictive value of 100% in benign cases. Two cases were false positive. Among the various cytological categories, 60 cases (47.2%) were of spindle cell type, followed by 32 (25.2%) of round cell type and 14 cases (11%) of lipomatous type. Other 12 cases (9.4%) were of pleomorphic type; 7 (5.5%) cases of epithelioid type and remaining 2 cases were of myxoid type. All the round cell, pleomorphic and myxoid type of tumors were sarcomas, whereas 73.3% cases of spindle cell type were labeled as ‘malignant’. Exact cytological sub typing was offered in 58 cases, with rhabdomyosarcoma (RMS) as the most frequently sub typed tumor. The two false positive malignant cases were of fibromatosis and a pigmented schwannoma, on biopsy. Out of 28 metastatic lesions, lymph nodes were the commonest site for metastasis, with epithelioid tumors that formed highest percentage of metastatic cases. Conclusion FNAC is fairly specific and sensitive in STT diagnoses for primary, recurrent and metastatic lesions. The cytological types, especially round cell and pleomorphic sarcomas, can be quickly identified. Clinicopathological correlation with ICC as an adjunct, are valuable in exact sub typing.

scholarly journals The histologic spectrum of soft tissue spindle cell tumors with NTRK3 gene rearrangements

2019 ◽  
Vol 58 (11) ◽  
pp. 739-746 ◽  
Author(s):  
Albert J. Suurmeijer ◽  
Brendan C. Dickson ◽  
David Swanson ◽  
Lei Zhang ◽  
Yun‐Shao Sung ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Gene Rearrangements ◽  
Spindle Cell Tumors

scholarly journals The Rapidly Expanding Group of RB1-Deleted Soft Tissue Tumors: An Updated Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 430
Author(s):  
Sasha Libbrecht ◽  
Jo Van Dorpe ◽  
David Creytens
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Adult Population ◽  
Suppressor Gene ◽  
Soft Tissue Tumors ◽  
Mesenchymal Tumors ◽  
Pleomorphic Liposarcoma ◽  
Molecular Features ◽  
Pleomorphic Lipoma ◽  
Older Adult Population

The classification of soft tissue tumors has evolved considerably in the last decade, largely due to advances in understanding the pathogenetic basis of many of these, sometimes rare, tumors. Deletion of Retinoblastoma 1 (RB1), a well-known tumor suppressor gene, has been implicated in the tumorigenesis of a particular group of soft tissue neoplasms. This group of so-called ”RB1-deleted soft tissue tumors” has been rapidly expanding in recent years, currently consisting of spindle cell/pleomorphic lipoma, atypical spindle cell/pleomorphic lipomatous tumor, pleomorphic liposarcoma, myofibroblastoma, cellular angiofibroma, and acral fibromyxoma. Most of these neoplasms, except pleomorphic liposarcoma, are considered benign entities and are mainly described in the older adult population. This article will review the currently known morphological, immunohistochemical, and molecular features of this heterogeneous group of mesenchymal tumors with an emphasis on differential diagnosis.

ALK rearrangements in infantile fibrosarcoma‐like spindle cell tumors of soft tissue and kidney

2021 ◽  
Author(s):  
Serena Y. Tan ◽  
Alyaa Al‐Ibraheemi ◽  
William A. Arhens ◽  
Javier E. Oesterheld ◽  
Julie C. Fanburg‐Smith ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Infantile Fibrosarcoma ◽  
Spindle Cell Tumors

scholarly journals An interesting case of spindle cell sarcoma of elbow

2020 ◽  
Vol 7 (8) ◽  
pp. 2781
Author(s):  
Sana Aboosalih ◽  
V. Shruthi Kamal ◽  
Surya Rao Venkata Mahipathy ◽  
Senthil Kumar Azhisoor Chandrasekhar ◽  
Balu Krishnamurthy Mahendra ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Ulnar Nerve ◽  
Spindle Cell ◽  
Ring Finger ◽  
Nerve Transfer ◽  
Soft Tissue Tumors ◽  
Interesting Case ◽  
Spindle Cell Sarcoma ◽  
Recurrent Nerve ◽  
Motor Branch

Spindle cell sarcomas are a group of aggressive malignant soft tissue tumors with a diverse clinical presentation. A 32 years old woman presented with a recurrent nerve sheath tumour, involving flexor carpi ulnaris and a portion of ulnar nerve. Wide local excision of the tumour was done creating a 4 cm gap defect in the ulnar nerve. Distal nerve transfer and Guyon’s canal release was done and anterior transposition of ulnar nerve to distal motor branch of ulnar nerve end to side (ETS) supercharge was done preserving motor function to the little and ring finger. Achieving negative surgical margins in primary soft tissue sarcoma is a critical for local disease control. The anatomical and functional compromise that can occur while giving adequate clearance margin for the tumor can be overcome by microsurgical techniques and neuroanastomosis with positive outcomes like preservation of function and better prognosis.

Sign in / Sign up

Export Citation Format

Share Document