scholarly journals Association of serum interleukin-6, interleukin-8, and Acute Physiology and Chronic Health Evaluation II score with clinical outcome in patients with acute respiratory distress syndrome

2016 ◽  
Vol 20 (9) ◽  
pp. 518-525 ◽  
Author(s):  
Deme Swaroopa ◽  
Kakarla Bhaskar ◽  
T. Mahathi ◽  
Shivakrishna Katkam ◽  
Y. Raju ◽  
...  
2014 ◽  
Vol 4 (2) ◽  
pp. 280-288 ◽  
Author(s):  
Julia L. Goldman ◽  
Saad Sammani ◽  
Carrie Kempf ◽  
Laleh Saadat ◽  
Eleftheria Letsiou ◽  
...  

2013 ◽  
Vol 138 (2) ◽  
pp. 266-269 ◽  
Author(s):  
Timothy Craig Allen ◽  
Anna Kurdowska

Acute lung injury is a complex clinical syndrome involving acute inflammation, microvascular damage, and increased pulmonary vascular and epithelial permeability, frequently resulting in acute respiratory failure culminating in often-fatal acute respiratory distress syndrome. Interleukin 8 (IL-8), a potent neutrophil attractant and activator, plays a significant role in acute lung injury via the formation of anti–IL-8 autoantibody:IL-8 complexes and those complexes' interaction with FcγRIIa receptors, leading to the development of acute lung injury by, among other possible mechanisms, effecting neutrophil apoptosis. These complexes may also interact with lung endothelial cells in patients with acute respiratory distress syndrome. Continuing research of the role of neutrophils, IL-8, anti–IL-8 autoantibody:IL-8 complexes, and FcγRIIa receptors may ultimately provide molecular therapies that could lower acute respiratory distress syndrome mortality, as well as reduce or even prevent the development of acute lung injury altogether.


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