scholarly journals Anti-lung cancer potential of pure esteric-glycoside condurangogenin A against nonsmall-cell lung cancer cells in vitro via p21/p53 mediated cell cycle modulation and DNA damage-induced apoptosis

2015 ◽  
Vol 11 (42) ◽  
pp. 73 ◽  
Author(s):  
AnisurRahman Khuda-Bukhsh ◽  
Sourav Sikdar ◽  
Avinaba Mukherjee
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Dna Damage ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells ◽  
Cell Cycle Modulation ◽  
Induced Apoptosis

Gold nanoparticle induces mitochondria-mediated apoptosis and cell cycle arrest in nonsmall cell lung cancer cells

Gold Bulletin ◽  
2017 ◽  
Vol 50 (2) ◽  
pp. 177-189 ◽  
Author(s):  
V. Ramalingam ◽  
S. Revathidevi ◽  
T. S. Shanmuganayagam ◽  
L. Muthulakshmi ◽  
R. Rajaram
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells ◽  
Cycle Arrest

scholarly journals Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 79
Author(s):  
Hengju Ge ◽  
Di Zhang ◽  
Muran Shi ◽  
Xiaoyuan Lian ◽  
Zhizhen Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Lung Cancer Cells ◽  
Potential Mechanism ◽  
Nucleotide Synthesis ◽  
Factor C ◽  
Antiglioma Activity

In 2019, streptoglutarimide H (SGH) was characterized as a new glutarimide from the secondary metabolites produced by a marine-derived actinomycete Streptomyces sp. ZZ741 and shown to have in vitro antiglioma activity. However, the antiproliferative activity and potential mechanism of SGH against lung cancer cells have not yet been characterized. This study demonstrated that SGH significantly inhibited the proliferation of different lung cancer cells. In terms of mechanism of action, SGH downregulated cell cycle- and nucleotide synthesis-related proteins to block cell cycle at G0/G1 phase, reduced the expression levels of glycolytic metabolic enzymes to inhibit glycolysis, and downregulated the important cancer transcription factor c-Myc and the therapeutic target deubiquitinase USP28. Potent anticancer activity and multiple mechanisms indicated SGH to be a novel antitumor compound against lung cancer cells.

scholarly journals In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability

2010 ◽  
Vol 43 (10) ◽  
pp. 1001-1009 ◽  
Author(s):  
A.O. Santos ◽  
J.P. Pereira ◽  
M.C. Pedroso de Lima ◽  
S. Simões ◽  
J.N. Moreira
Keyword(s):  
Lung Cancer ◽  
Cell Viability ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

scholarly journals Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119135 ◽  
Author(s):  
Mei-Chuan Tang ◽  
Mei-Yi Wu ◽  
Ming-Hung Hwang ◽  
Ya-Ting Chang ◽  
Hui-Ju Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells

scholarly journals THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism

2018 ◽  
Vol 40 (6) ◽  
pp. 814-822 ◽  
Author(s):  
Zhu-Jun Cheng ◽  
Du-Ling Miao ◽  
Qiu-Yun Su ◽  
Xiao-Li Tang ◽  
Xiao-Lei Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Cancer Metabolism ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung
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