Efficacy of alpha lipoic acid in adjunct with intralesional steroids and hyaluronidase in the management of oral submucous fibrosis

Objective: To compared efficacy of alpha lipoic acid (antioxidant medication) and aloe vera gel together versus intralesional steroids (hydrocortisone) in management of oral submucous fibrosis by evaluating post treatment clinical features of mouth opening and burning sensation. Study Design: A prospective comparative study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Malir Karachi, from Jul 2018 to Mar 2020. Methodology: Twenty-eight patients were involved in the research and were distributed into two groups, I and II. Alpha lipoid acid with aloe vera gel was given in group I and hydrocortisone was given in group II. Burning sensation and mouth opening were recorded both at start and at monthly interval later on for three consecutive months. The data collected were statistically analyzed by using SPSS-22. Results: A significant lessening in burning sensation (p<0.001) and improvement in mouth opening were noticed in both groups. However, comparison between alpha lipoic acid with aloe vera gel group versus hydrocortisone group showed almost similar results. Conclusion: Alpha lipoic acid and aloe vera gel can significantly improve oral submucous fibrosis clinically. So, these can be utilized as an alternative option in cases where intralesional steroid is poorly tolerated or is contraindicated.

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ORAL SUBMUCOUS FIBROSIS

The Professional Medical Journal ◽

10.29309/tpmj/2018.25.04.339 ◽

2018 ◽

Vol 25 (04) ◽

pp. 520-525

Author(s):

Muhammad Zeeshan ◽

Ayesha Shakeel ◽

Hafiz Yasir Mahmood ◽

Muhammad Zeeshan

Keyword(s):

Oral Submucous Fibrosis ◽

Computer Software ◽

Mouth Opening ◽

Cross Sectional Study ◽

P Value ◽

Areca Nut ◽

Chi Square ◽

Cross Sectional ◽

Submucous Fibrosis ◽

Intralesional Steroids

Objectives: In this study we investigate the effectiveness of lycopene in themanagement of oral submucous fibrosis (OSF) when intralesional steroids also given incombination. Study Design: Cross sectional study. Setting: Dental Section Allied Hospital,Faisalabad. Period: Eight months from September 2016 to April 2017. Methodology: This crosssectional study was initiated after approval from hospital ethical board. Collected Informationwas entered in SPSS computer software version 23 and analyzed for possible results. Meanand SD was calculated and presented for quantitative data like age, VAS score and mouthopening. Frequency (percentages) were calculated and presented for qualitative data such asgender. Post stratification statistical chi square test was used to see effect modification. P value≤ 0.05 was considered as significant. Results: Overall, there were 100% (n=354) patients.Total patients who were selected for the study had the habit of chewing areca nut either innatural form or in the form of Pan Masala, gutkha or mawa. Gutkha is the most common formof areca nut used, i.e. 65.8% (n=233) patients were using it. In our study average increase inmouth opening from baseline (before treatment) was 5.12±1.03 mm in group A. 4.20±1.26mm in group B and 3.40±0.19 mm in group C at six week. Conclusion: When Lycopene usedcombined with intralesional steroids and Hyaluronidase its effectiveness is better in improvingthe mouth opening its symptoms in patients with Oral Submucous Fibrosis (OSF). It was alsofound that there was no side effects.

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