Evaluation of nonsurgical periodontal therapy in chronic periodontitis patients with anemia by estimating hematological parameters and high-sensitivity C-reactive protein levels

Abstract Background: Although many studies have compared circulating IL-6 and CRP concentrations in periodontal patients and controls, a limited number of studies have compared systemic inflammatory markers at baseline and follow-up and also Data on whether periodontal therapy affects serum CRP levels are inconclusive. Aims and Objective: By the virtue of this study, an attempt was made to evaluate and compare the effect of non surgical periodontal therapy on serum C-Reactive Protein levels in Generalized chronic periodontitis patients. Material and Method: A total of thirty patients with Generalised chronic periodontitis, within the age range of 30-70 years, were selected and underwent non surgical periodontal therapy. Further, they were put on a two month follow up after post operative phase for evaluation and comparison of pre and post values. Results and Conclusion: The results of our study showed that non surgical periodontal therapy significantly reduces the serum levels of C-reactive protein along with other clinical parameters in patients with generalised chronic periodontitis.

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Effect of Periodontal Therapy on Serum C-Reactive Protein Levels in Patients with Gingivitis and Chronic Periodontitis: A Clinicobiochemical Study

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1305 ◽

2013 ◽

Vol 14 (2) ◽

pp. 233-237 ◽

Cited By ~ 10

Author(s):

Veena A Patil ◽

Manthan H Desai

Keyword(s):

Periodontal Disease ◽

Chronic Periodontitis ◽

Elevated Serum ◽

Periodontal Therapy ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Potential Biomarker ◽

Periodontal Index ◽

Serum Crp

ABSTRACT Aim The aim of the present study was to evaluate the effect of periodontal therapy on serum C-reactive protein (CRP) levels in patients with gingivitis and chronic periodontitis. Materials and methods A total of 60 subjects (30 males and 30 females) were included in the study with 20 subjects in each of the groups classified based on community periodontal index (CPI) scores: I: Healthy, II: Gingivitis, III: Mild periodontitis. Periodontal therapy was performed on groups II and III patients. Venous blood was collected from each subject at baseline and 3 months after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using immunoturbidimetric method. Results The present study demonstrated that the periodontitis group had a higher mean CRP levels (2.49 ± 0.47 ng/ml) as compared to the gingivitis group (1.40 ± 0.32 ng/ml) and healthy group (0.56 ± 0.20 ng/ml). The mean CRP values after periodontal therapy were found to be reduced to 0.44 ± 0.23 ng/ml in group II and 1.30 ± 0.36 ng/ml in group III patients. Conclusion Within the limitations of this study, it can be concluded that CRP level progressively increases from periodontal health to disease. A decrease in CRP levels with periodontal treatment was also observed. Clinical significance Due to its opsonizing abilities CRP plays an important role in the innate host defence. It can be hypothesized that CRP is a potential biomarker of periodontal disease. A number of studies have reported elevated serum CRP levels in periodontitis subjects. Long standing periodontal disease and raised CRP levels enhance the risk of cardiovascular disease, cerebrovascular accidents and preterm low birth weight infants. There is also evidence that effective periodontal therapy can lower serum CRP levels. However, the data of interventional studies on CRP in gingivitis and periodontitis is scarce. How to cite this article Patil VA, Desai MH. Effect of Periodontal Therapy on Serum C-Reactive Protein Levels in Patients with Gingivitis and Chronic Periodontitis: A Clinicobiochemical Study. J Contemp Dent Pract 2013;14(2):233-237.

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