Sarcomatoid carcinoma: A clinicopathological profile of two cases with diagnostic emphasis

Abstract Intracranial meningiomas are the most common extra-axial tumors, representing 15% of all brain tumors. Arising from the arachnoid cells, and common in middle-aged women, 90% meningiomas are benign. We conducted a 10-year study on 183 cases of intracranial meningiomas and observed a lower and decreasing trend; the mean age was 43.3 years but there was also a significant incidence in young females. Parasagittal/falx (29%), sphenoid ridge, convexity meningiomas and middle cranial fossa locations were more common. Histopathologically, meningothelial meningioma was the most common. Benign (WHO I) tumors were found in above 90%, atypical (WHO II) in 5% cases, and malignant (WHO III) in < 4% patients. Most patients underwent Simpsons Grade I excision (35.6%) with dural reconstruction because of late presentations. Posterior fossa meningiomas were mostly benign, while intraventricular ones were mostly malignant with highest postoperation mortality. Mortality in operated patients was 9.8% but was highest in anterior fossa tumors (12.5%).

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Primary Small Intestinal Sarcomatoid Carcinoma: Report of a Rare Case and Literature Review

Case Reports in Oncology ◽

10.1159/000514145 ◽

2021 ◽

pp. 538-544

Author(s):

Nozomi Karakuchi ◽

Senichiro Yanagawa ◽

Kei Kushitani ◽

Shinya Kodama ◽

Yukio Takeshima ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Early Stage ◽

Vena Cava ◽

Sarcomatoid Carcinoma ◽

Additional Treatment ◽

Intestinal Tumors ◽

Gastrointestinal Malignancies ◽

Node Metastasis ◽

Small Intestinal

Sarcomatoid carcinoma (SC) is a rare malignant tumor with properties of both epithelial and mesenchymal carcinomas. SC has been reported in various organs, but the number of reports for each type is small. Small intestinal tumors make up about 3–6% of gastrointestinal malignancies. Discovering them in the early stage is rare and difficult, with anemia and/or abdominal pain as the major symptoms of small intestinal tumors. Primary small intestinal SC (SISC) is rare among small intestinal tumors, and currently very few cases have been reported in the literature. Previous studies have reported that neither chemotherapy nor radiotherapy improves the overall survival rate of patients with SISC, and the prognosis is extremely poor. Currently, surgical resection remains the only optimal therapeutic approach for SISC. Here, we present the case of a 90-year-old woman who had acute peritonitis due to perforation of a small intestinal tumor. She underwent emergency exploratory laparotomy and partial resection of the small intestine, including the tumor. The tumor was pathologically identified as a primary SISC with mesenteric lymph node metastasis. Subsequently, she had recurrence in the intra-abdominal area and lymph node metastasis anterior to the inferior vena cava and died 15 months after surgery without any additional treatment.

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Testicular Metastatic Sarcomatoid Carcinoma of Unknown Primary: A Case Report

Ultrasound International Open ◽

10.1055/a-1304-5731 ◽

2020 ◽

Vol 06 (03) ◽

pp. E62-E65

Author(s):

Leo Nygaard ◽

Søren Rafael Rafaelsen ◽

Jan Lindebjerg ◽

Malene Roland Vils Pedersen

Keyword(s):

Case Report ◽

Sarcomatoid Carcinoma ◽

Unknown Primary ◽

Carcinoma Of Unknown Primary

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A RARE VARIANT OF SQUAMOUS CELL CARCINOMA: SARCOMATOID CARCINOMA

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2021.03.077 ◽

2021 ◽

Vol 132 (1) ◽

pp. e18

Author(s):

M Gormez ◽

E Cetin ◽

A Arici ◽

RD Koseoglu

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Rare Variant ◽

Squamous Cell ◽

Sarcomatoid Carcinoma

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Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽

10.1186/s12893-021-01099-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shangqing Ren ◽

Hualin Feng ◽

Yige Bao ◽

Yi Wei ◽

Yong Ou ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Urinary Tract ◽

Urothelial Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Standard Treatment ◽

Clinical Manifestations ◽

Sarcomatoid Carcinoma ◽

Upper Urinary Tract ◽

Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

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