Independent effect of body mass index on clinical pregnancy rate in single blastocyst frozen embryo transfer cycle in Asian women

Background The influence of anti-nuclear antibody (ANA) on induced ovulation was controversial, and the effect of prednisone plus hydroxychloroquine (HCQ) treatment on frozen embryo transfer outcomes of in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) for ANA-positive women was unclear. Methods Fifty ANA-positive women and one-hundred ANA-negative women matched for age and anti-Mullerian hormone (AMH) were included from a Reproductive Medical Central of a University Hospital. Sixty-one oocytes pick-up (OPU) cycles in ANA+ group and one-hundred OPU cycles in ANA− group were compared; 30 frozen embryo transfer cycles without treatment and 66 with prednisone plus HCQ treatment among ANA-positive women were compared. Results There was no statistical difference in number of retrieved oocytes (13.66 ± 7.71 vs 13.72 ± 7.23, p = .445), available embryos (5.23 ± 3.37 vs 5.47 ± 3.26, p = .347), high-quality embryos (3.64 ± 3.25 vs 3.70 ± 3.52, p = .832), and proportion of high-quality embryos (26.5% vs. 26.7%, p = .940). Biochemical pregnancy rate (33.3% vs. 68.2%, p < .05), clinical pregnancy rate (20.0% vs. 50.1%, p < .05), and implantation rate (5.6% vs. 31.8%, p < .05) were lower, and pregnancy loss rate (83.3% vs. 23.1%, p < .05) was higher in patients with treatment than no treatment. Conclusion The influence of ANA on number of retrieved oocytes, available embryos, high-quality embryos, and proration of high-quality embryos was not found. The treatment of prednisone plus HCQ may improve implantation rate, biochemical pregnancy rate, and clinical pregnancy rate, and reduce pregnancy loss rate in frozen embryo transfer outcomes for ANA-positive women.

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Effect of Female Body Mass Index on Clinical Pregnancy Rate After In Vitro Fertilization

Advanced Science Letters ◽

10.1166/asl.2017.9455 ◽

2017 ◽

Vol 23 (7) ◽

pp. 7009-7011 ◽

Cited By ~ 1

Author(s):

Shabrina Narasati ◽

Oki Riayati ◽

Budi Wiweko ◽

Achmad Kemal Harzif ◽

Gita Pratama ◽

...

Keyword(s):

Body Mass Index ◽

In Vitro Fertilization ◽

Pregnancy Rate ◽

Body Mass ◽

Female Body ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Vitro Fertilization ◽

Female Body Mass

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Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women with PCOS undergoing frozen embryo transfer

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2611-1 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Jiaying Lin ◽

Jialyu Huang ◽

Ningling Wang ◽

Yanping Kuang ◽

Renfei Cai

Keyword(s):

Body Mass Index ◽

Preterm Birth ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Body Mass ◽

Live Birth ◽

Low Birthweight ◽

Perinatal Outcomes ◽

Normal Weight ◽

Frozen Embryo Transfer

Abstract Background Previous studies have shown that among women with polycystic ovary syndrome who have difficulties conceiving, frozen-embryo transfer resulted in increased live birth rates and decreased ovarian hyperstimulation syndrome risk than did fresh-embryo transfer. In the present retrospective analysis, we sought to determine the effect of body mass index (BMI) on pregnancy and perinatal outcomes in women with PCOS undergoing FET. Methods Women with PCOS (n = 1556) undergoing FET were divided into groups based on weight, with those with normal weight having a BMI of 18.5–24.9 kg/m2,those who were overweight having a BMI of 25–29.9 kg/m2, and those who were obese having a BMI ≥30 kg/m2. Both pregnancy and perinatal outcomes were compared among these groups. Results The normal-weight, overweight, or obese groups exhibited similar pregnancy outcomes, including clinical pregnancy rate, miscarriage rate, ongoing pregnancy rate and live birth rate. In singletons, birth characteristics regarding newborn gender, gestational age, birthweight and length at birth were comparable between the three groups. For adverse neonatal outcomes, the three groups showed no significant differences on the rates of low birthweight, very low birthweight, preterm birth, and very preterm birth after adjustment. In addition, the obstetric complications and the frequencies of live-birth defects were also comparable between the three groups except that overweight and obese women were more likely than women of normal weight to have delivered via cesarean section. Conclusion BMI did not affect the pregnancy or perinatal outcomes in women with PCOS undergoing FET.

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RETROSPECTIVE STUDY TO COMPARE BETWEEN HYALURONAN ENRICHED MEDIUM AND BLASTOCYST TRANSFER MEDIUM FOR FROZEN EMBRYO TRANSFER( FET) AND ITS IMPACT ON CLINICAL PREGNANCY RATE (CPR) IN PATIENTS WITH 2 OR MORE IVF-ICSI CYCLE FAILURES

Fertility and Sterility ◽

10.1016/j.fertnstert.2020.08.527 ◽

2020 ◽

Vol 114 (3) ◽

pp. e185-e186

Author(s):

Fiyazur Rahman ◽

Ankita Gupta ◽

Dr. Rashmi Sharma ◽

Rohan Sharma ◽

Dr. Navkiran k Kaur

Keyword(s):

Retrospective Study ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

Blastocyst Transfer ◽

Icsi Cycle

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Fresh versus frozen embryo transfer: a retrospective cohort study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193814 ◽

2019 ◽

Vol 8 (9) ◽

pp. 3774

Author(s):

Raksha K. Shetty ◽

Purnima K. Nadkarni ◽

Pooja P. Singh ◽

Prabhakar Singh ◽

Aditi A. Nadkarni ◽

...

Keyword(s):

Cohort Study ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

Transfer Strategies

Background: Elective frozen embryo transfer (FET), has recently increased significantly with improvements in cryopreservation techniques. Observational studies and randomized controlled trials suggested that the endometrium in stimulated cycles is not optimally prepared for implantation; risk of ovarian hyperstimulation syndrome reduced and pregnancy rates increased following FET and perinatal outcomes are less affected after FET. However, the evidence is not unequivocal and recent randomised control trials challenge the use of elective FET for the general IVF population. Pregnancy rates were analysed in a cohort of patients undergoing embryo transfers.Methods: This was a retrospective cohort study of patients who underwent embryo transfers from April 2018 to March 2019 at study centre in Surat.175 cycles of embryo transfers (119 fresh and 56 frozen) were included in the study. Outcomes measured were positive pregnancy, clinical pregnancy and ongoing clinical pregnancy rates achieved in the IVF-ET cycles.Results: There were no statistically significant differences between positive pregnancy rate (54.6% versus 60.7%, Odds ratio (OR) 0.78; 95% Confidence Interval (CI) 0.41-1.49), clinical pregnancy rate (48.73% versus 57.14%, OR 0.52; 95% CI 0.1- 2.64) and ongoing clinical pregnancy rate (45.38% versus 51.78% OR 1.4; 95% CI 0.29 - 6.67) in fresh ET and FET cycles, respectively, p < 0.05 was considered statistically significant for all measures.Conclusions: Despite the observed higher rates of positive biochemical, clinical and ongoing clinical pregnancy per transfer in the FET cohort, these did not reach statistical significance. Thus, both transfer strategies are reasonable options, although there is a trend favouring the freeze-all strategy.

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