RETROSPECTIVE STUDY TO COMPARE BETWEEN HYALURONAN ENRICHED MEDIUM AND BLASTOCYST TRANSFER MEDIUM FOR FROZEN EMBRYO TRANSFER( FET) AND ITS IMPACT ON CLINICAL PREGNANCY RATE (CPR) IN PATIENTS WITH 2 OR MORE IVF-ICSI CYCLE FAILURES

Background The influence of anti-nuclear antibody (ANA) on induced ovulation was controversial, and the effect of prednisone plus hydroxychloroquine (HCQ) treatment on frozen embryo transfer outcomes of in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) for ANA-positive women was unclear. Methods Fifty ANA-positive women and one-hundred ANA-negative women matched for age and anti-Mullerian hormone (AMH) were included from a Reproductive Medical Central of a University Hospital. Sixty-one oocytes pick-up (OPU) cycles in ANA+ group and one-hundred OPU cycles in ANA− group were compared; 30 frozen embryo transfer cycles without treatment and 66 with prednisone plus HCQ treatment among ANA-positive women were compared. Results There was no statistical difference in number of retrieved oocytes (13.66 ± 7.71 vs 13.72 ± 7.23, p = .445), available embryos (5.23 ± 3.37 vs 5.47 ± 3.26, p = .347), high-quality embryos (3.64 ± 3.25 vs 3.70 ± 3.52, p = .832), and proportion of high-quality embryos (26.5% vs. 26.7%, p = .940). Biochemical pregnancy rate (33.3% vs. 68.2%, p < .05), clinical pregnancy rate (20.0% vs. 50.1%, p < .05), and implantation rate (5.6% vs. 31.8%, p < .05) were lower, and pregnancy loss rate (83.3% vs. 23.1%, p < .05) was higher in patients with treatment than no treatment. Conclusion The influence of ANA on number of retrieved oocytes, available embryos, high-quality embryos, and proration of high-quality embryos was not found. The treatment of prednisone plus HCQ may improve implantation rate, biochemical pregnancy rate, and clinical pregnancy rate, and reduce pregnancy loss rate in frozen embryo transfer outcomes for ANA-positive women.

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Closed vitrification system does not affect clinical pregnancy rate compared with fresh replacement in single blastocyst transfer program: a retrospective study

Fertility and Sterility ◽

10.1016/j.fertnstert.2015.07.598 ◽

2015 ◽

Vol 104 (3) ◽

pp. e193

Author(s):

S. Baillet ◽

A. Gala ◽

A. Ferrieres-Hoa ◽

C. Brunet ◽

C. Vincens ◽

...

Keyword(s):

Retrospective Study ◽

Pregnancy Rate ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Blastocyst Transfer ◽

Transfer Program ◽

Single Blastocyst Transfer

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Independent effect of body mass index on clinical pregnancy rate in single blastocyst frozen embryo transfer cycle in Asian women

Fertility Science and Research ◽

10.4103/fsr.fsr_14_19 ◽

2019 ◽

Vol 6 (2) ◽

pp. 115

Author(s):

TejashriM Shrotri ◽

Neeti Tiwari ◽

ShwetaMittal Gupta ◽

Ruma Satwik ◽

Gaurav Majumdar ◽

...

Keyword(s):

Body Mass Index ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Body Mass ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

Independent Effect ◽

Asian Women

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Fresh versus frozen embryo transfer: a retrospective cohort study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193814 ◽

2019 ◽

Vol 8 (9) ◽

pp. 3774

Author(s):

Raksha K. Shetty ◽

Purnima K. Nadkarni ◽

Pooja P. Singh ◽

Prabhakar Singh ◽

Aditi A. Nadkarni ◽

...

Keyword(s):

Cohort Study ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

Transfer Strategies

Background: Elective frozen embryo transfer (FET), has recently increased significantly with improvements in cryopreservation techniques. Observational studies and randomized controlled trials suggested that the endometrium in stimulated cycles is not optimally prepared for implantation; risk of ovarian hyperstimulation syndrome reduced and pregnancy rates increased following FET and perinatal outcomes are less affected after FET. However, the evidence is not unequivocal and recent randomised control trials challenge the use of elective FET for the general IVF population. Pregnancy rates were analysed in a cohort of patients undergoing embryo transfers.Methods: This was a retrospective cohort study of patients who underwent embryo transfers from April 2018 to March 2019 at study centre in Surat.175 cycles of embryo transfers (119 fresh and 56 frozen) were included in the study. Outcomes measured were positive pregnancy, clinical pregnancy and ongoing clinical pregnancy rates achieved in the IVF-ET cycles.Results: There were no statistically significant differences between positive pregnancy rate (54.6% versus 60.7%, Odds ratio (OR) 0.78; 95% Confidence Interval (CI) 0.41-1.49), clinical pregnancy rate (48.73% versus 57.14%, OR 0.52; 95% CI 0.1- 2.64) and ongoing clinical pregnancy rate (45.38% versus 51.78% OR 1.4; 95% CI 0.29 - 6.67) in fresh ET and FET cycles, respectively, p < 0.05 was considered statistically significant for all measures.Conclusions: Despite the observed higher rates of positive biochemical, clinical and ongoing clinical pregnancy per transfer in the FET cohort, these did not reach statistical significance. Thus, both transfer strategies are reasonable options, although there is a trend favouring the freeze-all strategy.

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Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves clinical pregnancy rate

Fertility and Sterility ◽

10.1016/j.fertnstert.2017.07.1038 ◽

2017 ◽

Vol 108 (3) ◽

pp. e355

Author(s):

S. Alur-Gupta ◽

M. Hopeman ◽

D.S. Berger ◽

K.T. Barnhart ◽

S. Senapati ◽

...

Keyword(s):

Pregnancy Rate ◽

Embryo Transfer ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

Serum Estradiol

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Serum estradiol level on trigger day impacts clinical pregnancy rate in modified natural frozen embryo transfer cycles

International Journal of Gynecology & Obstetrics ◽

10.1002/ijgo.12806 ◽

2019 ◽

Vol 145 (3) ◽

pp. 312-318 ◽

Cited By ~ 1

Author(s):

Fariba Ramezanali ◽

Arezoo Arabipoor ◽

Maryam Hafezi ◽

Reza Salman‐Yazdi ◽

Zahra Zolfaghari ◽

...

Keyword(s):

Pregnancy Rate ◽

Embryo Transfer ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

Estradiol Level ◽

Serum Estradiol ◽

Serum Estradiol Level

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Progesterone levels on the human chorionic gonadotropin trigger day affect the pregnancy rates for embryos transferred at different stages of development in both general and selected IVF/ICSI populations

10.21203/rs.3.rs-34461/v1 ◽

2020 ◽

Author(s):

Philippe Merviel ◽

Sarah Bouée ◽

Anne-Solenn Jacamon ◽

Jean-Jacques Chabaud ◽

Marie-Thérèse Le Martelot ◽

...

Keyword(s):

General Population ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Predictive Factors ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Blastocyst Transfer ◽

Progesterone Level ◽

Serum Progesterone

Abstract Background Two meta-analyses have shown that pregnancy and birth rates are significantly higher after blastocyst transfer than after cleaved embryo transfer. Other studies have revealed that a serum progesterone level > 1.5 ng/ml on the trigger day is responsible for premature luteinization and is associated with a low pregnancy rate. The objectives of the present study were to determine whether blastocyst transfer gave higher pregnancy rates than cleaved embryo transfer at day 3 in both the general and selected IVF/ICSI populations, and whether the serum progesterone level influenced the pregnancy rate. Method : We studied IVF/ICSI cycles with GnRH antagonist - FSH/hMG protocols in a general population (n = 1210) and a selected “top cycle” population (n = 677), after blastocyst transfer on D5 or cleaved embryo transfer on D3. The selected cycles had to meet the following criteria: female age < 35, first or second cycle, and one or two embryos transferred. We recorded predictive factors for pregnancy and calculated the serum progesterone to oocyte ratio (P/Ooc), the serum progesterone to serum estradiol ratio (P/E2), and the serum progesterone to follicle (> 14 mm) index (PFI). Results In the general population, the clinical pregnancy rate was significantly higher after blastocyst transfer (33.3%) than after cleaved embryo transfer (25.3%; p < 0.01). The differences between blastocyst and embryo transfer groups were not significant in the selected population (respectively 35.7% vs. 35.8% for the clinical pregnancy rate). The only predictive factors common to the general and selected populations were the serum progesterone levels on the eve of the trigger day and on the day itself, which were significantly lower in the subgroups of women who became pregnant (p < 0.01). We found a serum progesterone threshold of 0.9 ng/ml, as also reported by other studies. The P/Ooc ratio and the PFI appear to have predictive value for cleaved embryos transfers. Conclusions Blastocyst transfers were associated with higher clinical pregnancy rate than cleaved embryo transfers in a general population but not in a selected population. The serum progesterone levels on the eve of the trigger day and on the day itself predicted the likelihood of pregnancy.

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