Utility of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, mean platelet volume–platelet count ratios: Diagnostic and prognostic markers in patients with hepatocellular carcinoma, prostate carcinoma, stomach carcinoma, and aplastic anemia

Abstract Background hepatocellular carcinoma (HCC), a highly prevalent and lethal cancer, it is the sixth most common cancer and the third leading cause of cancer-related death worldwide. Aim of the work to evaluate the role of inflammatory markers Neutrophil lymphocyte ratio and Platelet lymphocyte ratio (NLR & PLR) as biomarkers for diagnosis of HCV related HCC. Patients and Methods this study was conducted in tropical medicine department, HCC clinic Ain-shams university hospitals. Our study included 174 candidates who were divided into three groups. Group A included 60 Patients with HCV-related HCC diagnosed according to American Association for the Study of Liver Diseases (AASLD) guidelines; HCC patients were subdivided into three subgroups According to BCLC Results group A included 114 Patients with HCV-related HCC, which was subdivided into three subgroups according to BCLC. Group 1 included 30 patients underwent Radio-frequency ablation (RF), 76.67% of them were males while 23.33% were females with mean age 57.433. Group 2 included 41 patients underwent Trans-arterial chemo-embolization (TACE), 80.49% were males while 19.51% were females with mean age 60.268. Group 3 included 43 Patients with BCLC stage C and D For best supportive care, 76.74% were males while 23.26% were females with mean age 60.372. Male to female ratio in HCC patients was 3.56:1. Conclusion AFP remains the gold standard marker for diagnosis of HCC. NLR and PLR has no role as early prognostic markers for HCC.

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Mean Platelet Volume and Neutrophil/Lymphocyte Ratio among Patients with Ulcerative Colitis as an Indicator of Activation

Lokman Hekim Health Sciences ◽

10.14744/lhhs.2021.70006 ◽

2021 ◽

Vol 1 (1) ◽

pp. 1-4

Author(s):

Kadir Serkan Yalcin

Keyword(s):

Ulcerative Colitis ◽

Platelet Count ◽

Mean Platelet Volume ◽

Complete Blood Count ◽

Activity Index ◽

Platelet Volume ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Wbc Count ◽

Two Parameters

Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in activation period among patients with ulcerative colitis (UC). Methods: Overall, 83 patients (49 female and 34 male) diagnosed with UC were retrospectively screened and includ- ed in this study. The complete blood count results, including hemoglobin, white blood cell (WBC) count, NLR, platelet count, and MPV, of all patients were recorded in both activation and remission periods. The serum C-reactive protein (CRP) and sedimentation levels of all patients were also recorded. Endoscopic disease activities (endoscopic activity index (EAI)) were also noted. Results: Compared with the remission periods, MPV values were statistically significantly lower (p=0.023) and NLR values were statistically significantly higher (p=0.011) in activation periods. In the correlation analysis, MPV levels were correlated with disease age (p=0.019), hemoglobin (p=0.012), WBC count (p=0.009), platelet count (p=0.001), sedimentation rate (p=0.001), CRP levels (p=0.009), and EAI (p=0.008) during activation periods. Conversely, the NLR did not correlate with MPV, hemoglobin, WBC, platelet count, or sedimentation and CRP levels; however, the NLR was also correlated with EAI (p=0.036). Discussion and Conclusion: We have studied two inexpensive, easily applicable, and noninvasive serum biomarkers, MPV and NLR, to determine UC activation and found that these two parameters are well correlated with other inflam- matory markers and EAI.

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Comparison of the Effects of Second Generation Antihistamines and Omalizumab Treatment on Neutrophil / Lymphocyte Ratio, Platelet / Lymphocyte Ratio and Mean Platelet Volume in Patients with Chronic Spontaneous Urticaria with Each Other and with the Control Group

10.22541/au.162503791.13626441/v1 ◽

2021 ◽

Author(s):

ZÜLKÜF ARSLAN ◽

CEMAL BİLAÇ

Keyword(s):

Platelet Count ◽

Neutrophil Count ◽

Mean Platelet Volume ◽

Chronic Spontaneous Urticaria ◽

Control Group ◽

Platelet Volume ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Platelet Lymphocyte Ratio ◽

Pre Treatment

ABSTRACT Objective: Studies have shown that neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and mean platelet volume (MPV) can be used in CSU to evaluate inflammation marker and response to treatment. In our study, we aimed to compare the NLR, PLR and MPV values in the control group and pre-treatment patient groups, and to investigate the changes with antihistamine treatment and omalizumab treatment in the CSU patient group and control group. Materials and Methods: 146 patients who applied to Manisa Celal Bayar University Dermatology and Venereal Diseases outpatient clinic, with a diagnosis of chronic spontaneous urticaria, using antihistamine or omalizumab were included in the study. Results: The neutrophil and NLR values of the antihistamine and omalizumab treatment group with CSU diagnosis were found to be significantly higher than the pre-treatment control group, but there was no significant difference between each other. Platelet count was found higher and MPV value was found lower in omalizumab group compare to control group. In the omalizumab group, a significant decrease in neutrophil count and platelet count was measured at 3rd months. Conclusion: Neutrophil count, platelet count, NLR values were higher and MPV values were found to be low compared to the control group, these values can be used to measure disease activity. After the treatment, a significant decrease in neutrophil count and platelet count was detected in the omalizumab group. In addition to its anti-IgE effect, omalizumab can show its anti-inflammatory effect by reducing the neutrophil count and platelet count to be within the normal range.

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Neutrophil Lymphocyte Ratio to Albumin Ratio and White Blood Cell to Hemoglobin Ratio as Prognostic Markers for Hepatocellular Carcinoma Patients Who Underwent Curative Hepatectomy

International Journal of General Medicine ◽

10.2147/ijgm.s329911 ◽

2021 ◽

Vol Volume 14 ◽

pp. 5029-5038

Author(s):

Xueqin Shen ◽

Wei Wang ◽

Xiaoping Niu

Keyword(s):

Hepatocellular Carcinoma ◽

Blood Cell ◽

White Blood Cell ◽

Prognostic Markers ◽

Albumin Ratio ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Curative Hepatectomy

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Utility of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume as predective and prognostic markers in patients with liver abscess in a tertiary care center in India

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2018.04.3551 ◽

2018 ◽

Vol 73 ◽

pp. 56

Author(s):

V. Srikanth ◽

D. Pillai ◽

S. Vasudevan

Keyword(s):

Liver Abscess ◽

Mean Platelet Volume ◽

Prognostic Markers ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Center ◽

Platelet Volume ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Platelet Lymphocyte Ratio

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Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190206125545 ◽

2019 ◽

Vol 19 (6) ◽

pp. 859-865 ◽

Cited By ~ 1

Author(s):

Faruk Kutluturk ◽

Serdar S. Gul ◽

Safak Sahin ◽

Turker Tasliyurt

Keyword(s):

Platelet Count ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Mean Platelet Volume ◽

Papillary Thyroid ◽

Platelet Volume ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Platelet Size ◽

The Mean

Introduction:Thyroid hormones are essential for the normal development, differentiation, metabolic balance and physiological function of all tissues. Mean platelet volume (MPV) indicates mean platelet size and reflects platelet production rate and stimulation. Increased platelet size has been observed in association with known cardiovascular risk factors. The neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are known markers of the systemic inflammatory response. This study aimed to investigate the effect of thyroid hormone changes by comparing platelet count, MPV values, NLR and PLR in thyroid papillary carcinoma.Methods:Forty-nine females and nine males comprising a total of 58 patients were included in the study. Clinical and laboratory parameters of patients were recorded in the following three phases of the disease: euthyroid phase (before thyroid surgery), overt hypothyroid (OH) phase (before radioactive iodine [RAI] treatment) and subclinical hyperthyroid (SCH) phase (six months after RAI treatment).Results:The mean thyroid-stimulating hormone (TSH) values of the patients in the euthyroid, OH and SCH phases were 1.62±1.17, 76.4±37.5 and 0.09±0.07 μIU/mL, respectively. The mean MPV values of the patients in the euthyroid, OH and SCH phases were 9.45±1.33, 9.81±1.35 and 9.96±1.21 fL, respectively. MPV was significantly higher in the SCH phase than in the euthyroid phase (p=0.013). Platelet count, NLR and PLR were not statistically different between the euthyroid, OH and SCH phases.Conclusion:The results of this study demonstrated that the levels of MPV increased significantly in the SCH phase in patients with papillary thyroid carcinoma (PTC), and increased MPV values contributed to increased risk of cardiovascular complications. These findings suggest that MPV can be a valuable, practical parameter for monitoring the haemostatic condition in thyroid disorders. No significant difference was observed in platelet count, NLR and PLR in all stages of PTC.

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