scholarly journals Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma

2019 ◽  
Vol 19 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Faruk Kutluturk ◽  
Serdar S. Gul ◽  
Safak Sahin ◽  
Turker Tasliyurt
Keyword(s):  
Platelet Count ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Mean Platelet Volume ◽  
Papillary Thyroid ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Size ◽  
The Mean

Introduction:Thyroid hormones are essential for the normal development, differentiation, metabolic balance and physiological function of all tissues. Mean platelet volume (MPV) indicates mean platelet size and reflects platelet production rate and stimulation. Increased platelet size has been observed in association with known cardiovascular risk factors. The neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are known markers of the systemic inflammatory response. This study aimed to investigate the effect of thyroid hormone changes by comparing platelet count, MPV values, NLR and PLR in thyroid papillary carcinoma.Methods:Forty-nine females and nine males comprising a total of 58 patients were included in the study. Clinical and laboratory parameters of patients were recorded in the following three phases of the disease: euthyroid phase (before thyroid surgery), overt hypothyroid (OH) phase (before radioactive iodine [RAI] treatment) and subclinical hyperthyroid (SCH) phase (six months after RAI treatment).Results:The mean thyroid-stimulating hormone (TSH) values of the patients in the euthyroid, OH and SCH phases were 1.62±1.17, 76.4±37.5 and 0.09±0.07 μIU/mL, respectively. The mean MPV values of the patients in the euthyroid, OH and SCH phases were 9.45±1.33, 9.81±1.35 and 9.96±1.21 fL, respectively. MPV was significantly higher in the SCH phase than in the euthyroid phase (p=0.013). Platelet count, NLR and PLR were not statistically different between the euthyroid, OH and SCH phases.Conclusion:The results of this study demonstrated that the levels of MPV increased significantly in the SCH phase in patients with papillary thyroid carcinoma (PTC), and increased MPV values contributed to increased risk of cardiovascular complications. These findings suggest that MPV can be a valuable, practical parameter for monitoring the haemostatic condition in thyroid disorders. No significant difference was observed in platelet count, NLR and PLR in all stages of PTC.

scholarly journals Assessment of the Neutrophil Lymphocyte Ratio and Mean Platelet Volume in Pregnancy

2020 ◽  
Vol 5 (1) ◽  
pp. 85-93
Author(s):  
Rendy Singgih ◽  
Yohanes Firmansyah
Keyword(s):  
Roc Curve ◽  
Mean Platelet Volume ◽  
Statistical Tests ◽  
P Value ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Hypertension In Pregnancy ◽  
The Mean ◽  
In Pregnancy

Abstract Introduction:  Hypertension in pregnancy is a common complication that affects maternal and fetal morbidity and mortality. Comprehensive handling is needed to overcome the incidence of hypertension in pregnancy so that it does not get worse. The use of inflammatory markers is widely used as a predictor of the incidence of hypertension in pregnancy, especially preeclampsia. Neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) values are believed to predict the incidence of hypertension in pregnancy. Aim of study: The purpose of this study was to determine the ability of both the NLR and MPV values to predict the incidence of hypertension in pregnancy. Methods: This research is an analytic observational study using secondary data from medical records. The data were taken from the Cimacan Regional Hospital from January to December 2019. The variables were then tested statistically to see the difference in the mean. If there are significant results, the predictor's ability will be tested again with the ROC curve test. Results: The results of statistical tests between the normotensive pregnancy group and pregnancy with hypertension showed that the mean difference was significant in the NLR variable with P-value of 0.004 and MPV with a P-value of 0.005. Then the NLR and MPV values were tested again by the ROC Curve method. The AUC results on the NLR variable (AUC: 0.562 / p-value: 0.022) and MPV (AUC: 0.560 / p-value: 0.022). Conclusion: Although NLR and MPV had differences mean between the two groups, their ability to predict pregnancy with hypertension was very low.   Keywords: Pregnancy; Hypertension; Preeclampsia; NLR; MPV.

Evidence of Phylogenetic Canalisation of the Circulating Platelet Mass in Man

1972 ◽  
Vol 27 (01) ◽  
pp. 159-172 ◽  
Author(s):  
W. E von Behrens
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Total Mass ◽  
Prognostic Significance ◽  
Platelet Volume ◽  
Platelet Size ◽  
Biochemical Function ◽  
Objective Classification ◽  
The Mean ◽  
Platelet Mass

SummaryPhylogenetically mammalian platelets are an apocrine secretion from nucleated thrombocytes, and biologically the number of circulating fragments is irrelevant compared with their total mass and biochemical function. The literature on human genetic derangements affecting the circulating platelet mass is reviewed. The product of platelet count and platelet volume is shown to be “canalised” since many congenital forms of thrombocytopenia are associated with a reciprocal increase in the mean platelet volume. Considerations of platelet size are essential since macrothrombocytopenia is a racial characteristic of many Mediterranean peoples and probably also occurs frequently in others races. The location of platelet disorders in relation to the phylogenetic canal provides an objective classification which has diagnostic, therapeutic and prognostic significance.

scholarly journals Mean Platelet Volume and Neutrophil/Lymphocyte Ratio among Patients with Ulcerative Colitis as an Indicator of Activation

2021 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Kadir Serkan Yalcin
Keyword(s):  
Ulcerative Colitis ◽  
Platelet Count ◽  
Mean Platelet Volume ◽  
Complete Blood Count ◽  
Activity Index ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Wbc Count ◽  
Two Parameters

Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in activation period among patients with ulcerative colitis (UC). Methods: Overall, 83 patients (49 female and 34 male) diagnosed with UC were retrospectively screened and includ- ed in this study. The complete blood count results, including hemoglobin, white blood cell (WBC) count, NLR, platelet count, and MPV, of all patients were recorded in both activation and remission periods. The serum C-reactive protein (CRP) and sedimentation levels of all patients were also recorded. Endoscopic disease activities (endoscopic activity index (EAI)) were also noted. Results: Compared with the remission periods, MPV values were statistically significantly lower (p=0.023) and NLR values were statistically significantly higher (p=0.011) in activation periods. In the correlation analysis, MPV levels were correlated with disease age (p=0.019), hemoglobin (p=0.012), WBC count (p=0.009), platelet count (p=0.001), sedimentation rate (p=0.001), CRP levels (p=0.009), and EAI (p=0.008) during activation periods. Conversely, the NLR did not correlate with MPV, hemoglobin, WBC, platelet count, or sedimentation and CRP levels; however, the NLR was also correlated with EAI (p=0.036). Discussion and Conclusion: We have studied two inexpensive, easily applicable, and noninvasive serum biomarkers, MPV and NLR, to determine UC activation and found that these two parameters are well correlated with other inflam- matory markers and EAI.

scholarly journals Comparison of the Effects of Second Generation Antihistamines and Omalizumab Treatment on Neutrophil / Lymphocyte Ratio, Platelet / Lymphocyte Ratio and Mean Platelet Volume in Patients with Chronic Spontaneous Urticaria with Each Other and with the Control Group

2021 ◽  
Author(s):  
ZÜLKÜF ARSLAN ◽  
CEMAL BİLAÇ
Keyword(s):  
Platelet Count ◽  
Neutrophil Count ◽  
Mean Platelet Volume ◽  
Chronic Spontaneous Urticaria ◽  
Control Group ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Pre Treatment

ABSTRACT Objective: Studies have shown that neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and mean platelet volume (MPV) can be used in CSU to evaluate inflammation marker and response to treatment. In our study, we aimed to compare the NLR, PLR and MPV values in the control group and pre-treatment patient groups, and to investigate the changes with antihistamine treatment and omalizumab treatment in the CSU patient group and control group. Materials and Methods: 146 patients who applied to Manisa Celal Bayar University Dermatology and Venereal Diseases outpatient clinic, with a diagnosis of chronic spontaneous urticaria, using antihistamine or omalizumab were included in the study. Results: The neutrophil and NLR values of the antihistamine and omalizumab treatment group with CSU diagnosis were found to be significantly higher than the pre-treatment control group, but there was no significant difference between each other. Platelet count was found higher and MPV value was found lower in omalizumab group compare to control group. In the omalizumab group, a significant decrease in neutrophil count and platelet count was measured at 3rd months. Conclusion: Neutrophil count, platelet count, NLR values were higher and MPV values were found to be low compared to the control group, these values can be used to measure disease activity. After the treatment, a significant decrease in neutrophil count and platelet count was detected in the omalizumab group. In addition to its anti-IgE effect, omalizumab can show its anti-inflammatory effect by reducing the neutrophil count and platelet count to be within the normal range.

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

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