scholarly journals Identification of vaccine candidate proteins in Ureaplasma urealyticum causing infertility

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
ShilpaJeevappa Shiragannavar ◽  
ShivakumarB Madagi
Keyword(s):  
Vaccine Candidate ◽  
Ureaplasma Urealyticum

scholarly journals DnaJ, A Promising Vaccine Candidate Against Ureaplasma Urealyticum Infection

2021 ◽  
Author(s):  
Fangyi Guo ◽  
Yanhong Tang ◽  
Wenjun Zhang ◽  
Hongxia Yuan ◽  
Jing Xiang ◽  
...  
Keyword(s):  
Cellular Response ◽  
Vaccine Candidate ◽  
Ureaplasma Urealyticum ◽  
Multidrug Resistant ◽  
Medical Intervention ◽  
Resistant Bacteria ◽  
Mouse Bone Marrow ◽  
Sexually Transmitted ◽  
Rapid Emergence ◽  
Promising Vaccine Candidate

Abstract Background: Ureaplasma urealyticum (Uu) is an important sexually transmitted pathogen that is responsible for diseases such as non-gonococcal urethritis, chorioamnionitis and neonatal respiratory diseases. The rapid emergence of multidrug-resistant bacteria threatens the effective treatment of U. urealyticum infections. Considering this, vaccination could be an efficacious medical intervention to prevent U. urealyticum infection and disease. As a highly conserved molecular chaperone, DnaJ is expressed and upregulated by pathogens soon after infection. Here, we assessed the potential of recombinant DnaJ vaccine in a mouse model and dendritic cells (DCs). Results: The results showed that intramuscular administration of recombinant DnaJ induced robust humoral- and T helper (Th) 1 cell-mediated immune responses and protected against cervical infection, inflammation, and the pathologic sequelae after U. urealyticum infection. Importantly, DnaJ also induced the maturation of mouse bone marrow-derived DCs (BMDCs), ultimately promoting naïve T-cell differentiation towards the Th1 phenotype. In addition, adoptive immunisation of DnaJ-pulsed BMDCs elicited antigen-specific immunoglobulin G2 antibodies as well as a Th1-biased cellular response in mice. Conclusion: We concluded that DnaJ can be a promising vaccine candidate to control U. urealyticum infections.

Antibiotische Therapie bei Ureaplasma-Urealyticum Kolonisation

2009 ◽  
Vol 213 (S 01) ◽  
Author(s):  
AW Flemmer ◽  
S Schubert ◽  
A Kramer ◽  
K Förster ◽  
A Schulze
Keyword(s):  
Ureaplasma Urealyticum ◽  
Antibiotische Therapie

Dengue and Zika Virus Infections Are Enhanced by Live Attenuated Dengue Vaccine but Not by Recombinant DSV4 Vaccine Candidate in Mouse Models

2020 ◽  
Author(s):  
Rahul Shukla ◽  
Julia A. Brown ◽  
Hemalatha Beesetti ◽  
Richa Ahuja ◽  
Viswanathan Ramasamy ◽  
...  
Keyword(s):  
Mouse Models ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Virus Infections ◽  
Dengue Vaccine

Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene.

1997 ◽  
Vol 71 (8) ◽  
pp. 6267-6270 ◽  
Author(s):  
R L Ward ◽  
B B Mason ◽  
D I Bernstein ◽  
D S Sander ◽  
V E Smith ◽  
...  
Keyword(s):  
Protein Gene ◽  
Vaccine Candidate ◽  
Rotavirus Vaccine ◽  
Human Rotavirus ◽  
Nsp4 Protein
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