25 Hydroxyvitamin D levels, quality of life, and disability in long-standing patients of somatization

Background: Vitamin D deficiency has been associated with cardiovascular mortality and sudden cardiac death in heart failure patients. Vitamin D may influence parathyroid hormone, the renin-angiotensin axis, natriuretic peptide gene expression, cardiac contractility, and cardiopulmonary function. Heart Failure (HF) studies using vitamin D to date have typically not used adequate repletion doses. Objectives: The primary objectives of this research were to determine if vitamin D repletion over a six month period in New York Heart Association (NYHA) Class II-III HF patients would result in a change in neurohormonal markers, cardiopulmonary exercise parameters, circulating 25- hydroxyvitamin D, and quality of life. Methods: A randomized, double-blinded, placebo-controlled trial assessing adjunctive Vitamin D3 supplementation in the treatment of NYHA Class II-III HF patients was conducted. Patients received 10,000 International Units (IU) per day of vitamin D3 or placebo for 6 months. Inclusion Criteria: 1) 25-hydroxyvitamin D level ≤32 ng/ml 2) stable medical regimen for 3 months. Exclusion Criteria: 1) any clinically unstable medical disorder 2) supplementation of vitamin D3 or D2 of greater than or equal to 2,000 IU/day. Study endpoints were: 1) B-type Natriuretic Peptide (BNP), 2) cardiopulmonary exercise parameters using Shape HF, 3) 25-hydroxyvitamin D, 4) intact parathyroid hormone (PTH), and 5) quality of life with the Kansas City Cardiomyopathy Questionnaire (KCCQ). Statistical analysis included independent samples t-test and multivariate regression. Results: A total of 34 patients completed the study. When adjusted for baseline 25-hydroxyvitamin D, the difference between groups for BNP was significant ([[Unable to Display Character: ∆]]540 ±1928 pg/ml placebo vs [[Unable to Display Character: ∆]] 35 pg/ml ±1054 pg/ml treatment p=0.009). 25-hydroxyvitamin D was [[Unable to Display Character: ∆]]48.9 ±32 ng/ml treatment vs [[Unable to Display Character: ∆]]3.6 ± 9.4 ng/ml placebo, p<0.001 (mean 68 ng/ml treatment vs 23 ng/ml placebo). No toxicity was observed with treatment. PTH and exercise chronotropic response index trended towards improvement in the treatment group vs placebo group, respectively (([[Unable to Display Character: ∆]]-20 ±20 pg/ml vs [[Unable to Display Character: ∆]]7 ±54pg/ml (p=0.06)) and ([[Unable to Display Character: ∆]]0.13±0.26 versus [[Unable to Display Character: ∆]]-0.03 ± 0.23, p=0.12)). KCCQ quality of life total symptom ([[Unable to Display Character: ∆]]16 ±16 treatment vs [[Unable to Display Character: ∆]]-12 ±15 placebo, p< 0.001) and individual scores significantly improved from baseline in the treatment group. Conclusions: Preliminary results show that vitamin D3 treatment of 10,000 IU/day in heart failure patients is safe, results in adequate circulating 25-hydroxyvitamin D levels, and achieves improvement in surrogate endpoint markers of HF outcomes.

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MP612SELF-REPORTED PHYSICAL ACTIVITY, QUALITY OF LIFE, AND PSYCHOLOGICAL STATUS IN RELATION TO PLASMA 25-HYDROXYVITAMIN D CONCENTRATION IN PREVALENT HEMODIALYSIS PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfw198.29 ◽

2016 ◽

Vol 31 (suppl_1) ◽

pp. i545-i545

Author(s):

Alicja E. Grzegorzewska ◽

Agnieszka Izdebska ◽

Leszek Niepolski ◽

Wojciech Warchoł ◽

Paweł P. Jagodziński

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Hemodialysis Patients ◽

Psychological Status ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Associations of 25-hydroxyvitamin D concentrations with quality of life and self-rated health

Bone Abstracts ◽

10.1530/boneabs.1.pp305 ◽

2013 ◽

Author(s):

Rachida Rafiq ◽

Karin Swart ◽

Schoor Natasja van ◽

Dorly Deeg ◽

Paul Lips ◽

...

Keyword(s):

Quality Of Life ◽

Hydroxyvitamin D ◽

Self Rated Health ◽

25 Hydroxyvitamin D

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Serum 25-Hydroxyvitamin D Level as an Independent Determinant of Quality of Life in Osteoporosis With a High Risk for Fracture

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.12.007 ◽

2014 ◽

Vol 36 (2) ◽

pp. 225-235 ◽

Cited By ~ 18

Author(s):

Hiroaki Ohta ◽

Yukari Uemura ◽

Toshitaka Nakamura ◽

Masao Fukunaga ◽

Yasuo Ohashi ◽

...

Keyword(s):

Quality Of Life ◽

High Risk ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Independent Determinant

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Abstract P1-09-27: High serum levels of 25-hydroxyvitamin D are associated with better quality-of-life, and lower levels of perceived stress, depression, and fatigue among breast cancer survivors

10.1158/1538-7445.sabcs14-p1-09-27 ◽

2015 ◽

Cited By ~ 1

Author(s):

Chi-Chen Hong ◽

Song Yao ◽

Yali Zhang ◽

Shicha Kumar ◽

Christine Ambrosone

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Survivors ◽

Perceived Stress ◽

Breast Cancer Survivors ◽

Serum Levels ◽

High Serum ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Associations of Serum 25-Hydroxyvitamin D Concentrations With Quality of Life and Self-Rated Health in an Older Population

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-4431 ◽

2014 ◽

Vol 99 (9) ◽

pp. 3136-3143 ◽

Cited By ~ 17

Author(s):

R. Rafiq ◽

K. M. A. Swart ◽

N. M. van Schoor ◽

D. J. Deeg ◽

P. Lips ◽

...

Keyword(s):

Quality Of Life ◽

Older Population ◽

Hydroxyvitamin D ◽

Self Rated Health ◽

25 Hydroxyvitamin D

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Quality Assessment of 25(OH)D, Insulin, Total Cholesterol, Triglycerides, and Potassium in 40-Year-Old Frozen Serum

Epidemiology Research International ◽

10.1155/2015/581206 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Monica Leu ◽

Kirsten Mehlig ◽

Monica Hunsberger ◽

Åsa Torinsson Naluai ◽

Kaj Blennow ◽

...

Keyword(s):

Quality Assessment ◽

Total Cholesterol ◽

Epidemiological Studies ◽

Fresh Blood ◽

Serum Samples ◽

Future Studies ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Absolute Agreement

Background. Many longitudinal epidemiological studies collect specimens into biobanks to investigate how biomarkers predict future disease. In 1968-1969, the Population Study of Women in Gothenburg (PSWG) established a biobank of serum samples. Objective. To examine the validity of 25-hydroxyvitamin D (25(OH)D), total cholesterol, triglycerides, insulin, and potassium after 40 years of storage at −20°C in terms of relative and absolute agreement. The quality of these markers under such condition has not been previously investigated. Methods. Baseline and remeasured levels were compared in selected samples through percentage change, correlation, and regression. 25(OH)D levels, not assessed at baseline, were compared by season, by BMI, and longitudinally over six years. Results. Despite some lack of absolute agreement, Spearman correlations were >0.7 and statistically significant for all biomarkers. The 1968-1969 25(OH)D correlated with BMI (r=-0.45, P=0.05) and with levels six years later (r=0.85, P<0.001). Summer 25(OH)D was higher than winter 25(OH)D (P=0.02). Conclusion. For all markers, baseline and remeasured levels exhibited high relative agreement. 25(OH)D was comparable with expected levels on fresh blood and varied with season. In future studies, PSWG individuals will be ranked according to these markers in order to predict incidence of disease.

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ROLE OF DIFFERENT HORMONES IN THE PATHOGENESIS AND SEVERITY OF ADOLESCENT IDIOPATHIC SCOLIOSIS

Acta Ortopédica Brasileira ◽

10.1590/1413-785220172501168600 ◽

2017 ◽

Vol 25 (1) ◽

pp. 15-17 ◽

Cited By ~ 4

Author(s):

RICARDO TEIXEIRA E SILVA ◽

RENAN JOSE RODRIGUES FERNANDES ◽

ALLAN HIROSHI DE ARAÚJO ONO ◽

RAPHAEL MARTUS MARCON ◽

ALEXANDRE FOGAÇA CRISTANTE ◽

...

Keyword(s):

Quality Of Life ◽

Adolescent Idiopathic Scoliosis ◽

Idiopathic Scoliosis ◽

Cobb Angle ◽

Inverse Correlation ◽

Serum Levels ◽

Diagnostic Study ◽

Level Of Evidence ◽

Hydroxyvitamin D

ABSTRACT Objective: To evaluate the hormonal profile of patients with adolescent idiopathic scoliosis (AIS) and its relationship to the severity of the curvature and quality of life . Method: Patients with scoliosis (Cobb angle above 10°), of both genders, diagnosed after 10 years of age were included, excluding those who presented other condition that could lead to scoliosis. Serum levels of 25-hydroxyvitamin D (25-OHD), cortisol and gastrin were correlated with Cobb angle and quality of life, measured by the SRS-30 questionnaire . Results: The levels of 25-OHD decreased in 97% of patients. There was an inverse relationship between gastrin levels and quality of life (p = 0.016). Moreover, there was an inverse correlation between the value of Cobb angle and quality of life (p = 0.036). There were no changes in cortisol levels. There was no correlation between Cobb angle and any of the hormones measured . Conclusion: The patients had levels of 25-OHD diminished, strengthening the hypothesis of its involvement in the development of AIS. This study also suggests that increased gastrin levels may be associated with a worse quality of life in patients with AIS. Level of Evidence II, Diagnostic Study.

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