Associations of 25-hydroxyvitamin D concentrations with quality of life and self-rated health

Background: Vitamin D deficiency has been associated with cardiovascular mortality and sudden cardiac death in heart failure patients. Vitamin D may influence parathyroid hormone, the renin-angiotensin axis, natriuretic peptide gene expression, cardiac contractility, and cardiopulmonary function. Heart Failure (HF) studies using vitamin D to date have typically not used adequate repletion doses. Objectives: The primary objectives of this research were to determine if vitamin D repletion over a six month period in New York Heart Association (NYHA) Class II-III HF patients would result in a change in neurohormonal markers, cardiopulmonary exercise parameters, circulating 25- hydroxyvitamin D, and quality of life. Methods: A randomized, double-blinded, placebo-controlled trial assessing adjunctive Vitamin D3 supplementation in the treatment of NYHA Class II-III HF patients was conducted. Patients received 10,000 International Units (IU) per day of vitamin D3 or placebo for 6 months. Inclusion Criteria: 1) 25-hydroxyvitamin D level ≤32 ng/ml 2) stable medical regimen for 3 months. Exclusion Criteria: 1) any clinically unstable medical disorder 2) supplementation of vitamin D3 or D2 of greater than or equal to 2,000 IU/day. Study endpoints were: 1) B-type Natriuretic Peptide (BNP), 2) cardiopulmonary exercise parameters using Shape HF, 3) 25-hydroxyvitamin D, 4) intact parathyroid hormone (PTH), and 5) quality of life with the Kansas City Cardiomyopathy Questionnaire (KCCQ). Statistical analysis included independent samples t-test and multivariate regression. Results: A total of 34 patients completed the study. When adjusted for baseline 25-hydroxyvitamin D, the difference between groups for BNP was significant ([[Unable to Display Character: ∆]]540 ±1928 pg/ml placebo vs [[Unable to Display Character: ∆]] 35 pg/ml ±1054 pg/ml treatment p=0.009). 25-hydroxyvitamin D was [[Unable to Display Character: ∆]]48.9 ±32 ng/ml treatment vs [[Unable to Display Character: ∆]]3.6 ± 9.4 ng/ml placebo, p<0.001 (mean 68 ng/ml treatment vs 23 ng/ml placebo). No toxicity was observed with treatment. PTH and exercise chronotropic response index trended towards improvement in the treatment group vs placebo group, respectively (([[Unable to Display Character: ∆]]-20 ±20 pg/ml vs [[Unable to Display Character: ∆]]7 ±54pg/ml (p=0.06)) and ([[Unable to Display Character: ∆]]0.13±0.26 versus [[Unable to Display Character: ∆]]-0.03 ± 0.23, p=0.12)). KCCQ quality of life total symptom ([[Unable to Display Character: ∆]]16 ±16 treatment vs [[Unable to Display Character: ∆]]-12 ±15 placebo, p< 0.001) and individual scores significantly improved from baseline in the treatment group. Conclusions: Preliminary results show that vitamin D3 treatment of 10,000 IU/day in heart failure patients is safe, results in adequate circulating 25-hydroxyvitamin D levels, and achieves improvement in surrogate endpoint markers of HF outcomes.

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MP612SELF-REPORTED PHYSICAL ACTIVITY, QUALITY OF LIFE, AND PSYCHOLOGICAL STATUS IN RELATION TO PLASMA 25-HYDROXYVITAMIN D CONCENTRATION IN PREVALENT HEMODIALYSIS PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfw198.29 ◽

2016 ◽

Vol 31 (suppl_1) ◽

pp. i545-i545

Author(s):

Alicja E. Grzegorzewska ◽

Agnieszka Izdebska ◽

Leszek Niepolski ◽

Wojciech Warchoł ◽

Paweł P. Jagodziński

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Hemodialysis Patients ◽

Psychological Status ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Serum 25-Hydroxyvitamin D Level as an Independent Determinant of Quality of Life in Osteoporosis With a High Risk for Fracture

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.12.007 ◽

2014 ◽

Vol 36 (2) ◽

pp. 225-235 ◽

Cited By ~ 18

Author(s):

Hiroaki Ohta ◽

Yukari Uemura ◽

Toshitaka Nakamura ◽

Masao Fukunaga ◽

Yasuo Ohashi ◽

...

Keyword(s):

Quality Of Life ◽

High Risk ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Independent Determinant

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25 Hydroxyvitamin D levels, quality of life, and disability in long-standing patients of somatization

Industrial Psychiatry Journal ◽

10.4103/ipj.ipj_73_17 ◽

2018 ◽

Vol 27 (1) ◽

pp. 87

Author(s):

Shruti Srivastava ◽

ManjeetSingh Bhatia ◽

Priyanka Gautam

Keyword(s):

Quality Of Life ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Abstract P1-09-27: High serum levels of 25-hydroxyvitamin D are associated with better quality-of-life, and lower levels of perceived stress, depression, and fatigue among breast cancer survivors

10.1158/1538-7445.sabcs14-p1-09-27 ◽

2015 ◽

Cited By ~ 1

Author(s):

Chi-Chen Hong ◽

Song Yao ◽

Yali Zhang ◽

Shicha Kumar ◽

Christine Ambrosone

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Survivors ◽

Perceived Stress ◽

Breast Cancer Survivors ◽

Serum Levels ◽

High Serum ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Quality of Life and Associated Factors in Young Workers

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18042153 ◽

2021 ◽

Vol 18 (4) ◽

pp. 2153

Author(s):

José Andrade Louzado ◽

Matheus Lopes Cortes ◽

Márcio Galvão Oliveira ◽

Vanessa Moraes Bezerra ◽

Sóstenes Mistro ◽

...

Keyword(s):

Quality Of Life ◽

Odds Ratio ◽

Cross Sectional Study ◽

Young Workers ◽

Cross Sectional ◽

Physically Active ◽

Significance Level ◽

Self Rated Health ◽

Assess Quality

Background: This study aimed to identify the factors associated with the quality of life of young workers of a Social Work of Industry Unit. Methods: This was a cross-sectional study conducted on 1270 workers. Data were collected using a digital questionnaire built on the KoBoToolbox platform that included the EUROHIS-QOL eight-item index to assess quality of life. Demographic, socioeconomic, behavioral, and clinical variables were considered explanatory. The associations were analyzed using the ordinal logistic regression model at a 5% significance level. Results: Men and women had a mean quality of life of 31.1 and 29.4, respectively. Workers that rated their health as “very good” had an odds ratio of 7.4 (95% confidence interval (CI) = 5.17–10.81), and those who rated it as “good” had an odds ratio of 2.9 (95% CI = 2.31–3.77). Both these groups of workers were more likely to have higher levels of quality of life as compared to workers with “regular”, “poor”, or “very poor” self-rated health. Physically active individuals were 30% more likely to have higher levels of quality of life (odds ratio = 1.3; 95% CI = 1.08–1.65). After adjusting the model by gender, age group, marital status, socioeconomic class, self-rated health, nutritional status, and risky alcohol consumption, the odds ratio of active individuals remained stable (odds ratio = 1.3; 95% CI = 1.05–1.66). Conclusions: In the present study, self-rated health, physical activity, and gender were associated with young workers’ quality of life.

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Health-related quality of life in tension-type headache: a population-based study

Scandinavian Journal of Pain ◽

10.1515/sjpain-2020-0166 ◽

2021 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Sait Ashina ◽

Dawn C. Buse ◽

Jakob B. Bjorner ◽

Lars Bendtsen ◽

Ann C. Lyngberg ◽

...

Keyword(s):

Quality Of Life ◽

Episodic Migraine ◽

Tension Type Headache ◽

Eysenck Personality Questionnaire ◽

Health Related Quality ◽

Self Rated Health ◽

Related Quality ◽

Health Related ◽

Type Headache

Abstract Objectives Tension-type headache (TTH) is the most prevalent primary headache disorder. We assessed the cross-sectional impact of TTH on health related quality of life (HRQoL) in a general population. We also examined the association of HRQoL scores with headache frequency, disability, medication overuse, poor self-rated health, psychiatric comorbidity, and pain sensitivity in individuals with TTH. Methods A sample of 547 subjects completed a headache diagnostic interview, the SF-12 to calculate physical (PCS) and mental (MCS) health component scores, depression (major depression inventory [MDI]) and neuroticism (Eysenck Personality Questionnaire) measures. We defined the following headache diagnosis categories: pure TTH, pure migraine, and coexistent headache (TTH + migraine). Cases were further classified into chronic (≥15) or episodic (<15 headache days/month). Results Using generalized linear models (GLM) adjusted for age, sex and education, both PCS-12 and MCS-12 scores varied in groups distinguished by migraine and TTH status; scores were lower for individuals with coexistent headache (TTH + migraine; n=83), followed by pure TTH (n=97) and pure migraine (n=43) compared to the no headache group (n=324) (p≤0.001). In analyses considering chronicity, PCS-12 scores were lower in chronic coexistent headache followed by pure chronic TTH (CTTH), episodic migraine +/− episodic TTH (ETTH) and pure ETTH than in the no headache group (p≤0.001). MCS-12 scores were lower in pure CTTH, followed by chronic coexistent headache, episodic migraine +/− ETTH and pure ETTH compared to the no headache group (p≤0.001). Multiple regression models showed that in TTH, lower PCS-12 scores were associated with age (p=0.04), female sex (p=0.02), and poor self-rated health (p≤0.001). Lower MCS-12 scores in TTH were associated with depression (p≤0.001). Conclusions In a population sample, TTH, and to higher degree CTTH, are associated with decreased HRQoL.

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