Evaluation of Ischemia-Modified Albumin and Fibrinogen in Relation with High-Sensitive C-reactive Protein in Diabetic Foot Ulcers

Diabetes mellitus is a metabolic disorder that experiences hyperglycemia and causes various complications, including diabetic foot ulcers (DFU). Hyperglycemia can cause chronic inflammation and decreased function of immune cells. This study aims to determine the correlation between blood profiles and serum C-Reactive Protein (CRP) in diabetes mellitus patients with diabetic ulcers. A total of 30 blood samples of diabetes mellitus patients with blood tests and serum CRP. Blood profile examination used an automatic method with a hematology analyzer, erythrocyte sedimentation rate (ESR) using the Westergreen method, and serum CRP using a semi-quantitative method. In the correlation regression multiple test knowed that the parameters associated with CRP serum are hemoglobin (r = 23.553; p = 0.015), hematocrit (r = -8.678; p = 0.016), leukocyte count (r = 2.098; p = 0.004), and platelet count (r = -0.112; p = 0.002) because it has significance (p < 0.05). Meanwhile, the parameters of erythrocyte count (r = -8.717; p = 0.359), and ESR (r = -0.142; p = 0.109) had no effect on serum CRP levels because they had significance (p> 0.05). The conclusion of this study shows there is a strong correlation (r = 0.777) between blood profile and serum CRP in diabetes mellitus patients with diabetic foot ulcers.

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Serum procalcitonin and C-reactive protein concentrations to distinguish mildly infected from non-infected diabetic foot ulcers: a pilot study

Diabetologia ◽

10.1007/s00125-007-0840-8 ◽

2007 ◽

Vol 51 (2) ◽

pp. 347-352 ◽

Cited By ~ 82

Author(s):

A. Jeandrot ◽

J.-L. Richard ◽

C. Combescure ◽

N. Jourdan ◽

S. Finge ◽

...

Keyword(s):

Pilot Study ◽

Diabetic Foot ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

C Reactive Protein ◽

Reactive Protein

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Is Ischemia-Modified Albumin a Biomarker in Wagner Classification in Diabetic Foot Ulcers?

10.22541/au.162430815.56999774/v1 ◽

2021 ◽

Author(s):

Sezai ÖZKAN ◽

cihan ADANAS ◽

hamit hakan alp

Keyword(s):

Diabetic Foot ◽

Predictive Value ◽

Cross Sectional Study ◽

Foot Ulcers ◽

Control Group ◽

Diabetic Foot Ulcers ◽

Cross Sectional ◽

Ischemia Modified Albumin ◽

Reactive Protein ◽

Similar Body

Background: We aimed to determine the relationship of ischemia-modified albumin (IMA) with diabetic foot ulcers and its predictive value in the Wagner classification. Methods: Our cross-sectional study was conducted in 120 diabetic foot patients and 60 healthy individuals with similar body mass index and age. Patients with a diabetic foot were classified according to the Wagner classification. Biochemical parameters, C-reactive protein (CRP) and IMA levels were measured in all patients and healthy volunteers. Screening performance characteristics of CRP and IMA were calculated according to Wagner classes and the presence of osteomyelitis. Results: CRP and IMA levels in the patient group were significantly higher than the control group. The highest IMA levels were detected in Wagner grade 5. CRP had higher sensitivity and specificity than IMA in the discrimination of other grades, except for grade 4-5 separation. For Wagner grade 4-5 distinction, IMA had 84.6% sensitivity and 94.7% specificity. Conclusion: IMA may play a role in the pathogenesis of diabetic foot ulcers and had a higher predictive value in discrimination of the Wagner grade 4 and 5. In the management of diabetic foot patients, it may be recommended that IMA is evaluated by clinicians.

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High Serum Concentration of Interleukin-18 in Diabetic Patients with Foot Ulcers

Journal of the American Podiatric Medical Association ◽

10.7547/0003-0538-104.3.222 ◽

2014 ◽

Vol 104 (3) ◽

pp. 222-226 ◽

Cited By ~ 4

Author(s):

Tevfik Sabuncu ◽

Mehmet Ali Eren ◽

Suzan Tabur ◽

Omer Faruk Dag ◽

Omer Boduroglu

Keyword(s):

Diabetic Foot ◽

High Sensitivity ◽

High Serum ◽

Foot Ulcers ◽

Diabetic Patients ◽

Diabetic Foot Ulcers ◽

Interleukin 18 ◽

Reactive Protein ◽

History Of

Background It is well known that interleukin-18 (IL-18) plays a key role in the inflammatory process. However, there are limited data on the role IL-18 plays with diabetic foot ulcers, an acute and complex inflammatory situation. Therefore, we aimed to evaluate serum IL-18 levels of diabetic patients with foot ulcers. Methods Twenty diabetic patients with acute foot ulcers, 21 diabetic patients without a history of foot ulcers, and 21 healthy volunteers were enrolled in our study. Circulating levels of IL-18, and other biochemical markers are parameters of inflammation and were measured in all three groups. Results Diabetic patients both with and without foot ulcers had high IL-18 concentrations (P < 0.001 and P = 0.020, respectively) when compared with the nondiabetic volunteers. Those with foot ulcers had higher levels of IL-18 level (P < 0.001), high-sensitivity C-reactive protein (hsCRP) (P = 0.001), and erythrocyte sedimentation rate (ESR) (P < 0.001) than those without foot ulcers. Conclusions We found that serum IL-18 concentrations were elevated in diabetic patients with acute diabetic foot ulcers. However, these findings do not indicate whether the IL-18 elevation is a cause or a result of the diabetic foot ulceration. Further studies are needed to show the role of IL-18 in the course of these ulcers.

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