Comparative therapeutic response of instant and incremental oleation (Sadya and Aarohi Snehapana) over hematological and biochemical parameters in healthy volunteers: A pilot study

2019 ◽  
Vol 7 (3) ◽  
pp. 151
Author(s):  
GauravR Sawarkar ◽  
PunamG Sawarkar
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Biochemical Parameters ◽  
Therapeutic Response ◽  
Hematological And Biochemical Parameters

scholarly journals Evaluation of safety of Arohi Snehapana (Incremental Oleation Therapy) Over Physical, Hematological and Biochemical Parameters in Healthy Volunteers

2021 ◽  
pp. 112-120
Author(s):  
Punam Sawarkar ◽  
Vaishali Kuchewar ◽  
Gaurav Sawarkar
Keyword(s):  
Healthy Volunteers ◽  
Biochemical Parameters ◽  
Systemic Circulation ◽  
Protective Role ◽  
P Value ◽  
Hematological And Biochemical Parameters ◽  
Sample Method ◽  
Purposive Sample ◽  
Specific Lipid

Background: Ayurveda strongly recommends the Panchakarma (Purification or detoxification therapies), e.g., Vamana (Therapeutic emesis) & Virechana (Therapeutic purgation) etc., in healthy persons for the prevention of the diseases & maintenance of the health. Vamana & Virechana are preceded by the Arohi Snehapana (Incremental oleation) compromising of intake of specific lipid in a large quantity. As it facilitates the smooth conduction of these procedures & brings bio-toxins in the systemic circulation for their easy elimination through these procedures;therefore it is the mandatory criteria before these procedures. However, there is apprehension about its lipid elevating effect; therefore, there is quite a restriction in its acceptability in the current cholesterol-sensitive era. Ultimately, people hesitate to undergo Shodhana measures & they get deprived of their miraculous results. Aim and Objective: Considering these hurdles, the current study was planned to evaluate and assess the safety effects of Arohi Snehapana over physical, hematological, and biochemical parameters in healthy volunteers. Materials and Methods: This is a single-centric, open-labeled clinical trial in which a total of 50 healthy volunteers (both male & female) were recruited. All volunteers were selected by purposive sample method & were prescribed Incremental oleation with cow ghee before Shodhana therapy for a maximum of 7 days or till achievement of proper oleation features, whichever is earlier. All volunteers were assessed for physical (weight, B.M.I.), hematological & biochemical parameters before & just after the intervention. Result and Observations: In this study, Bodyweight declined significantly by 3-4 kg (1.47%. ) for (P<0.001) within 1-7 days of an intervention despite using a good amount of fat (Go-Ghrita). Blood urea was significantly decreased by 12.63 % (for p-Value <0.001), but this decrease was absolutely within the normal range. Significant reduction in blood urea after invention proves the role of Snehapana to reduce overload over the kidney and perform the protective role. No significant elevation in lipid profile due to this intervention. Conclusion: The current study evaluates the efficacy of Incremental oleation with respect to various proper oleation features and its safety over physical, hematological, and biochemical parameters in healthy volunteers.

Influence of increased doses of fenbendazole supramolecular complex on sheep’s organism

2018 ◽  
Vol 12 (2) ◽  
pp. 46-52 ◽  
Author(s):  
A.I. Varlamova
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Biochemical Parameters ◽  
Negative Influence ◽  
Supramolecular Complex ◽  
Control Group ◽  
Blood Cell Count ◽  
Russian Scientific ◽  
Russian Scientific Research Institute ◽  
Hematological And Biochemical Parameters

The purpose of the research: study of the influence of increased doses of fenbendazole supramolecular complex (FSMC) on sheep’s organism. Materials and methods. The experiment was carried out at the Podolsk Department of All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin on 20 manorial invasion-free sheep aged 2-3 years old. Animals were divided according to the principle of analogues into 4 groups, 5 heads in each group. Animals of the 1, 2 and 3 group were orally administered with FSMC given as a single dose of 2, 6, 10 mg/kg, respectively, according to the active substance, i.e in therapeutic and in a dose increased by 3 and 5 times. Sheep of the fourth group didn’t receive the drug and they were as control. Study of clinical, hematological and biochemical parameters of animals from all groups was conducted 1 day before and in 1, 3, 5 days after administration of the drug by means of standard methods. Results and discussion. FSMC in therapeutic dose as well as in a dose increased by 3 and 5 times doesn’t have negative influence on clinical, hematological and biochemical parameters of the sheep. State of the sheep, which received the drug in doses of 20, 60, 100 mg/kg, was within the physiologically normal state and didn’t differ from the state before administration of the drug and from the animals of the control group. Drug security index exceeds 5. Red blood cell count, white blood cell count, hemoglobin count, leukogram parameters as well as biochemical parameters of blood: activity of alkaline phosphatase and amylase, bilirubin, creatinine, urea and glucose counts were within normal limits and didn’t differ from the parameters of the control animals.

Effect of Age and Performance on Physical, Hematological, and Biochemical Parameters in Endurance Horses

2013 ◽  
Vol 33 (6) ◽  
pp. 415-420 ◽  
Author(s):  
Lawan Adamu ◽  
Mohd Adzahan Noraniza ◽  
Abdullah Rasedee ◽  
Ahmad Bashir
Keyword(s):  
Biochemical Parameters ◽  
Hematological And Biochemical Parameters ◽  
And Performance ◽  
Effect Of Age

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

2015 ◽  
Vol 149 ◽  
pp. 39-46 ◽  
Author(s):  
Guilherme M. Do Carmo ◽  
Matheus D. Baldissera ◽  
Rodrigo A. Vaucher ◽  
Virginia Cielo Rech ◽  
Camila B. Oliveira ◽  
...  
Keyword(s):  
Essential Oil ◽  
Biochemical Parameters ◽  
Trypanosoma Evansi ◽  
Diminazene Aceturate ◽  
Hematological And Biochemical Parameters ◽  
Achyrocline Satureioides

scholarly journals Exploring alterations in hematological and biochemical parameters, enzyme activities and serum cortisol in Besnoitia besnoiti naturally infected dairy cattle

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Luca Villa ◽  
Alessia Libera Gazzonis ◽  
Sergio Aurelio Zanzani ◽  
Silvia Mazzola ◽  
Alessia Giordano ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Biochemical Parameters ◽  
Statistical Significance ◽  
Clinical Signs ◽  
Serum Cortisol ◽  
Lower Percentage ◽  
Besnoitia Besnoiti ◽  
Laboratory Parameters ◽  
Bovine Besnoitiosis ◽  
Hematological And Biochemical Parameters

Abstract Background Besnoitia besnoiti is an Apicomplexan protozoa causative of bovine besnoitiosis, a chronic and debilitating disease of cattle, with a variety of pathological findings that could alter some laboratory parameters. A study was conducted in a bovine besnoitiosis endemically infected dairy herd located in Italy characterized by high intra-herd seroprevalence and cattle with clinical signs of the disease. In the study, alterations in laboratory parameters, i.e. hematological and biochemical parameters, enzyme activities and serum cortisol levels, in Besnoitia besnoiti naturally infected cows were investigated in depth. Methods Laboratory parameters in 107 cows, of which 61 were seronegative and 46 were seropositive to B. besnoiti, including 27 with clinical signs of bovine besnoitiosis, were compared. Generalized linear models were used to evaluate the effect of Besnoitia infection on the considered laboratory parameters. Results Hematological analyses revealed that B. besnoiti infection determined a significant alteration to the leukocyte differential, with a higher percentage of granulocytes and a lower percentage of lymphocytes in seropositive and clinically affected animals (Mann–Whitney U-test, P = 0.022); erythrocyte and platelet counts did not show any difference between the considered groups of cows. Biochemistry tests evidenced that the parasite infection influenced serum protein values in seropositive cows and glutamate dehydrogenase values in clinically affected animals. No or only slight differences were revealed for all of the other biochemical and enzyme activity parameters in B. besnoiti-infected animals. In addition, despite the lack of statistical significance, seropositive and clinically affected cows evidenced higher concentrations of serum cortisol values compared to seronegative animals. Conclusions Although physiological, pathological and farm-related factors could have influenced the results in investigated animals, further studies involving more animals from different farms would be advisable to infer the role of B. besnoiti on these alterations, since laboratory parameters could help veterinarians in the diagnosis of bovine besnoitiosis in cattle.

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