scholarly journals Organochlorine pesticide exposure as a risk factor for breast cancer in young Indian women: A case–control study

2019 ◽  
Vol 08 (04) ◽  
pp. 212-214 ◽  
Author(s):  
Navneet Kaur ◽  
Srikant K Swain ◽  
Basudev D Banerjee ◽  
Tusha Sharma ◽  
Thammineni Krishnalata
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Young Women ◽  
Case Control Study ◽  
Pesticide Exposure ◽  
Serum Levels ◽  
Case Control ◽  
Incidence Rates ◽  
Younger Women ◽  
Control Study

Abstract Background: Incidence rates of breast cancer are showing an increasing trend in young women (≤40 years) in India. Risk for breast cancer in this age group can be attributed only partially to various known risk factors. Environmental exposure to organochlorine (OC) compounds has been identified as a potential risk factor. However, the possible role of OC compounds in increasing breast cancer risk in young women has not been explored. This case–control study was planned with the objectives to assess the serum levels of OC compound in a North Indian population of young women. Materials and Methods: Forty-two patients of breast cancer ≤ 40 years age and 42 age-matched controls were evaluated for exposure to OC compounds by performing assays in blood samples for pesticides such as dichlorodiphenyltrichloroethane (DDT) and its metabolites DDD and DDE; dieldrin; aldrin; methoxychlor, heptachlor; α-endosulfan; β-endosulfan; and hexachlorocyclohexane and its isomers (α, β, and γ). Results: Young women with breast cancer were found to have significantly higher serum levels of all the OC compounds except aldrin, p, p’ DDT, and methoxychlor. Conclusions: Exposure to OC pesticides could be an important modifiable risk factor for breast cancer, especially in younger women.

scholarly journals Organochlorine Pesticides Exposure as a Risk Factor for Breast Cancer in Young Women: A Case Control Study

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 7s-7s
Author(s):  
S.K. Swain ◽  
N. Kaur ◽  
B.D. Banerjee ◽  
K. Thamineni ◽  
T. Sharma
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Young Women ◽  
Indian Population ◽  
Case Control Study ◽  
Organochlorine Compounds ◽  
Younger Women ◽  
Age Of Menarche ◽  
Control Study

Background: Young women (< 40 years) constitutes about 10%–25% of total breast cancer cases in south-Asian women and an increase in incidence rates have been noted in the recent past. It is higher compared with their western counterparts, where rates of 5%–10% are reported. Younger women usually present with more aggressive tumor and poorer prognosis, suggesting that breast cancer in young women represents a distinct entity. Exposure to environmental estrogens such as organochlorine compounds in pesticides and industrial chemical has been proposed to be a risk factor for breast cancer. There is rampant use of pesticides in farming in south-Asian countries. However the associations between organochlorine compounds and breast cancer risk, reported in different studies has been inconsistent. Hence this study was planned with the objectives to assess the serum levels of organochlorine compound and the presence of other risk factors in north Indian population of young women diagnosed with breast cancer. Aim: To assess the serum level of organochlorine compounds and the other risk factors in north-Indian population of young women diagnosed with breast cancer. Methods: This case control study was conducted at UCMS & GTB Hospital, Delhi, India in 42 patients of breast cancer ≤ 40 years age and 42 age-matched-controls. The study subjects were evaluated for various known risk factors such as family history of breast or ovarian cancer, age of menarche, number of pregnancies and abortions, duration of breast feeding, oral contraceptive intake, obesity, benign breast disease & biopsy, etc. Study subjects were also evaluated for exposure to environmental pollutants by performing of assays of twelve different organochloride pesticides in their blood samples. Genetic analysis also done to look for polymorphisms of genes: BRCA1 at Q365R, BRCA2 at 6174delT and p53 at 216 location. Results: Significant association was seen between serum level of β- HCH, heptachlor, dieldrin, p,p'-DDE and risk of breast cancer in young women in our patient population. Significant association was also found between early age of menarche, obesity, BRCA 2 and p53 gene polymorphism as risk factors for breast cancer. Conclusion: Exposure to organochlorine pesticides could be an important modifiable risk factor, responsible for an increase in the rates of breast cancer in younger women. Polymorphism of p53 at 216 location & BRCA2 at 6174delT could be independent susceptibility marker in younger women with breast cancer. Larger studies are required to validate these results.

A CASE-CONTROL STUDY ON HORMONE THERAPY AS A RISK FACTOR FOR BREAST CANCER IN FINLAND

Maturitas ◽  
2009 ◽  
Vol 63 ◽  
pp. S50 ◽  
Author(s):  
H. Lyytinen ◽  
T. Dyba ◽  
O. Ylikorkala ◽  
E. Pukkala
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Hormone Therapy ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Dietary fat and breast cancer in Saudi Arabia: a case-control study

2004 ◽  
Vol 10 (6) ◽  
pp. 879-886
Author(s):  
A. Al Othaimeen ◽  
A. Ezzat ◽  
G. Mohamed ◽  
T. Muammar ◽  
A. Al Madouj
Keyword(s):  
Breast Cancer ◽  
Dietary Fat ◽  
Case Control Study ◽  
Saturated Fat ◽  
Positive Association ◽  
Serum Levels ◽  
Case Control ◽  
Serum Triglycerides ◽  
Significant Positive Association ◽  
Control Study

A case-control study investigated the association between dietary fat and breast cancer in Saudi Arabian women attending a specialist hospital in Riyadh. Women with breast carcinoma [n= 499] newly diagnosed between 1996-2002, and control women [n = 498] randomly selected from patients’ attendants and relatives, completed a food frequency questionnaire. Serum levels of triglycerides and total cholesterol were measured. A significant positive association was found between risk of breast cancer and intake of fats, protein and calories. Adjusted odds ratios for the highest quartile of intake versus the lowest were 2.43 for saturated fat, 2.25 for animal protein, 2.12 for polyunsaturated fat, 1.88 for cholesterol and 2.69 for total energy from dietary intake. For serum triglycerides the adjusted odds ratio was 2.16 for the highest quartile

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