2003 ◽  
Vol 68 (1) ◽  
pp. 169-181 ◽  
Author(s):  
Bradley E. Ensor ◽  
Marisa O. Ensor ◽  
Gregory W. De Vries

Waters and Ravesloot (2001) test the assumption that natural river channel change caused periods of Hohokam cultural reorganization. However, they conclude that channel changes did not correlate with all periods and areas of significant cultural changes and that landscape alone cannot explain Hohokam transformations. An anthropological perspective on political ecology and disasters can explain why environmental processes and events differentially impact societies, differentially impact societies diachronically and differentially impact social groups within societies. We suggest that this perspective may explain the variability described by Waters and Ravesloot.


Author(s):  
J. Rose Wallick ◽  
Scott W. Anderson ◽  
Charles Cannon ◽  
Jim E. O'Connor

2020 ◽  
Vol 21 (7) ◽  
pp. 2458 ◽  
Author(s):  
Sven Kappel ◽  
Tatiana Kilch ◽  
Roland Baur ◽  
Martin Lochner ◽  
Christine Peinelt

Store-operated heteromeric Orai1/Orai3 channels have been discussed in the context of aging, cancer, and immune cell differentiation. In contrast to homomeric Orai1 channels, they exhibit a different pharmacology upon application of reactive oxygen species (ROS) or 2-aminoethoxydiphenyl borate (2-APB) in various cell types. In endogenous cells, subunit composition and arrangement may vary and cannot be defined precisely. In this study, we used patch-clamp electrophysiology to investigate the 2-APB profile of store-operated and store-independent homomeric Orai1 and heteromeric Orai1/Orai3 concatenated channels with defined subunit compositions. As has been shown previous, one or more Orai3 subunit(s) within the channel result(s) in decreased Ca2+ release activated Ca2+ current (ICRAC). Upon application of 50 µM 2-APB, channels with two or more Orai3 subunits exhibit large outward currents and can be activated by 2-APB independent from storedepletion and/or the presence of STIM1. The number and position of Orai3 subunits within the heteromeric store-operated channel change ion conductivity of 2-APB-activated outward current. Compared to homomeric Orai1 channels, one Orai3 subunit within the channel does not alter 2-APB pharmacology. None of the concatenated channel constructs were able to exactly simulate the complex 2-APB pharmacology observed in prostate cancer cells. However, 2-APB profiles of prostate cancer cells are similar to those of concatenated channels with Orai3 subunit(s). Considering the presented and previous results, this indicates that distinct subtypes of heteromeric SOCE channels may be selectively activated or blocked. In the future, targeting distinct heteromeric SOCE channel subtypes may be the key to tailored SOCE-based therapies.


2019 ◽  
Vol 579 ◽  
pp. 124209 ◽  
Author(s):  
Dangwei Wang ◽  
Yuanxu Ma ◽  
Xiaofang Liu ◽  
He Qing Huang ◽  
Li Huang ◽  
...  

Water ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1360 ◽  
Author(s):  
Alissa Flatley ◽  
Ian Rutherfurd ◽  
Ross Hardie

River relocation is the diversion of a river into an entirely new channel for part of their length (often called river diversions). Relocations have been common through history and have been carried out for a wide range of purposes, but most commonly to construct infrastructure and for mining. However, they have not been considered as a specific category of anthropogenic channel change. Relocated channels present a consistent set of physical and ecological challenges, often related to accelerated erosion and deposition. We present a new classification of river relocation, and present a series of case studies that highlight some of the key issues with river relocation construction and performance. Primary changes to the channel dimensions and materials, alongside changes to flow velocity or channel capacity, can lead to a consistent set of problems, and lead to further secondary and tertiary issues, such as heightened erosion or deposition, hanging tributaries, vegetation loss, water quality issues, and associated ecological impacts. Occasionally, relocated channels can suffer engineering failure, such as overtopping or complete channel collapse during floods. Older river relocation channels were constructed to minimise cost and carry large floods, and were straight and trapezoidal. In some countries, modern relocated channels represent an exciting new challenge in that they are now designed to replicate natural rivers, the success of which depends on understanding the characteristics, heterogeneity, and mechanisms at work within the natural channel. We discuss shortcomings in current practice for river relocation and highlight areas for future research for successful rehabilitation of relocated rivers.


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