scholarly journals Acute Visual Loss Induced by Dexamethasone during Neoadjuvant Docetaxol

2008 ◽  
Vol 2 ◽  
pp. CMO.S339
Author(s):  
D.L. Gregory ◽  
C.D. Jones ◽  
E.R.E. Denton ◽  
A.N. Harnett
Keyword(s):  
Breast Cancer ◽  
Visual Acuity ◽  
Neoadjuvant Chemotherapy ◽  
Visual Loss ◽  
Chemotherapy Regimen ◽  
Acute Onset ◽  
Second Line ◽  
Central Serous Retinopathy ◽  
Steroid Dose ◽  
Acute Visual Loss

We present a case of a female patient who developed acute onset of visual loss due to central serous retinopathy as a consequence of steroid premedication for docetaxol given as second line neoadjuvant chemotherapy for breast cancer. Central serous retinopathy is a recognised association with steroids but has not been previously reported in association with the management of solid tumours. Reduction in steroid dose and duration permitted recovery of her visual acuity while allowing completion of the prescribed chemotherapy regimen. An overview of the presentation, pathogenesis, aetiologies and management of central serous retinopathy is given.

scholarly journals Central serous retinopathy: an unusual cause of acute visual loss

CJEM ◽  
2013 ◽  
Vol 15 (05) ◽  
pp. 311-313
Author(s):  
Jennifer L. Chu ◽  
Jeffrey Tyberg
Keyword(s):  
Emergency Medicine ◽  
Visual Loss ◽  
Vision Loss ◽  
Temporal Arteritis ◽  
Typical Case ◽  
Central Serous Retinopathy ◽  
Functional Disorders ◽  
Emergency Physicians ◽  
Acute Visual Loss ◽  
Ed Visits

ABSTRACT Ophthalmologic complaints represent approximately 2% of emergency department (ED) visits. Acute vision loss is the most serious of such presentations and requires prompt assessment for a treatable cause. The differential diagnosis for acute vision loss includes retinal detachment, macular disorders, vaso-occlusive disorders, temporal arteritis, neuro-ophthalmologic disorders, and functional disorders. We report the case of a previously healthy 33-year-old man who presented to the ED with acute bilateral vision loss that was ultimately diagnosed as central serous retinopathy (CSR), an idiopathic, self-limited condition that typically affects males age 20 to 50 years. This condition is not mentioned in standard emergency medicine textbooks or the emergency medicine literature, and our hope is that our report will serve to illustrate a typical case of CSR and help prompt emergency physicians to consider this diagnosis in the appropriate circumstances.

From clinical trials to clinical practice: outcome of NSABP-B27 neoadjuvant chemotherapy regimen for high-risk early-stage breast cancer

2017 ◽  
Vol 165 (3) ◽  
pp. 771-777 ◽  
Author(s):  
Hikmat Abdel-Razeq ◽  
Lina Marei ◽  
Salwa S. Saadeh ◽  
Hazem Abdulelah ◽  
Mahmoud Abu-Nasser ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Clinical Practice ◽  
High Risk ◽  
Neoadjuvant Chemotherapy ◽  
Chemotherapy Regimen ◽  
Early Stage ◽  
Early Stage Breast Cancer

scholarly journals Acute retinal necrosis in a patient with remote severe herpes simplex encephalitis

2019 ◽  
Vol 12 (5) ◽  
pp. e229137 ◽  
Author(s):  
Takaaki Kobayashi ◽  
Poorani Sekar ◽  
Jeffery Meier ◽  
Judy Streit
Keyword(s):  
Herpes Simplex ◽  
Visual Loss ◽  
Acute Onset ◽  
Acute Retinal Necrosis ◽  
High Dose ◽  
Acute Visual Loss ◽  
Intravenous Acyclovir ◽  
Dose Oral ◽  
Simplex Virus ◽  
Hsv 1

A 60-year-old man with a history of severe herpes simplex virus type 1 (HSV-1) encephalitis 2 years prior presented with acute onset of visual loss in the left eye. Dilated funduscopic examination showed retinitis and occlusive vasculitis with retinal necrosis. PCR of the vitreous fluid was positive for HSV-1, and he was diagnosed with acute retinal necrosis (ARN) due to HSV-1. The patient was treated with intravenous acyclovir and intravitreous foscarnet for 2 weeks, followed by high dose oral valacyclovir for 2 weeks. He was subsequently placed on planned life-long suppressive valacyclovir. His case demonstrates that acute visual loss concomitant with or subsequent to HSV-1 encephalitis warrants suspicion of ARN. Prompt therapy with effective antiviral medication is necessary to reduce the risk of sight-threatening complications. Chronic suppression with oral antiviral therapy after ARN is recommended to prevent involvement of the contralateral eye, though there is no consensus on the duration and dosage of antivirals.

scholarly journals Paraneoplastic optic neuropathy secondary to adenocarcinoma of the lung

2021 ◽  
Vol 14 (5) ◽  
pp. e242082
Author(s):  
Jin Yi Yap ◽  
Wan-Hazabbah Wan HItam ◽  
Sanihah Abdul Halim ◽  
Nurul Ain Masnon
Keyword(s):  
Visual Acuity ◽  
Optic Neuropathy ◽  
Visual Loss ◽  
Hand Movement ◽  
Healthy Woman ◽  
Lung Mass ◽  
Adenocarcinoma Of The Lung ◽  
Acute Visual Loss ◽  
Lung Lobectomy ◽  
The Right

We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.

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