scholarly journals Squamous Differentiation and Cytokeratin Expression in an Osteosarcoma: A Case Report and Review of the Literature

2008 ◽  
Vol 1 ◽  
pp. CPath.S582 ◽  
Author(s):  
Lester J. Layfield ◽  
Lyska Emerson ◽  
Julia R. Crim ◽  
Lor Randall
Keyword(s):  
Case Report ◽  
Metastatic Disease ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Squamous Differentiation ◽  
Therapeutic Implications ◽  
Squamous Cells ◽  
Cytokeratin Expression ◽  
Synovial Sarcomas ◽  
Pearl Formation

Cytokeratin expression has been documented in a variety of sarcomas including synovial sarcomas, epithelioid sarcomas, Ewing's sarcomas and, rarely, osteosarcomas. In osteosarcomas immunohistochemically shown to expression cytokeratins, a component of epithelioid cells is generally present. These epithelioid cytokeratin positive cells raise the possibility of metastatic disease with prognostic and therapeutic implications differing from primary osteosarcoma. The cytokeratin-expressing cells of the cases reported in the literature have not shown definitive squamous differentiation with keratin pearl formation. We report a case of osteosarcoma in which islands of malignant squamous cells were present showing keratin pearl formation and expression of cytokeratins.

Squamous Differentiation in a Sarcomatoid Chromophobe Renal Cell Carcinoma: An Unusual Case Report With Review of the Literature

2008 ◽  
Vol 132 (10) ◽  
pp. 1672-1674
Author(s):  
Seethalakshmi Viswanathan ◽  
Sangeeta B. Desai ◽  
S. R. Prabhu ◽  
Mahul B. Amin
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Unusual Case ◽  
Chromophobe Renal Cell Carcinoma ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Squamous Differentiation ◽  
Unusual Case Report

Abstract We describe an extremely rare occurrence of a squamous differentiation in a sarcomatoid chromophobe renal cell carcinoma in a 45-year-old woman with nodal and lung metastasis at presentation. The tumor on histology showed all 3 components intimately admixed with each other, which to the best of our knowledge is the first such case to be reported in the literature. The renal pelvis was smooth walled and uninvolved. Kidney-specific cadherin was positive in the chromophobe renal cell carcinoma areas and negative in the sarcomatoid and squamous areas.

scholarly journals Hepatic Endometriosis Mimicking Metastatic Disease: A Case Report and Review of the Literature

2010 ◽  
Vol 4 (11) ◽  
Author(s):  
Mohamed Asran ◽  
Asif Rashid ◽  
Janio Szklaruk
Keyword(s):  
Case Report ◽  
Metastatic Disease ◽  
Review Of The Literature

Duodenal Gangliocytic Paraganglioma With Lymph Node Metastasis: A Case Report and Review of the Literature

2003 ◽  
Vol 127 (3) ◽  
pp. e139-e141 ◽  
Author(s):  
Vanitha Sundararajan ◽  
Toni M. Robinson-Smith ◽  
Andrew M. Lowy
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Metastatic Tumor ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Gangliocytic Paraganglioma ◽  
Regional Lymph Nodes ◽  
Current Case ◽  
Node Metastasis ◽  
Spindle Cells

Abstract A case of duodenal gangliocytic paraganglioma (DGP) in a 67-year-old woman is presented. The DGP arose in the second part of the duodenum. Although most of the reported cases of DGP are considered benign, in the present case, we found regional lymph nodes containing metastatic tumor. Previous reports have documented metastases containing only epithelioid cells. The current case demonstrates metastatic tumor in regional lymph nodes containing all 3 of the DGP components (spindle cells, ganglion-like cells, and epithelioid cells).

Urachal Malignant Fibrous Histiocytoma: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (4) ◽  
pp. 456-459
Author(s):  
Beverly Y. Wang ◽  
Alexander H. Boag ◽  
Muhammad Idrees ◽  
Iain D. Young ◽  
Pamela D. Unger
Keyword(s):  
Case Report ◽  
Metastatic Disease ◽  
Malignant Fibrous Histiocytoma ◽  
Mucinous Adenocarcinoma ◽  
Unusual Case ◽  
Fibrous Histiocytoma ◽  
Initial Diagnosis ◽  
Review Of The Literature ◽  
Urachal Remnant ◽  
Pathologic Processes

Abstract Pathologic processes involving the urachus are usually related to inflammatory or sinofistular conditions. Neoplasms rarely arise within this structure, and when they do occur, they are typically epithelial, with mucinous adenocarcinoma being the most common. Mesenchymal lesions, both benign and malignant, have rarely been described in this location. We report the case of a 66-year-old white man who presented with a primary urachal malignant fibrous histiocytoma and died of metastatic disease 20 months after the initial diagnosis. This is an unusual case of malignant fibrous histiocytoma arising in a urachal remnant.

An Aggressive Presentation of Colorectal Cancer With an Atypical Lymphoproliferative Pattern of Metastatic Disease: A Case Report and Review of the Literature

2014 ◽  
Vol 13 (3) ◽  
pp. e5-e11 ◽  
Author(s):  
Sonali M. Shah ◽  
Michael H. Rosenthal ◽  
Gabriel K. Griffin ◽  
Eric D. Jacobsen ◽  
Nadine J. McCleary
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
Metastatic Disease ◽  
Review Of The Literature

IgG4-Related Disease in the Frontal Convexity Concomitant with Smoldering Multiple Myeloma: A Case Report and Review of the Literature Regarding Therapeutic Implications

2020 ◽  
Vol 143 ◽  
pp. 247-260
Author(s):  
Toshihide Tanaka ◽  
Michiyasu Fuga ◽  
Akihiko Teshigawara ◽  
Yuzuru Hasegawa ◽  
Kaichi Nishiwaki ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Review Of The Literature ◽  
Therapeutic Implications ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Smoldering Multiple Myeloma

Morphologic shift associated with aberrant cytokeratin expression in a GIST patient after tyrosine kinase inhibitors therapy. A case report with a brief review of the literature

2016 ◽  
Vol 212 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Vincenzo Canzonieri ◽  
Daniela Gasparotto ◽  
Lara Alessandrini ◽  
Gianmaria Miolo ◽  
Elena Torrisi ◽  
...  
Keyword(s):  
Case Report ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Gist Patient ◽  
Review Of The Literature ◽  
Cytokeratin Expression

Ichthyosis Uteri: A Case Report and Review of the Literature

2005 ◽  
Vol 129 (5) ◽  
pp. e124-e125
Author(s):  
Chhanda Bewtra ◽  
Qing M. Xie ◽  
William J. Hunter ◽  
William Jurgensen
Keyword(s):  
Case Report ◽  
Squamous Metaplasia ◽  
Endometrial Adenocarcinoma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Squamous Cells ◽  
First Case

Abstract Squamous metaplasia of endometrium is mostly manifested by morules or nodules of benign nonkeratinizing squamous cells intimately mixed with benign or malignant endometrial glands. It has been described with low-grade adenocarcinoma of the endometrium, as well as with various benign conditions, including hyperplasia, chronic endometritis, and endometrial polyps. However, extensive plaquelike, keratinizing squamous change is distinctly uncommon. To our knowledge, we describe the first case of extensive benign squamous keratinization with underlying endometrial adenocarcinoma.

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