Effect of dietary lutein and flax on performance, egg composition and liver status of laying hens

2007 ◽  
Vol 87 (3) ◽  
pp. 365-372 ◽  
Author(s):  
S. Leeson ◽  
L. Caston ◽  
H. Namkung

Lutein is considered a protective nutrient against age-related macular degeneration in humans. An experiment was designed to study the long-term effect of feeding lutein in combination with flaxseed on layer performance, egg parameters, and lutein deposition in eggs and tissues. Laying hens were fed diets with 0 or 10% flax supplemented with 0, 125 or 250 ppm lutein for 11 consecutive 28-d periods beginning at 18 wk of age. Early production was reduced (P < 0.01) by feeding diets with 10% flax and when supplemented with 250 ppm lutein. Diet treatments had no effect on feed intake, egg weight or eggshell deformation. Addition of lutein to the diets significantly (P < 0.01) increased yolk color, and lutein content in the egg, liver, and the preen gland. Egg lutein content increased (P < 0.01) from a basal level of 0.10 mg to 1.60 mg 60g-1 egg by addition of lutein to the diet. Liver fat was lower (P < 0.05) in hens fed 10% flaxseed. Liver hemorrhage score was dramatically reduced (P < 0.01) in birds fed lutein. Key words: egg composition, flaxseed, lutein, layers

2019 ◽  
Vol 257 (7) ◽  
pp. 1459-1466 ◽  
Author(s):  
Alicia Valverde-Megías ◽  
Aurora Ruiz-Calvo ◽  
Antonio Murciano-Cespedosa ◽  
Samuel Hernández-Ruiz ◽  
Jose María Martínez-de-la-Casa ◽  
...  

2006 ◽  
Vol 141 (5) ◽  
pp. 863-867 ◽  
Author(s):  
Mauricio Figueroa ◽  
Lisa S. Schocket ◽  
Joan DuPont ◽  
Tatyana I. Metelitsina ◽  
Juan E. Grunwald

2016 ◽  
Vol 56 (1) ◽  
pp. 30-34 ◽  
Author(s):  
João Beato ◽  
Ana Catarina Pedrosa ◽  
João Pinheiro-Costa ◽  
Paulo Freitas-da-Costa ◽  
Manuel S. Falcão ◽  
...  

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 25
Author(s):  
Lara Macchioni ◽  
Davide Chiasserini ◽  
Letizia Mezzasoma ◽  
Magdalena Davidescu ◽  
Pier Luigi Orvietani ◽  
...  

Age-related retinal degenerations, including age-related macular degeneration (AMD), are caused by the loss of retinal pigmented epithelial (RPE) cells and photoreceptors. The pathogenesis of AMD, deeply linked to the aging process, also involves oxidative stress and inflammatory responses. However, the molecular mechanisms contributing to the shift from healthy aging to AMD are still poorly understood. Since RPE cells in the retina are chronically exposed to a pro-oxidant microenvironment throughout life, we simulated in vivo conditions by growing ARPE-19 cells in the presence of 10 μM H2O2 for several passages. This long-term oxidative insult induced senescence in ARPE-19 cells without affecting cell proliferation. Global proteomic analysis revealed a dysregulated expression in proteins involved in antioxidant response, mitochondrial homeostasis, and extracellular matrix organization. The analyses of mitochondrial functionality showed increased mitochondrial biogenesis and ATP generation and improved response to oxidative stress. The latter, however, was linked to nuclear factor-κB (NF-κB) rather than nuclear factor erythroid 2–related factor 2 (Nrf2) activation. NF-κB hyperactivation also resulted in increased pro-inflammatory cytokines expression and inflammasome activation. Moreover, in response to additional pro-inflammatory insults, senescent ARPE-19 cells underwent an exaggerated inflammatory reaction. Our results indicate senescence as an important link between chronic oxidative insult and detrimental chronic inflammation, with possible future repercussions for therapeutic interventions.


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