scholarly journals Risk of Death in Colorectal Cancer Patients with Multi-morbidities of Metabolic Syndrome: A Retrospective Multicohort Analysis

2020 ◽  
Author(s):  
Qingting Feng ◽  
Lingkai Xu ◽  
Lin Li ◽  
Junlan Qiu ◽  
Ziwei Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Cancer Patients ◽  
Risk Of Death ◽  
Colorectal Cancer Patients

scholarly journals The influence of metabolic syndrome in the outcomes of colorectal cancer patients

2017 ◽  
Vol 11 ◽  
pp. S867-S871 ◽  
Author(s):  
André Goulart ◽  
Ana Varejão ◽  
Fernanda Nogueira ◽  
Sandra Martins ◽  
António Mesquita-Rodrigues ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients.

1996 ◽  
Vol 14 (4) ◽  
pp. 1122-1127 ◽  
Author(s):  
A Yamaguchi ◽  
T Urano ◽  
T Goi ◽  
M Saito ◽  
K Takeuchi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Hematogenous Metastasis ◽  
High Recurrence Rate ◽  
Positive Staining ◽  
Cd44 Variant ◽  
Risk Of Death ◽  
Colorectal Cancer Patients

PURPOSE To determine the expression of the CD44 variant containing a variant exon 8 to 10 product (CD44v8-10) in colorectal cancer and to evaluate its prognostic value. MATERIALS AND METHODS CD44v8-10 was studied in resected tumors and normal mucosae obtained from 215 colorectal cancer patients (118 colon cancer and 97 rectal cancer). The expression of CD44v8-10 was analyzed immunohistochemically using the anti-CD44v8-10 monoclonal antibody (mAb) 44-1V. RESULTS One hundred of 215 cancer tissues expressed CD44v8-10. Positive staining was intense mainly on the cell membranes. There was no significant correlation between expression of CD44v8-10 and histologic type, primary tumor, lymphatic invasion, venous invasion, or peritoneal invasion. There were significant correlations between CD44v8-10 immunoreactivity and both lymph node and hematogenous metastasis. Patients with CD44v8-10-positive tumors had a greater relative risk of death compared with those whose tumors were CD44v8-10-negative. Among 169 patients who underwent curative resection, CD44v8-10 expression correlated with a high recurrence rate. The 5- and 10-year survival rates were 90.3% of patients with CD44v8-10-negative tumors, and 72.1% and 58.0% of those with CD44v8-10-positive tumors, respectively; these differences between the two groups of patients were significant (P < .01). In multivariate analysis using the Cox regression model, CD44v8-10 expression emerged as an independent prognostic indicator. CONCLUSION The results suggest that CD44v8-10 plays a role in metastasis of colorectal cancer, and tha CD44v8-10 expression may be a biologic marker of prognostic significance.

Metabolic syndrome and leptin are associated with adverse pathological features in male colorectal cancer patients

2012 ◽  
Vol 14 (2) ◽  
pp. 157-165 ◽  
Author(s):  
L. A. Healy ◽  
J. M. Howard ◽  
A. M. Ryan ◽  
P. Beddy ◽  
B. Mehigan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Cancer Patients ◽  
Pathological Features ◽  
Colorectal Cancer Patients

scholarly journals Association of Metabolic Syndrome and Cardiovascular Risk Factors Among Colorectal Cancer Patients Attending in Tikur Anbessa Specialized Hospital Oncology Units: A Comparative Cross-sectional Study June, 2017 Addis Ababa, Ethiopia

2020 ◽  
Author(s):  
Shimelis Adugna Elemo ◽  
Bereket Mihretu Awoke
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cancer Patients ◽  
Addis Ababa ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Colorectal Cancer Patients

Abstract Background: Metabolic syndrome and obesity are risk factors for developing type 2 diabetes mellitus and/or cardiovascular disease, especially stroke. Obesity-associated diseases account for a large portion of public health challenges. Among obesity-related disorders, a direct and independent relationship has been ascertained for colorectal cancer. Objective: The aim of this study was to determine the prevalence of metabolic syndrome and other cardiovascular risk factors, including dyslipidemia, hypertension, dietary and exercise practices, tobacco use and body mass index in individual with colorectal cancer patients attending Tikur Anbessa Hospital Oncology department, Addis Ababa.Methods: A comparative cross-sectional study was conducted from February, 2016 to Jun 2017 on 79 patients attending the Oncology clinic at Tikur Anbessa Hospital. Components of metabolic syndrome, including fasting serum glucose, serum triglyceride, serum high density lipoprotein, blood pressure and waist circumference, was measured in all of the patients. In addition, serum total cholesterol, serum low density lipoprotein was measured with 5010 photometers, and information gathered on smoking and other lifestyle practices, including diet and exercise.Result: Of 79 patients, 23 had metabolic syndrome (MS); 58.2% males; mean-age 48.6 years with range (26 to 78) and 41.8 % Female; mean age 44.6 years with range (20 to 78). Among the MS group, 45.6 % had high blood pressure, 26.6 % had increased waist circumference, 67.1% had serum blood glucose level greater than 100 mg/dL, 68.3 % had low high-density lipoprotein cholesterol level, 57 % had increased triglyceride level, and 3.8 % were obese [body mass index (BMI) >30 kg/m2]. 29 % presented 3 criteria of MS. From total colorectal cancer patients 53.2 % had colon cancer, 46.8 % had rectal cancer and 12.7 % had stage I,40.5 % had stage II (IIa,IIb & IIc), 25.3 % had stage III (a,b,c) and 21.5 % had stage IV disease.CONCLUSION: MS is positively associated with adenomas and colorectal cancer. However, there is not enough information in Ethiopia to justify screening in patients with MS. To our knowledge, no previous study has evaluated this association in Ethiopian patients.

Diabetes, Obesity, and the Metabolic Syndrome as Prognostic Factors in Stages I to III Colorectal Cancer Patients

2018 ◽  
Vol 50 (2) ◽  
pp. 221-229 ◽  
Author(s):  
Brianna Croft ◽  
Melissa Reed ◽  
Caitlyn Patrick ◽  
Natalie Kovacevich ◽  
Ioannis A. Voutsadakis
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
The Metabolic Syndrome ◽  
Colorectal Cancer Patients

scholarly journals Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

2017 ◽  
Vol Volume 10 ◽  
pp. 2199-2208 ◽  
Author(s):  
Jie You ◽  
Huxiang Zhang ◽  
Yanyan Shen ◽  
Chuanzhi Chen ◽  
Wenyue Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Cancer Patients ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Colorectal Cancer Patients

scholarly journals Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients

2019 ◽  
Vol 20 (3) ◽  
pp. 809-815 ◽  
Author(s):  
Elena A Tugutova ◽  
Svetlana N Tamkovich ◽  
Marina R Patysheva ◽  
Sergey G Afanas’ev ◽  
Anastasia A Tsydenova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

scholarly journals Changes of exosomal matrix metalloproteinases level in colorectal cancer associated with sex and metabolic disturbance

2019 ◽  
Vol 6 (3) ◽  
pp. 28-36
Author(s):  
N. V. Yunusova ◽  
E. A. Zambalova ◽  
M. R. Patysheva ◽  
A. A. Dimcha ◽  
O. V. Cheremisina ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Matrix Metalloproteinases ◽  
Cancer Patients ◽  
Metabolic Disorders ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Anthropometric Parameters ◽  
The Metabolic Syndrome ◽  
Colorectal Cancer Patients

The objective is to evaluate the contents of matrix metalloproteinases (MMP) MMP9, MMP2, as well as their inducer EMMPRIN in circulating exosomes of patients with colorectal cancer in relation with clinical and morphological parameters, as well as with the presence of metabolic syndrome to search for promising exosomal markers associated with invasion, metastasis and metabolic disorders.Materials and methods. The study included 40 patients with colorectal cancer (T2–4N0–2M0–1) and 10 control patients. Exosomes of blood plasma were isolated by ultrafiltration with ultracentrifugation. The level of MMP9, MMP2 and their inducer EMMPRIN in exosomes was evaluated by flow cytometry.Results and conclusion. The level of MMP9‑positive exosomes was significantly higher in patients with colorectal cancer compared with patients with colorectal polyps. The proportion of MMP9‑negative and triple positive MMP9 + / MMP2+ / EMMPRIN+ exosomes, on the contrary, was higher in patients with polyps compared with patients with colorectal cancer. Mixed subpopulation of MMP9+ / MMP2– / EMMPRIN-exosomes prevailed both in patients with colorectal cancer and in control patients. There were no significant differences in the subpopulations of MMP and EMMPRIN in the exosomes of colorectal cancer patients depending on the age, stage, grade and localization. Gender differences in the occurrence of a triple-positive exosome subpopulation in colorectal cancer patients have been revealed. No relationship was found between the expression of MMP and EMMPRIN in exosomes and the presence of the metabolic syndrome, anthropometric parameters, the level of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol. However, the relationships between MMP9+ / MMP2– / EMMPRIN–, MMP9+ / MMP2– / EMMPRIN– and the level of triglycerides and glucose in blood serum were revealed. Further studies are needed to study the characteristics of exosomes associated with metabolic disorders and the possibility of their use as diagnostic, prognostic, or predictor biomarkers.

scholarly journals Prognostic Value of Tumoral Thymidylate Synthase and p53 in Metastatic Colorectal Cancer Patients Receiving Fluorouracil-Based Chemotherapy: Phenotypic and Genotypic Analyses

2002 ◽  
Vol 20 (12) ◽  
pp. 2832-2843 ◽  
Author(s):  
Marie-Christine Etienne ◽  
Maurice Chazal ◽  
Pierre Laurent-Puig ◽  
Nicolas Magné ◽  
Christophe Rosty ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Thymidylate Synthase ◽  
Primary Tumor ◽  
Prognostic Value ◽  
Promoter Polymorphism ◽  
Risk Of Death ◽  
Biopsy Specimens ◽  
Colorectal Cancer Patients

PURPOSE: The aim of this multicenter prospective study was to evaluate the role of intratumoral parameters related to fluorouracil (FU) sensitivity in 103 metastatic colorectal cancer patients receiving FU–folinic acid. PATIENTS AND METHODS: Liver metastatic biopsy specimens were obtained for all patients and primary tumor biopsy specimens for 54 patients. Thymidylate synthase (TS), folylpolyglutamate synthetase, and dihydropyrimidine dehydrogenase were measured by radioenzymatic assays; TS promoter polymorphism (2R/2R v 2R/3R v 3R/3R) was determined by polymerase chain reaction; and p53 protein and mutations were analyzed by immunoluminometric assay and denaturing gradient gel electrophoresis, respectively. RESULTS: p53 mutations were observed in 56.7% of metastases. TS activity was significantly higher in 2R/3R tumors as compared with 2R/2R or 3R/3R. TS activity in metastasis was the only parameter linked to clinical responsiveness (responders exhibited the lower TS, P = .047). Univariate Cox analyses demonstrated that TS activity in primary tumor (the greater the TS, the poorer the survival; P = .040), TS promoter polymorphism in primary tumor (risk of death of 2R/3R v 2R/2R, 2.68; P = .035), and p53 stop mutation in metastasis (risk of death of stop mutations v wild type, 3.14; P = .018) were the only significant biologic predictors of specific survival. Stepwise analysis did not discriminate between TS activity and TS polymorphism. CONCLUSION: Present results confirm the value of tumoral TS activity for predicting FU responsiveness, point out the importance of detailed p53 mutation analysis for predicting survival, and suggest that TS genotype in primary tumor carries a prognostic value similar to that of TS activity.

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