Hydrogels as potential drug-delivery systems: network design and applications

2021 ◽  
Author(s):  
Hina Shoukat ◽  
Khuda Buksh ◽  
Sobia Noreen ◽  
Fahad Pervaiz ◽  
Irsah Maqbool
Keyword(s):  
Drug Delivery ◽  
Aqueous Solutions ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Specific Drug ◽  
Potential Drug ◽  
Physiological Conditions ◽  
Crosslinked Polymer ◽  
External Stimuli ◽  
Hydrophilic Network

Hydrogels are 3D crosslinked polymer matrices having a colossal tendency to imbibe water and exhibit swelling under physiological conditions without deformation in their hydrophilic network. Hydrogels being biodegradable and biocompatible, gained consideration due to some unique characteristics: responsiveness to external stimuli (pH, temperature) and swelling in aqueous solutions. Hydrogels offer a promising option for various pharmaceutical and biomedical applications, including tissue-specific drug delivery at a predetermined, controlled rate. This article presents a brief review of the recent and fundamental advances to design hydrogels, the swelling and deswelling mechanism, various crosslinking methods and their use as an intelligent carrier in the pharmaceutical field. Recent applications of hydrogels are also briefly discussed and exemplified.

scholarly journals Template-assisted extrusion of biopolymer nanofibers under physiological conditions

2016 ◽  
Vol 8 (10) ◽  
pp. 1059-1066 ◽  
Author(s):  
Mohammad Raoufi ◽  
Neda Aslankoohi ◽  
Christine Mollenhauer ◽  
Heike Boehm ◽  
Joachim P. Spatz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Physiological Conditions

Biomedical applications ranging from tissue engineering to drug delivery systems require versatile biomaterials based on the scalable and tunable production of biopolymer nanofibers under physiological conditions.

In vivo drug delivery applications of nanogels: a review

Nanomedicine ◽  
2020 ◽  
Vol 15 (27) ◽  
pp. 2707-2727
Author(s):  
Filippo Pinelli ◽  
Óscar Fullana Ortolà ◽  
Pooyan Makvandi ◽  
Giuseppe Perale ◽  
Filippo Rossi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Specific Drug ◽  
Drug Delivery Vehicles ◽  
In Vivo Assays ◽  
Wide Range ◽  
Delivery Vehicles ◽  
External Stimuli

In recent years, nanogels have emerged as promising drug delivery vehicles; their ability in holding active molecules, macromolecules and drugs, together with the capability to respond to external stimuli, makes them a suitable tool for a wide range of applications. These features allow nanogels to be exploited against many challenges of nanomedicine associated with different kinds of pathologies which require the use of specific drug delivery systems. In this review our aim is to give the reader an overview of the diseases that can be treated with nanogels as drug delivery systems, such as cancer, CNS disorders, cardiovascular diseases, wound healing and other diseases of human body. For all of these pathologies, biological in vivo assays can be found in the literature and in this work. We focus on the peculiarities of these nanogels, highlighting their features and their advantages in respect to conventional treatments.

Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

2020 ◽  
Vol 21 ◽  
Author(s):  
Dickson Pius Wande ◽  
Qin Cui ◽  
Shijie Chen ◽  
Cheng Xu ◽  
Hui Xiong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Dissolution ◽  
Glycol Succinate ◽  
Permeation Enhancer ◽  
P Glycoprotein ◽  
Us Fda ◽  
Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (4) ◽  
pp. 877-884 ◽  
Author(s):  
Po Li ◽  
Yue Yan ◽  
Binlong Chen ◽  
Pan Zhang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Interest ◽  
Upconversion Nanoparticles ◽  
Multifunctional Nanoparticles ◽  
Nano Oxide

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.

Halloysite-based hybrid bionanocomposite hydrogels as potential drug delivery systems

2017 ◽  
Vol 148 ◽  
pp. 48-55 ◽  
Author(s):  
Nooshin Sabbagh ◽  
Ali Akbari ◽  
Nasser Arsalani ◽  
Bagher Eftekhari-Sis ◽  
Hamed Hamishekar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Potential Drug
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