Adherence to Anti-retroviral Therapy among HIV Positive Pregnant Women in Ayder Refferal Hospital, Northern Ethiopia

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Wondale Shibabaw ◽  
Wondim Melkam ◽  
Agumas Shiabbaw
Keyword(s):  
Pregnant Women ◽  
Hiv Positive ◽  
Northern Ethiopia

scholarly journals ACE2, TMPRSS2 and L-SIGN expression in placentae from HIV-positive pregnancies exposed to antiretroviral therapy–implications for SARS-CoV-2 placental infection

2021 ◽  
Author(s):  
Smriti Kala ◽  
Ksenia Meteleva ◽  
Lena Serghides
Keyword(s):  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Viral Entry ◽  
Cell Entry ◽  
Hiv Positive ◽  
Mrna Levels ◽  
Black Race ◽  
Entry Receptor ◽  
Lower Expression ◽  
Human Placentae

Abstract Background SARS-CoV-2 binding receptor ACE2 and the spike protein priming protease TMPRSS2 are co-expressed in human placentae. It is unknown whether their expression is altered in the context of HIV infection and antiretroviral therapy (ART). Methods We compared mRNA levels of SARS-CoV-2 cell-entry mediators ACE2, TMPRSS2 and L-SIGN (an alternative entry receptor) by qPCR in 105 placentae: 45 from pregnant women with HIV (WHIV) exposed to protease inhibitor (PI)-based ART, 17 from WHIV on non-PI-based ART, and 43 from HIV-uninfected women. Results ACE2 levels were lower, while L-SIGN levels were higher in placentae from WHIV on PI-based ART as compared to those on non-PI-based ART and to HIV-uninfected women. TMPRSS2 levels were similar between groups. Black race was significantly associated with lower expression of ACE2 and higher expression of L-SIGN. ACE2 levels were significantly higher in placentae of female fetuses. Discussion We have identified pregnant women of Black race and WHIV who are on PI-based ART to have relatively lower expression of placental ACE2 than those of White race and HIV-uninfected women. This effect may potentially contribute to altered susceptibility to COVID-19 in these women, either favorably; by reduced viral entry, or detrimentally; by loss of ACE2 protection against hyperinflammation.

scholarly journals Asymptomatic bacteriuria among HIV positive pregnant women

Virulence ◽  
2010 ◽  
Vol 1 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Olutosin A. Awolude ◽  
Olubukola A. Adesina ◽  
Adesina Oladokun ◽  
W.B. Mutiu ◽  
Isaac F. Adewole
Keyword(s):  
Pregnant Women ◽  
Asymptomatic Bacteriuria ◽  
Hiv Positive

scholarly journals P208 Audit of the management of HIV positive pregnant women in a low prevalence setting

2016 ◽  
Vol 92 (Suppl 1) ◽  
pp. A89.1-A89
Author(s):  
Kasey Redler ◽  
Rebecca Hallgren ◽  
Rebecca Swingler
Keyword(s):  
Pregnant Women ◽  
Hiv Positive ◽  
Low Prevalence

scholarly journals Global Disease Outbreaks and Effects on Maternal, Newborn & Child Health in Global South, a Systematic Review

2020 ◽  
pp. 47-58
Author(s):  
O. Orjingene ◽  
N. L. Akondeng ◽  
A. Kone-Coulibaly ◽  
T. Ogojah ◽  
M. Ganama
Keyword(s):  
Health Care ◽  
Child Health ◽  
Pregnant Women ◽  
Low Income ◽  
Hospital Admissions ◽  
Disease Outbreaks ◽  
Global South ◽  
Hiv Positive ◽  
Newborn And Child Health ◽  
And Child Health

Background/Aim: The world has witnessed several disease outbreaks both in the past and in recent times. Apart from loss of lives as a result of such outbreaks, there are also disruptions in health care provision and utilization due to certain measures aimed at curtailing the spread of such outbreaks. This study aimed to seek evidence from existing literature on the effects of disease outbreaks on maternal, newborn and child health care in Global South. Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used and 14 literatures met the inclusion criteria. Results: HIV/AIDS pandemic affected the Maternal Newborn and Child Health since increased cases of anaemia, hospital admissions, still births in HIV positive pregnant and cases of foetal anaemia reported in infants born from HIV positive pregnant women were reported. No COVID-19 pandemic related-effects on MNCH observed since no maternal deaths and transmission from infected pregnant women to their newborns reported. Indirect effects of pandemics on MNHC include reduced service delivery and demand/utilization as well as inaccessibility due to diverse reasons. Discussion: The Government should put in place palliative measures for low-income citizens; engage and sensitize women, pregnant women and their children on available health care services and mitigation measures in place to access with minimal or no risk of being infected in a secure environment.

Prevalence and predictors of HIV-syphilis co-infection among HIV-infected pregnant women in China, 2011-2018

2020 ◽  
Author(s):  
Qian Wang ◽  
Xiao-Yan Wang ◽  
Xiaomeng Ma ◽  
Lori M Newman ◽  
Li-Xia Dou ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Pregnant Women ◽  
Junior High School ◽  
Case Reports ◽  
Care Service ◽  
Trend Test ◽  
Hiv Positive ◽  
Syphilis Infection ◽  
Transmitted Infection ◽  
Sexually Transmitted

Abstract Background The co-infection of Human Immunodeficiency Virus (HIV) and syphilis is risky for pregnant women and their expected children. In 2015, the Integrated Prevention of Mother-to-Child Transmission (iPMTCT) programwas established to offer all pregnant women with free screening, counseling, and testing of HIV and syphilis during regular obstetric inspections. To summarize the phase progress of this program, we reported the trends of maternal HIV-syphilis co-infection in China. We tried to socioeconomic factors associated with HIV-syphilis co-infection to inform the stratified control strategy for future work. Methods We obtained the prevalence data of HIV and syphilis over 2011–2018 by reviewing the Sexually Transmitted Infection (STI) monthly update reporting to the central surveillance system. With health status, background characteristics, and health outcomes reported, we collected the case reports from 2,578 HIV-positive pregnant women who accepted the screening at the local clinic. The trends of HIV and syphilis prevalence were examined using the Cochran-Armitage trend test. Logistic regression was applied to detect the features associated with syphilis infection among HIV-positive women and the potential risk factor to neonatal death. Results The prevalence of HIV decreased from 0.076–0.039% among registered pregnant women but increased slightly to 0.054% in 2018. The trend of syphilis prevalence in HIV-infected pregnant women fluctuated slightly around an average of 1.80% (p = .378). Multivariate logistic regression indicated finishing education of junior high school or below (aOR: 1.79, 95%CI: 1.31–2.43; p < .001), on regular Antiretroviral Therapy (ART) (aOR: 1.89, 95%CI: 1.47–2.45; p < .001) and exposed HIV from injective drug use (aOR: 5.49, 95%CI: 3.51–8.61; p < .001) are associated with high syphilis infection risk. Syphilis co-infection with HIV (aOR: 2.81, 95%CI: 1.32–5.96; p < .007) significantly increases the risk of newborns death. Conclusion Syphilis infection is still very prevalent in HIV-positive pregnant women five years after the implementation of iPMTCT program. Promoting the health education for maternal infection of STIs and increasing the availability of early intervention to link more marginalized women with care service should be the focuses of work in the next stage.

Sign in / Sign up

Export Citation Format

Share Document