Sexual behavior and oral HPV status of general dental patients

Men who have sex with men (MSM) harbor the highest prevalence of anal and oral Human Papillomavirus (HPV) infection, particularly if HIV-infected. We investigated anal and oral HPV infections in HIV-infected and HIV-uninfected MSM, to assess concurrent (HPV detected at both sites, irrespective of the genotypes), and concordant infections (same genotype[s] detected at both sites). Matched anal and oral samples from 161 MSM (85 HIV-infected, and 76 HIV-uninfected) were tested with the Linear Array. Determinants of concurrent and concordant infections were evaluated using logistic regression. Anal infections were 4 to 7 times more frequent than oral infections in both study groups (p < 0.0001). Concurrent infections were not significantly different in HIV-infected (25.9%) and HIV-uninfected MSM (17.1%), p = 0.18. A concordant infection was found in 15 MSM (9.3%). Concordance was for one genotype in 14 individuals and for four genotypes in the remaining subject. In the overall population, only age was independently associated with a concurrent infection (AOR = 3.10, 95% CI: 1.34–7.19 for >39 vs. ≤39 years). None of the parameters of sexual behavior showed independent association with concordant infections. Among MSM, concordant anal and oral HPV infections do not seem to be explained by sexual behavior, but might derive from sequential acquisition by autoinoculation.

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HLA-G Polymorphism Impacts the Outcome of Oral HPV Infections in Women

10.21203/rs.3.rs-251821/v1 ◽

2021 ◽

Author(s):

Anna Julia Jaakola ◽

Michel Roger ◽

Marie-Claude Faucher ◽

Kari Syrjänen ◽

Seija Grénman ◽

...

Keyword(s):

Human Leukocyte ◽

Hpv Infection ◽

Single Type ◽

Direct Dna Sequencing ◽

Leukocyte Antigen ◽

Hpv Status ◽

Increased Risk ◽

History Of ◽

Oral Hpv

Abstract Purpose: Human leukocyte antigen (HLA)-G may have an important role in the natural history of human papillomavirus (HPV) infection. Our aim was to evaluate the role of HLA-G in the outcome of genital and oral HPV infections in women. Methods: Analyses included 306 women from the Finnish Family HPV-study and were followed-up for six years. Genital and oral samples were tested for 24 different HPV types with multiplex HPV genotyping. HLA-G alleles were determined through direct DNA-sequencing. Unconditional logistic regression was used to determine the associations between HLA-G genotypes and HPV infection outcomes.Results: Nine HLA-G alleles were identified. Most common HLA-G genotypes were the wild type G*01:01:01/01:01:01 (31.3%) followed by G*01:01:01/01:01:02 (26.8%). G*01:01:01/01:01:01 genotype was associated with increased risk of oral HPV infections by any HPV type or single-type with OR=1.86 (95% CI 1.14-3.04) and 2.22 (95% CI 1.14 - 3.71), respectively. G*04:01+ allele and the G*01:01:01/01:04:01 genotype both protected from any and single oral HPV infections; OR=0.46 (95% CI 0.23-0.89) and 0.53 (95% CI 0.23-0.97), respectively. G*01:01:02/01:04:01 genotype increased significantly the risk of infertility and its treatments, with respective OR= 5.06 (95% CI 1.22-21.02) and OR=9.07 (95% CI 1.22-39.50). Both HLA-G alleles and genotypes showed several significant associations with the outcomes of oral HPV infections, but none of them had any impact on the outcomes of genital HPV infections in these women. Conclusion: The host HLA-G genotypes appear to impact the outcomes of oral HPV infections in women but have little if any effect on genital HPV status or infection outcomes.

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No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

Papillomavirus Research ◽

10.1016/j.pvr.2020.100207 ◽

2020 ◽

Vol 10 ◽

pp. 100207

Author(s):

Elgar Susanne Quabius ◽

Asita Fazel ◽

Christopher Knieling ◽

Stephan Gebhardt ◽

Martin Laudien ◽

...

Keyword(s):

Sexual Behavior ◽

Natural History ◽

German Population ◽

Critical View ◽

Tonsillar Tissue ◽

Hpv Status

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The impact of sexual behavior on oral HPV infections in young unvaccinated adults

Clinical Oral Investigations ◽

10.1007/s00784-015-1633-y ◽

2015 ◽

Vol 20 (7) ◽

pp. 1551-1557 ◽

Cited By ~ 5

Author(s):

D. Dalla Torre ◽

D. Burtscher ◽

E. Sölder ◽

A. Widschwendter ◽

M. Rasse ◽

...

Keyword(s):

Sexual Behavior ◽

Oral Hpv ◽

The Impact

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Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior

Oral Oncology ◽

10.1016/j.oraloncology.2015.06.005 ◽

2015 ◽

Vol 51 (9) ◽

pp. 832-838 ◽

Cited By ~ 43

Author(s):

Kristina R. Dahlstrom ◽

Diana Bell ◽

Duncan Hanby ◽

Guojun Li ◽

Li-E. Wang ◽

...

Keyword(s):

Sexual Behavior ◽

Smoking Status ◽

Oropharyngeal Carcinoma ◽

Socioeconomic Characteristics ◽

Hpv Status

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Prevalence, trends, and survival impact of human papillomavirus on oropharyngeal cancer in Indian population.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.5540 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 5540-5540

Author(s):

Ankur Bahl ◽

Lalit Dar ◽

BK Mohanti ◽

Pankaj Kumar ◽

Alok Thakar ◽

...

Keyword(s):

Sexual Behavior ◽

High Risk ◽

Alcohol Consumption ◽

Sexual Behaviors ◽

Blot Hybridization ◽

High Risk Sexual Behavior ◽

Hpv Prevalence ◽

Hpv Status ◽

Significant Difference ◽

Risk Sexual Behavior

5540 Background: Among oropharyngeal squamous cell carcinoma (OSCC), the true prevalence of HPV remains variable and studies have estimated that up to 60% may be HPV positive. Patients with HPV positive tumor are usuallyyounger in age, less likely to have history of tobacco or alcohol consumption and associated with a better prognosis but this information for Indian patients is largely unknown. Methods: 105 newly diagnosed patients of OSCC were enrolled. HPV genotyping was done on the biopsy specimen by consensus polymerase chain reaction and reverse line-blot hybridization assay. HPV prevalence was studied according to gender, age, tobacco and alcohol use and high risk sexual behavior. Results: Overall HPV prevalence was 22.8%. HPV positive patients were younger by 8 years as compared to negative patients (P=0.003). No significant correlation between tobacco consumption, alcoholic habits, and HPV status was observed. The mean number of life time sexual partners in HPV positive patients was 1.66 while, it was 1.33 in HPV negative patients (P=0.049). Incidence of high risk sexual behaviors was more in HPV positive patients (P<0.001). There were no significant associations between the two groups with respect to tumor size, nodal stage and the overall stage of the tumor. 16% of the base of tongue cancers and 40% of tonsillar carcinoma were positive (P = 0.02). Among positive samples, HPV 16 was the commonest (79%) followed by HPV 18 (12%). 96% of patients received treatment. At 18.8 months there was no significant difference in OS, EFS between HPV positive and negative OSCC (P = 0.97 and P= 0.51 respectively). Conclusions: The current study reconfirms that HPV positive OSCC patients are younger with high risk sexual behavior. Impact of smoking and alcohol consumption on HPV status was not found in this study. HPV positive rates were significantly higher for tonsillar cancer. Contrary to literature, we did not find any differences in OS or EFS between two groups. Small numbers of patients in the study group, short follow up period and significant tobacco smoking in HPV group may be the one of the reason for this.

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