scholarly journals Model Construction and Identification of Genome Instability-Associated LncRNA Signature Markers in Bladder Cancer

2022 ◽  
Vol 10 (01) ◽  
pp. 46-63
Author(s):  
Jun Li ◽  
Hui Pan ◽  
Xiaowu Pi ◽  
Ying Xiong
Keyword(s):  
Bladder Cancer ◽  
Genome Instability ◽  
Model Construction

scholarly journals Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells

2021 ◽  
Vol 22 (5) ◽  
pp. 2553
Author(s):  
Przemysław A. Stempor ◽  
Dror Avni ◽  
Raya Leibowitz ◽  
Yechezkel Sidi ◽  
Maria Stępień ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Genome Instability ◽  
Expression Profiles ◽  
Personalised Medicine ◽  
Regulation Of Gene Expression ◽  
Good Prognosis ◽  
Response To Treatment ◽  
Therapeutic Modalities ◽  
Cancer Pathogenesis

Personalised medicine is the future and hope for many patients, including those with cancers. Early detection, as well as rapid, well-selected treatment, are key factors leading to a good prognosis. MicroRNA mediated gene regulation is a promising area of development for new diagnostic and therapeutic methods, crucial for better prospects for patients. Bladder cancer is a frequent neoplasm, with high lethality and lacking modern, advanced therapeutic modalities, such as immunotherapy. MicroRNAs are involved in bladder cancer pathogenesis, proliferation, control and response to treatment, which we summarise in this perspective in response to lack of recent review publications in this field. We further performed a correlation-based analysis of microRNA and gene expression data in bladder cancer (BLCA) TCGA dataset. We identified 27 microRNAs hits with opposite expression profiles to genes involved in immune response in bladder cancer, and 24 microRNAs hits with similar expression profiles. We discuss previous studies linking the functions of these microRNAs to bladder cancer and assess if they are good candidates for personalised medicine therapeutics and diagnostics. The discussed functions include regulation of gene expression, interplay with transcription factors, response to treatment, apoptosis, cell proliferation and angiogenesis, initiation and development of cancer, genome instability and tumour-associated inflammatory reaction.

scholarly journals Racial differences in genomic features and new trans-ancestry prognosis subtypes in bladder cancer

2021 ◽  
Author(s):  
Baifeng Zhang ◽  
Peilin Jia ◽  
Jiayin Wang ◽  
Guangsheng Pei ◽  
Changxi Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Racial Differences ◽  
Large Scale ◽  
Genome Instability ◽  
Good Prognosis ◽  
Molecular Features ◽  
Novel Association ◽  
Different Populations ◽  
Muscle Invasive ◽  
Somatic Copy Number Alterations

Abstract The incidence and survival of bladder cancer vary greatly among different populations but the influence of the associated molecular features and evolutionary processes on its clinical treatment and prognostication remains unknown. Here, we analyze the genomic architectures of over 500 bladder cancer patients from Asian/Black/White populations. We identify novel association between AHNAK mutations and APOBEC-a mutational signature whose activities vary substantially across populations. All significantly mutated genes but only half of arm-level somatic copy number alterations (SCNAs) are enriched with clonal events, indicating large-scale SCNAs as rich sources fostering bladder cancer clonal diversities. The prevalence of TP53 and ATM clonal mutations as well as the associated burden of SCNAs is significantly higher in Whites/Blacks than in Asians. We identify a trans-ancestry prognostic subtype of bladder cancer characterized by: enrichment of non-muscle-invasive patients and muscle-invasive patients with good prognosis, increased CREBBP/FGFR3/HRAS/NFE2L2 mutations, decreased intra-tumor heterogeneity and genome instability and activated tumor microenvironment.

Sex and Racial Disparities in the Treatment and Outcomes of Muscle-invasive Bladder Cancer

Urology ◽  
2020 ◽  
Author(s):  
Jessica Marinaro ◽  
Alexander Zeymo ◽  
Jillian Egan ◽  
Filipe Carvalho ◽  
Ross Krasnow ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Racial Disparities ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

775: Cell Culture Proteome Identifies CXCL 1 as a Secreted Marker and Mediator for the Tumor Invasion of Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 260-260 ◽  
Author(s):  
Hiroaki Kawanishi ◽  
Yoshiyuki Matsui ◽  
Toshinari Yamasaki ◽  
Takeshi Takahashi ◽  
Hiroyuki Nishiyama ◽  
...  
Keyword(s):  
Cell Culture ◽  
Bladder Cancer ◽  
Tumor Invasion

774: Improvement of Anti-Angiogenic and Anti-Tumorigenic Efficacy of Thrombospondin-1 by PPAR┌ Ligands in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 259-259
Author(s):  
Thomas Nelius ◽  
Hanua Huang ◽  
Stephanie Filleur ◽  
Steven C. Campbell ◽  
Werner de Riese ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Thrombospondin 1 ◽  
Ppar Ligands

769: Matrix Metalloproteinase Polymorphisms are associated with Bladder Cancer Invasiveness

2007 ◽  
Vol 177 (4S) ◽  
pp. 258-258
Author(s):  
A. Karim Kader ◽  
Jun Liu ◽  
Una Shao ◽  
Colin P.N. Dinney ◽  
Jie Lin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Invasiveness

764: Differential Expression of RAL GTPases and their Effectors in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 256-256
Author(s):  
Steven Smith ◽  
Gary Oxford ◽  
Dan Theodorescu
Keyword(s):  
Bladder Cancer ◽  
Differential Expression ◽  
Ral Gtpases

761: Enhanced Chemosensitivity to CPT-11 by a Novel NF-KB Inhibitor, DHMEQ in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 255-255
Author(s):  
Eiji Kikuchi ◽  
Jun Nakashima ◽  
Keiichi Yamazaki ◽  
Akira Miyajima ◽  
Yutaka Horiguchi ◽  
...  
Keyword(s):  
Bladder Cancer

758: Inflammatory and Anti-Inflammatory Regulators alter Levels of an Inhibitor of Apoptosis (IAP), Survivin, in T-24 Bladder Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 254-254
Author(s):  
Justin J. Cohen ◽  
Bayan T. Takizawa ◽  
Hristos Z. Kaimkliotis ◽  
David J. Rosenberg ◽  
Marcia A. Wheeler ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitor Of Apoptosis ◽  
Bladder Cancer Cells ◽  
Anti Inflammatory
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