scholarly journals Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer

2015 ◽  
Vol 14 (2) ◽  
pp. 5390-5398 ◽  
Author(s):  
Y. Dong ◽  
J.W. Liu ◽  
Y.J. Gao ◽  
T. Zhou ◽  
Y.M. Chen
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Repair Gene ◽  
Single Nucleotide ◽  
Dna Repair Gene

Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy

2011 ◽  
Vol 99 (2) ◽  
pp. 231-234 ◽  
Author(s):  
Robert J.S. Murray ◽  
George A. Tanteles ◽  
Jamie Mills ◽  
Angus Perry ◽  
Irene Peat ◽  
...  
Keyword(s):  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Repair Gene ◽  
Skin Reactions ◽  
Single Nucleotide ◽  
Dna Repair Gene

Single nucleotide polymorphisms of the DNA repair gene XPD/ERCC2 alter mRNA expression

2007 ◽  
Vol 17 (11) ◽  
pp. 897-905 ◽  
Author(s):  
Kevin J. Wolfe ◽  
Jeffrey K. Wickliffe ◽  
Courtney E. Hill ◽  
Moreno Paolini ◽  
Marinel M. Ammenheuser ◽  
...  
Keyword(s):  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Mrna Expression ◽  
Nucleotide Polymorphisms ◽  
Repair Gene ◽  
Single Nucleotide ◽  
Dna Repair Gene

scholarly journals DNA Repair Gene Polymorphisms and Susceptibility to Urothelial Carcinoma in a Southeastern European Population

2021 ◽  
Vol 28 (3) ◽  
pp. 1879-1885
Author(s):  
Maria Samara ◽  
Maria Papathanassiou ◽  
Lampros Mitrakas ◽  
George Koukoulis ◽  
Panagiotis J. Vlachostergios ◽  
...  
Keyword(s):  
Dna Repair ◽  
Urothelial Carcinoma ◽  
European Population ◽  
Nucleotide Polymorphisms ◽  
Environmental Carcinogens ◽  
Repair Gene ◽  
High Exposure ◽  
Dna Repair Gene ◽  
Increased Risk ◽  
Xrcc3 Thr241met

Single nucleotide polymorphisms (SNPs) in DNA repair genes may predispose to urothelial carcinoma of the bladder (UCB). This study focused on three specific SNPs in a population with high exposure to environmental carcinogens including tobacco and alcohol. A case-control study design was used to assess for presence of XPC PAT +/−, XRCC3 Thr241Met, and ERCC2 Lys751Gln DNA repair gene SNPs in peripheral blood from patients with UCB and healthy individuals. One hundred patients and equal number of healthy subjects were enrolled. The XPC PAT +/+ genotype was associated with a 2-fold increased risk of UCB (OR = 2.16; 95%CI: 1.14–4; p = 0.01). The −/+ and +/+ XPC PAT genotypes were more frequently present in patients with multiple versus single tumors (p = 0.01). No association was detected between ERCC2 Lys751Gln genotypes/alleles, and risk for developing UCB. Presence of the XRCC3 TT genotype (OR = 0.14; 95%CI:0.07–0.25; p < 0.01) and of the T allele overall (OR = 0.26; 95%CI:0.16–0.41; p < 0.01) conferred a protective effect against developing UCB. The XPC PAT −/+ and XRCC3 Thr241Met SNPs are associated with predisposition to UCB. The XPC PAT −/+ SNP is also an indicator of bladder tumor multiplicity, which might require a more individualized surveillance and treatment.

Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide

2011 ◽  
Vol 35 (9) ◽  
pp. 1178-1183 ◽  
Author(s):  
María Teresa Cibeira ◽  
Carlos Fernández de Larrea ◽  
Alfons Navarro ◽  
Tania Díaz ◽  
Dolors Fuster ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Refractory Multiple Myeloma
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