Background:
Dental caries originate due to the localized dissolution of the hard tissues of
teeth, mainly caused by acids, developed by the presence of microorganisms in the biofilm (dental
plaque) on the surface of teeth causing “cavities”. Commercially available liquid mouthwashes containing
synthetic active ingredients possess limitations like teeth staining, higher alcoholic content,
taste disturbances, xerostomia, and stability issues.
Objective:
To make the solid preparation for oral hygiene (US6428770B1) in the form of herbal effervescent
mouthwash tablet (CN106619318A, US8728446B2) using Azadirachta indica and Curcumin
having antimicrobial, antibacterial, antiplaque, and anti-inflammatory activity.
Methods:
The optimization study of effervescent granules was performed by 33 factorial design. A
total of 27 preliminary experimental batches were prepared by the fusion method, varying the amount
of citric acid, tartaric acid, and sodium bicarbonate. A complex of curcumin was prepared with hydroxyl
propyl β-cyclodextrin and further examined by scanning electron microscopy. The prepared
tablets were evaluated for pre and post-compression parameters. The in vitro antimicrobial study was
performed by Agar well diffusion method against S. mutans.
Results:
All the experimental batches of effervescent granules were evaluated for pH, effervescent
time, and CO2 content. Six batches were further selected for final tablet preparation. The results of the
pre-compression parameters revealed excellent flow properties and post-compression parameters; the
results were also significant. The antimicrobial study revealed the F3 as a final best formulation.
Conclusion:
The developed herbal formulation (F3) has a good potential to maintain oral hygiene as
compared to alcoholic mouthwash and further studies may be necessary to confirm the efficacy of the
formulation since only a single bacterial strain was assayed.
Phytochemical, Histochemical and in-vitro Antimicrobial Study of Various Solvent Extracts of Costus speciosus (J.Koenig) Sm. and Costus pictus D. Don
