Comparison of Platelet-rich Plasma and Cortisone Injections Administered Under Ultrasonography Guidance in Rotator Cuff Tendon Pathologies

Background: Clinical research on the rotator cuff tendon is increasing, and new approaches are being applied to rotator cuff disease. Considering the integration of research resources and research trends, it is necessary to conduct an analysis of recent research on the topic. Purpose: To identity the research trends, influential journals, key researchers, and core countries of rotator cuff tendon research between 2000 and 2019. Study Design: Cross-sectional study. Methods: All the literature related to rotator cuff tendon research was retrieved from the Web of Science Core Collection on January 7, 2020. Qualitative and quantitative analyses were processed based on Web of Science and CiteSpace. Results: A total of 4131 studies, which included 3830 articles and 301 reviews, were obtained. There was an upward trend of studies on the topic, with small fluctuations in the past 2 decades. The United States had the most studies, and the number of studies from other countries increased over the study period. Most of the funding sources came from the United States. Articles in the Journal of Shoulder and Elbow Surgery had the most citations for rotator cuff research. Frontier topics, such as arthroscopic repair, mesenchymal stem cell, and “platelet-rich plasma, were identified. The number of citations in 2018 ( r = 0.280; P = .005) and 2019 ( r = 0.307; P = .002) had a weak positive correlation with publication date, indicating that the more recently published articles had a higher number of citations. Conclusion: Valuable information on rotator cuff research based on bibliometric analysis was identified. Arthroscopic repair, mesenchymal stem cell, and platelet-rich plasma might be the research frontiers in this field, and researchers should focus on these topics in future studies.

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Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-017-0693-x ◽

2018 ◽

Vol 13 (1) ◽

Cited By ~ 32

Author(s):

Sang Jun Kim ◽

Eun Kyung Kim ◽

Sun Jeong Kim ◽

Da Hyun Song

Keyword(s):

Bone Marrow ◽

Rotator Cuff ◽

Bone Marrow Aspirate ◽

Platelet Rich Plasma ◽

Rotator Cuff Tendon ◽

Partial Tear ◽

Bone Marrow Aspirate Concentrate

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Effect of Bone Marrow Aspirate Concentrate-Platelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear

Cell Transplantation ◽

10.3727/096368917x694705 ◽

2017 ◽

Vol 26 (5) ◽

pp. 867-878 ◽

Cited By ~ 24

Author(s):

Sun Jeong Kim ◽

Da Hyun Song ◽

Jong Wook Park ◽

Silvia Park ◽

Sang Jun Kim

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Rotator Cuff ◽

Bone Marrow Aspirate ◽

Platelet Rich Plasma ◽

Immunocytochemical Staining ◽

Osteogenic Potential ◽

Tendon Tear ◽

Rotator Cuff Tendon ◽

Significant Difference

Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon-derived stem cells (TDSCs), but there has been no study about the effect of the BMAC–PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC–PRP on the TDSCs and to find the therapeutic effect of BMAC–PRP on the rotator cuff tendon tear. The chondrogenic and osteogenic potential of TDSCs decreased, but the adipogenic potential of TDSCs revealed no significant difference when they were cocultured with BMAC–PRP. Cell proliferation was significantly greater in TDSCs cocultured with BMAC–PRP than in TDSCs. The degree of wound closure (percentage) was different between TDSCs and TDSCs with BMAC–PRP. There was no significant difference in expression of collagen type I and type III in immunocytochemical staining in the presence of BMAC–PRP. Initial visual analog scale (VAS) score was 5.8±1.9, which changed to 5.0±2.3 at 3 weeks and 2.8±2.3 at 3 months after the BMAC–PRP injection ( p<0.01). The American Shoulder Elbow Surgeon score changed from 39.4±13.0 at baseline to 52.9±22.9 at 3 weeks and 71.8±19.7 at 3 months after the injection ( p<0.01). The initial torn area of the rotator cuff tendon was 30.2±24.5 mm2, and this area was reduced to 22.5±18.9 mm2 at 3 months, but the change was not significant ( p > 0.05). The data indicate that BMAC–PRP enhances the proliferation and migration of TDSCs and prevents the aberrant chondrogenic and osteogenic differentiation of TDSCs, which might provide a mechanistic basis for the therapeutic benefits of BMAC–PRP for rotator cuff tendon tear.

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Comparative Analysis of Platelet-rich Plasma Effect on Tenocytes from Normal Human Rotator Cuff Tendon and Human Rotator Cuff Tendon with Degenerative Tears

Clinics in Shoulder and Elbow ◽

10.5397/cise.2018.21.1.3 ◽

2018 ◽

Vol 21 (1) ◽

pp. 3-14 ◽

Cited By ~ 1

Author(s):

Jeong Yong Yoon ◽

Seung Yeon Lee ◽

Sue Shin ◽

Kang Sup Yoon ◽

Chris Hyunchul Jo

Keyword(s):

Gene Expression ◽

Cell Proliferation ◽

Rotator Cuff ◽

Platelet Rich Plasma ◽

Type I ◽

Rotator Cuff Tendon ◽

Tenascin C ◽

Matrix Gene ◽

Collagen Iii ◽

Human Rotator Cuff

BACKGROUND: Platelet-rich plasma (PRP) stimulates cell proliferation and enhances matrix gene expression and synthesis. However, there have been no comparative study of the PRP effect on the normal and degenerative tenocytes. The purpose of this study was to compare the effect of PRP on tenocytes from normal and degenerative tendon.METHODS: Tendon tissues were obtained from patients undergoing arthroscopic repair (n=9) and from healthy donors (n=3). Tenocytes were cultured with 10% (vol/vol) platelet-poor plasma, PRP activated with calcium, and PRP activated with calcium and thrombin. The total cell number was assessed at days 7 and 14. The expressions of type I and III collagen, decorin, tenascin-C, and scleraxis were evaluated by quantitative real-time reverse transcriptase polymerase chain reaction. The total collagen and glycosaminoglycan (GAG) synthesis was evaluated at days 7 and 14.RESULTS: No differences were observed between the groups at day 7, but cell proliferation was remarkably increased in tenocytes from the degenerative tendon at day 14. In both tenocyte groups, the gene expressions of type I and III collagen were up-regulated. GAG synthesis was greater in the normal tendon, whereas the expressions of decorin and tenascin-C were increased in tenocytes from the degenerative tendon. Tenocytes from the degenerative tendon had higher fold-change of GAG synthesis and a lower collagen III/I ratio than normal tenocytes.CONCLUSIONS: PRP promoted the cell proliferation and enhanced the synthesis of tendon matrix in both groups. PRP has a greater positive effect on cell proliferation, matrix gene expression and synthesis in tenocytes from degenerative tendon.

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