scholarly journals Effects of aqueous leaf extract of Mucuna Pruriens (Linn.) on the weight and histology of the testis and epididymis in adult male Wistar rats

2019 ◽  
Vol 23 (5) ◽  
pp. 825
Author(s):  
R.A. Orheruata ◽  
A. Ejeguo ◽  
C.L. Sakpa
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Mucuna Pruriens ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

scholarly journals The effect of aqueous leaf extract of Adansonia digitata (baobab) on diabetes mellitus and the anterior pituitary of adult male wistar rats

2019 ◽  
Vol 10 (3) ◽  
pp. 18-29
Author(s):  
Pamela Okorie ◽  
Francis Agu ◽  
Celestine Ani ◽  
Ifeoma Alozie ◽  
Choice Nworgu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adult Male ◽  
Anterior Pituitary ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Adansonia Digitata ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

Profertility effects of aqueous leaf extract of Telfairia occidentalis in adult male Wistar rats

2015 ◽  
Vol 14 (2) ◽  
pp. 88 ◽  
Author(s):  
SakpaLucky Christopher ◽  
Onovughakpo-SakpaOriseseyigbemi Ejuoghanran ◽  
OkhimamheAkhalumhe Festus
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Telfairia Occidentalis ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

scholarly journals Phytochemical Evaluation and Acute Toxicity Study of Ethanol Leaf Extract of Acalypha wilkesiana

2021 ◽  
Vol 2 (8) ◽  
pp. 715-720
Author(s):  
Anthony Osamuyi Iyamu ◽  
Uwaifoh Akpamu ◽  
Karen Uwarobehi Iyamu
Keyword(s):  
Acute Toxicity ◽  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Proximate Analysis ◽  
Qualitative And Quantitative ◽  
Benin City ◽  
Synthetic Drugs ◽  
Male Wistar Rats ◽  
Acalypha Wilkesiana

Increased curiosity on natural plant products has been raised due to problems of cost, unavailability, and after-effects of countless synthetic drugs. Worrisome, many plant-derived formulations lack phytochemically or toxicological screening. Hence, this study phytochemical and elemental screened the ethanolic leaf extract of Acalypha wilkesiana and as well as determining acute toxicity in adult male Wistar rats. The leaves were obtained in Benin City, Nigeria. Ethanol extraction was carried out on leaves and the extract was subjected to proximate, qualitative, and quantitative phytochemical screening and elemental analysis. Acute toxicity was determined on 12 adult male Wistar rats following Lork’s method. Proximate analysis revealed a high presence of carbohydrate, ash, fiber, and moisture. The qualitative and quantitative evaluation showed the abundance of alkaloids (68.7 ± 0.120%), flavonoids (34.7 ± 0.001%) and minute (<1mg/g) saponins, tannins, phenol, and terpenes. The extract contain nutritive (vitamin E = 1.184 ± 0.055µg/g; vitamin A = 0.0066 ± 0.003µg/g; vitamin C = 0.046 ± 0.037µg/g) and anti-nutritive (oxalates = 229.780 ± 16.93mg/100g; cyanide=0.162 ± 0.006 mg/100g; phytate = 0.131 ± 0.01mg/100g) elements. The elemental evaluation showed an abundance of potassium, sodium, and chloride with traces of cadmium and lead and the absence of manganese and copper. There was no sign of acute toxicity or mortality at an extract dose of 5000mg/kg. These findings indicate the ethanol leaf extract of A. wilkesiana as a rich source of phytochemicals and major macro elements and high safety at 5000mg/kg dose. Considering the several components in the leaves extract, Acalypha wilkesiana leaf might be pharmacological significant for the biological system.

scholarly journals Effects of Aqueous Leaf Extract of Simarouba glauca DC (Simaroubaceae) on Lipoprotein Homeostasis and Oxidative Stress Biomarkers

2021 ◽  
Vol 1 (1) ◽  
pp. 20-29
Author(s):  
Sammydavies E. Osagie-Eweka ◽  
Noghayin J. Orhue ◽  
Eric I. Omogbai
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Biologically Active ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract ◽  
Simarouba Glauca ◽  
And Oxidative Stress

Background and Purpose: Simarouba glauca is widely reported to contain a number of biologically active compounds with potentials in the treatment of numerous diseases. The study was conducted to evaluate the sub-acute effects of the aqueous leaf extract of Simarouba glauca (AESG) on lipoproteins and oxidative stress biomarkers in male Wistar rats. Methods: Oral administration of AESG was carried out in line with the guidelines of the Organization for Economic Co-operation and Development (OECD), No. 425 using a total of 24 male Wistar rats allotted to four groups (n=6); given distilled water, 500, 1000, and 2000 mg/kg/day of AESG respectively for 30 days. Results: In plasma, there was a significant reduction (P?0.05) in HDL-cholesterol; elevated (P?0.05) triglycerides (TG) at 1000 and 2000 mg/kg/day; elevated (P?0.05), and LDL-cholesterol at 500 and 1000 mg/kg/day, relative to the control. While the level of liver total cholesterol (TC) reduced significantly, it increased in the heart. Catalase (CAT) activity in the liver increased significantly (P?0.05) at all doses. The dose of 1000 mg/kg/day significantly (P?0.05) elevated kidney CAT activity. The activities of superoxide dismutase (SOD) in liver and heart reduced (P?0.05) at 500 mg/kg/day. At all doses, the levels of reduced glutathione (GSH) in plasma, liver and heart were comparable with the control. Although, there were no significant changes in plasma and liver glutathione peroxidase (GSH-PX) activity at all doses, animals given 500 mg/kg had reduction (P?0.05) in the heart GSH-PX activity compared to the control. Conclusion: Oral sub-acute AESG at high doses altered lipid homeostasis in plasma and heart without lipid peroxidation or oxidative stress. The extract has the potential to cause hyperlipidemia.

scholarly journals Hepato-Renal Activities of Hydro-Methanol Leaf Extract of Cnidoscolus aconitifolius in Adult Male Wistar Rats

2021 ◽  
Vol 11 (4) ◽  
pp. 5-9
Author(s):  
Ijeoma Ezebuiro ◽  
Avweresuoghene Ododo ◽  
Uchechukwu Ifeanyichukwu Apugo
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Negative Control ◽  
Protective Agent ◽  
Treatment Groups ◽  
Cnidoscolus Aconitifolius ◽  
Group I ◽  
Male Wistar Rats ◽  
Liver And Kidney

Introduction: Medicinal plants such as Cnidoscolus aconitifolius (CA) have been studied over the years for their protective and curative potentials against a myriad of common global health challenges such as hepatorenal injuries. Objectives: To ascertaining the effects of the hydromethanol leaf extract of CA (HMLECA) on hepato-renal parameters in adult male wistar rats. Method: A total of 18 adult male wistar rats were divided into 3 groups of six rats each. Group I served as the negative control which received distilled water while groups 2 and 3 served as extract treatment groups which received 200 and 400 mg/kg BW of the HMLECA respectively. The administration was daily for a period of 58 days while blood sample for the biochemical analysis was drawn via cardiac puncture at the end of the study following light chloroform anaesthesia. Results and Discussion: The results showed that the administration of both doses of the extract produced no significant (P<0.05) effect on the levels of serum liver enzyme (AST, ALT, ALP), TP, ALB, electrolytes (K+, Na+ and HCO3–), Creatinine and Urea while that of the 400 mg/kg BW produced significant (P<0.05) decrease in the level of TB and Cl –. Hence, the administration of the leaf extract in this study did not elicit any toxic effect on both the liver and kidney functions and could be effective as hepato-renal protective agent. Keywords: Cnidoscolus aconitifolius, Liver function, Liver enzymes, Renal function, Serum biochemicals, Serum electrolytes

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