Frequency of Gingivitis among 12 to 70 Years Old Patients Visiting Lady Reading Hospital, Peshawar, Pakistan: A Cross Sectional Study

The present cross sectional study aimed to determine the frequency of gingivitis among 21 to 70 old patients at Periodontal Department of Lady Reading Hospital (LRH), Peshawar, Pakistan. A total of 133 patients were observed by using Word Health Organization (WHO) sample size calculator with the following assumption, confidence level = 95%, Anticipated absolute precision = 8% and Population proportion = 33.4%. Standard proforma (questionnaire) and non-probability consecutives sampling technique was used for the sample collection with inclusion and exclusion base criteria for the study fulfillment. Results showed that mean age was 60 years with standard deviation + 8.34. 63 (47.36%) of patients were male and 70 (52.63%) were female. Male patients had gingival inflammation affected more 50 (79.36%) as compared to female 17 (24.28%). Total sample prevalence of mild, moderate and sever gingivitis was 43 (64.17%), 20 (29.85%) and 4 (5.97%). Percentage of mild gingivitis in females was less than males (58.82% vs. 66%), moderate gingivitis percentage was also slightly less in females than males (29.41% vs. 30%). However percentage of females having severe gingivitis was found higher than males (11.76% vs. 4%). Out of 133 patients 67 (50.37%) were analyzed as gingivitis while 66 (49.62%) patients were without gingivitis. It was revealed that the incidence rate of gingivitis was estimated 67 (50.37%) among 133 patients. Patients should need awareness of gingivitis through proper education channel as a result to adopt appropriate oral hygiene practices and other preventive measures to reduce the incidence of this disease and other oral health complications in future.

Metal-Based Nanomaterials Incorporate with Ultrasound as Acceptable Approach towards Cancer Therapy

Among current biological researches, there have a plenty of works related cancer therapy issues by using functional or pure-phased composites in non-invasive strategies. Especially in fabricating anticancer candidates, functional composites are divided into different sorts with different characteristics. Additionally, nanotechnology provides various approaches in utilizing composites’ functionality for cancer diagnostics and therapeutics. Compared with previous Photodynamic Therapy (PDT), Photo-Thermal Therapy (PTT), chemotherapy and radiotherapy, ultrasound is used to activate sonosensitizer to produce cytotoxic Reactive Oxygen Species (ROS) toward target cancer cells. In recent years, the form of Sonodynamic Therapy (SDT) has been making much effort to develop highly efficient metal based Nanomaterials (NMs) as sonosensitizers, which can efficiently generate ROS and has the advantages of deeper tissue penetration. However, the traditional sonosensitizers, such as porphyrins, hypericin, and curcumins suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy. For contrasting this limitation, the metal based inorganic NMs show biocompatibility, controllable physicochemical properties, and ease of achieving multifunctional properties, which greatly expanded their application in SDT. In this review, we systematically summarize the metal based inorganic NMs as carrier of molecular sonosensitizers, and produce ROS under ultrasound. Moreover, the prospects of advanced metal based further materials application are also discussed.

Physicochemical and Analytical Implications of GATES/GEB Principles

The fundamental property of electrolytic systems involved with linear combination f12 = 2∙f(O) – f(H) of elemental balances: f1 = f(H) for Y1 = H, and f2 = f(O) for Y2 = O, is presented. The dependency/independency of the f12 on Charge Balance (f0 = ChB) and other elemental and/or core balances fk = f(Yk) (k = 3,…,K) is the general criterion distinguishing between non-redox and redox systems. The f12 related to a redox system is the primary form of a Generalized Electron Balance (GEB), formulated for redox systems within the Generalized Approach to Electrolytic System (GATES) as GATES/GEB ⊂ GATES. The set of K balances f0,f12,f3,…,fK is necessary/ sufficient/needed to solve an electrolytic redox system, while the K-1 balances f0,f3,…,fK are the set applied to solve an electrolytic non-redox system. The identity (0 = 0) procedure of checking the linear independency/ dependency property of f12 within the set f0,f12,f3,…,fK (i) provides the criterion distinguishing between the redox and non-redox systems and (ii) specifies Oxidation Numbers (ONs) of elements in particular components of the system, and in the species formed in the system. Some chemical concepts, such as oxidant, reductant, oxidation number, equivalent mass, stoichiometry, perceived as derivative within GATES, are indicated. All the information is gained on the basis of the titration Ce(SO4)2 (C) + H2SO4 (C1) + CO2 (C2) ⇨ FeSO4 (C0) + H2SO4 (C01) + CO2 (C02), simulated with use of the iterative computer program MATLAB.

Seismic Interpretation and Inversion Leading to an Accurate Reservoir Characterization in a Carbonate Environment

Seismic data acquired in the field show the subsurface reflectors or horizon among the geological strata, while the seismic inversion converts this reflector information into the acoustic impedance section which shows the layer properties based on lithology. The research aims to predict the porosity to identify the reservoir which is in between the tight layer. So, the output of the seismic inversion is much more batter than the seismic as it is closer to reality such as geology. Seismic inversion is frequently used to determine rock physics properties, for example, acoustic impedance and porosity.

The Importance of Expertly Evaluated Tests Underlined by COVID-19 Pandemic: A Mini Review

Background: The joint interest of clinicians and the laboratory test industry during the recent pandemic of the Coronavirus Disease 2019 (COVID-19) resulted in an explosion of accessible assays for COVID-19 serological testing. Content: The need of properly evaluated laboratory tests is more apparent today than ever before. Clinical application of the assay, analytical specifications, and performance convenience are the key criteria that must be followed while selecting an analytical method. An analytical evaluation is always performed before deciding to apply a procedure in the laboratory routine practice. Summary: Only after the evaluation, data collection, and analysis of the results in accordance with the established eligibility criteria can be concluded that the new assay is suitable for laboratory use.

A Single Nucleotide Polymorphism in the MMP9 Promoter Affects Lung Cancer and Clinicopathological Properties in Iranian Population

Background: Lung cancer is the most common cancer with 2,206,771 new cases in 2020 in worldwide. MMP9 is a member of matrix metalloproteinase family that is also known as gelatinase B or IV type collagenase (92KD). MMP9 through degrading of Extracellular Matrix (ECM) and releasing of growth factors has fundamental role in the tumorigenesis process. The C -1562 T SNP in the MMP9 promoter increases MMP9 expression and susceptibility to lung cancer. Then, the aim of this present case-control study was to investigate whether genetic variations of the MMP9 gene may constitute markers for lung cancer risk in males and in positive family history people in Iran. Methods: This is a case-control study including 120 lung cancer patients and 100 healthy controls. Polymorphism in the C -1562 T region was genotyped by PCR-RFLP assay. Odds Ratio (ORs) and 95% Confidence Intervals (CIs) were estimated by chi-square test from comparison of genotypes between lung cancer patients and healthy controls, using SPSS version 26.0. T-test and Image J software was also used. Results: The distribution of C-1562T genotype was significantly associated with the risk of lung cancer (Odds Ratio [OR] = 2.56, 95% Confidence Interval [CI] = 0.06-23.82). The further stratification analyses shown that males and patients with positive family history may increase risk of lung cancer. Conclusion: Our results indicated that the MMP9 C -1562 T polymorphism affects risk of lung cancer. In addition, men with T allele (OR = 3.94, CI = 1.47-10`.55) and patients with TT genotype and family history (OR = 2.18, CI = 1.03-4.59) exposure to higher risk of lung cancer.

Ecological Networks and Fluvial Corridors in Calabria (Southern Italy)

The anthropic pressure on natural systems is the main cause for the present process of biodiversity loss in terrestrial biosphere [1]. Really, the human disturbance on Earth affects the 74.1% of terrestrial and marine habitats, including 22.4% completely modified, 51.7% partially disturbed and just the 25.9% in natural and pristine conditions [2]. At the beginning of third millenium, in the middle of a post-industrial era, named “Anthropocene” [3], mankind is causing the greatest mass extinction of wildlife in terrestrial biosphere [4-6].

Medieval Scientific Policy in Medicine, Measuring Realism in Prophet Medicine

In dark days of Europe, which was a barren science, you saw the world through superstitions of alchemy and methods based on ignorance and speculation. A current of science emerged in medieval world that provided a new definition of science. In modern definition of science, it is knowledge of fixed truths of nature, man and society, which you have acquired with the tools of empirical intellect and by observation and induction, and which have been useful for ensuring the welfare and security of human beings. The background of this scientific current is call to reason, realism and philosophy. The intellect is source of knowledge of world, and the dimensions of the universe are based on principles of philosophy and method of realism. Sarton, leader of historiography of science in middle Ages, introduced Muslims as leaders of science in middle Ages. A collection of health, food, medicine and theoretical treatments is attributed to Muhammad, which has been published under the title of Prophetic Medicine. Ibn Khaldu criticized medicine of Prophet eight hundred years ago. he writes that Prophet was not a physician and a specialist in worldly affairs, and that use of Prophet's medicine does not require observance of status of prophethood The hypothesis of the present study is that despite Ibn Khaldun's criticism, the realism of the Prophet's medical works shows that Prophet's medicine needs new reflection and study, and a special type of medicine is based on trust in divine wisdom in creating an intelligent system between disease and medicine in nature. The present study has analyzed and explained realism in Prophet's medical words about fenugreek and has shown and proved it according to modern medical data. The Prophet issued a general decree regarding fenugreek and said; Hundreds of new laboratory and clinical research in medicine, veterinary medicine, agriculture, biology show general effectiveness of fenugreek in maintaining human health, livestock, nature and environment, and fenugreek is at heart of biology research, which Proves realism of comprehensive speech of Prophet.

The Physiological Profile of Male Professional Soccer Players: The Effect of Playing Division

The purpose of this study was to present the physiological profile of male soccer players who compete in the professional (Division [D] 1, 2, 3) and semi-professional (D4) Greek soccer leagues, and to compare their physiological profile according to playing division. Using 1,095 players (age: 25.2 ± 4.7 years), twelve anthropometric and physiological characteristics (age, height, body mass, BMI, VO2max, velocity of VO2max velocity at ventilatory threshold, maximum heart rate, maximum lactate, squat jump, 35 m sprint and sprinting fatigue index) were assessed. Factorial analysis of variance revealed a significantly (p < 0.05) enhanced physiological profile amongst the professional, compared to semi-professional players, for 10 of the 12 characteristics assessed between divisions. Regarding aerobic parameters, velocity at maximum oxygen uptake was the variable which discriminated professional, from semi-professional players most. With reference to anaerobic parameters, the 35m sprint was the variable which differentiated players between divisions (i.e. D1/D2 vs. D3/D4). Overall, findings in this study present the physiological profile of soccer players within the specified Greek soccer divisions, with differences identified between professional, and semi-professional divisions. These findings suggest that advanced physiological profiles may contribute to a player’s progression to higher divisions of Greek professional soccer.

Why Should Children Become Familiar with Nature

Until a few years ago, the world of Iranian children was often full of movement, mobility, and experience of nature, a real world in which nature and its landmarks, including soil, water, wind, living beings and tangible trees, and not limited to virtual image frames where even the possibility of experiencing and obtaining a simple and lasting memory such as playing soil is impossible and unattainable. Today, however, the vacancy of many childish games and mischievousness can be easily felt in green and open public spaces. Today's children look more strange and alienated in the face of nature than landlords. It is a fact that Iranian children are more familiar with their country's valuable animal and plant species such as gorasay, siberian dorrena, Asian cheetah, emperor salamander and manus boro alum, and animals such as zebras, African lions and elephants, polar bears, penguins and pandas. Who is this negligence from the other side? Why do not children spend as they should and perhaps in nature? Are limited and closed apartment spaces and the preference of computer games to group uplifting physical activities our children's choice? In this paper we review the importance of acquainting children with nature, with a focus on Iran.