Sickle cell anaemia: Awareness Among Health Professionals and medical students at the Lagos University Teaching Hospital, Lagos.

2010 ◽  
Vol 19 (4) ◽  
Author(s):  
B.A Animasahun ◽  
C.O Akitoye ◽  
O.F Njokanma
Keyword(s):  
Medical Students ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Health Professionals ◽  
Sickle Cell Anaemia ◽  
University Teaching

scholarly journals Assessment of serum Zinc, Copper and Selenium in non-symptomatic Sickle-Cell Anaemia patients at the University Teaching Hospital, Lusaka, Zambia

2021 ◽  
Vol 3 (2) ◽  
pp. 69-74
Author(s):  
Alfred Machiko ◽  
◽  
Trevor Kaile ◽  
Sumbukeni Kowa ◽  
Christopher Newton-Phiri ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Sickle Cell Anaemia ◽  
Serum Zinc ◽  
Binary Logistic Regression ◽  
Absorption Spectrometry ◽  
Serum Levels ◽  
Vital Role ◽  
University Teaching ◽  
The University

Background: Zinc, copper and selenium are known important trace elements playing a vital role as cofactors of enzymes such as superoxide dismutase and glutathione peroxide. They form part of the first line antioxidants enzymes in red blood cells and plasma. The study aimed at determining the serum levels of zinc, copper and selenium in asymptomatic sickle-cell anaemia patients. Methods: This was a case control study conducted from the specialist Haematology and Oncology Clinic 4 at the University Teaching Hospital, Lusaka, Zambia. 5mls of whole blood was collected from 46 sickle-cell anaemia patients and 46 healthy controls from Out-Patient Department after consent. Using Atomic Absorption Spectrometry, serum levels of zinc, copper and selenium was determined. Independent t-test was used to compare the means and a binary logistic regression for the likelihood of developing a sickling crisis, using SPSS version 20.Results: The mean serum levels of zinc in patients were lower 86.92±20.46mg/L against 91.33±43.23mg/L; p<0.028 of controls. Copper mean levels were 149.85±54.82mg/L against 134.32±54.16mg/L; p<0.191 of controls. Selenium mean levels were 0.100±0.041mg/L against 0.081±0.032mg/L; p<0.380 in patients compared to controls. The odds of developing one sickling crises in the past year given the levels of zinc, copper and selenium was [B = -.340, zinc Exp(B) =1.011, copper Exp(B) = 1.008, selenium Exp(B) = .000, DF = 1].Conclusion: Zinc is reduced in sickle-cell anaemia patients. The probability of developing a sickling crisis is lower in patients with higher serum levels of zinc and copper by 1.1% and 0.8% respectively.

scholarly journals Burden and Risk Factors of Chronic Kidney Disease in Children with Sickle Cell Anaemia Aged 5 – 16 Years at the University Teaching Hospital, Lusaka - Zambia

2020 ◽  
Vol 4 (3) ◽  
pp. 40-48
Author(s):  
Nchimunya Machila ◽  
◽  
Chishala Chabala ◽  
Chisambo Mwaba ◽  
Catherine Chunda-Liyoka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Sickle Cell Anaemia ◽  
Age At Diagnosis ◽  
University Teaching ◽  
Dipstick Urinalysis ◽  
The University

Background: Improved medical care has led to the improved life expectancy of sickle cell anaemia (SCA) patients hence complications associated with SCA such as chronic kidney disease (CKD) are being seen more frequently. Globally, nephropathy of varying severity occurs in 5 to 18 % of the SCA population across all age groups with a third of the adults proceeding to develop CKD while over 30 % of paediatric SCA patients have CKD in Africa. The mortality rate in SCA patients CKD is high. This study sought to determine the prevalence and risk factors of CKD in SCA, information that was not available in Zambia prior to this study. This information will guide in targeting and timing of screening for CKD in SCA in children in our population. Objectives: To determine the prevalence of haematuria, proteinuria, abnormal estimated glomerular filtration rate (eGFR), CKD, and risk factors of CKD among the steady-state SCA patients aged 5 to 16 years at the University Teaching Hospital (UTH), Lusaka. Methodology: This was a prospective cross-sectional study of 197 children aged 5 to 16 years with SCA at the UTH - Lusaka conducted from August 2014 to July 2015. Demographic and clinical data were collected using a structured questionnaire. Urine and blood samples were used to determine the urine albumin creatinine ratio (ACR) and full blood count /blood biochemistry respectively. CKD was defined and determined using the Kidney Disease Outcome Quality Initiative 2012 guidelines employing urine ACR, dipstick urinalysis and eGFR. In this study, spot urine ACR and dipstick urinalysis were done and repeated three months later if initial tests were abnormal. Data was analysed using SPSS version 21. Chi-square and t-test were used to compare proportions between groups. Relation between study variables and CKD were examined using logistic regression. Results: The mean age of the participants was 9.6 years (SD ±3.6). Male to female ratio was 1:1. The median age at diagnosis of SCA was 22 months (IQR = 44). The prevalence of haematuria, proteinuria and CKD among the study participants was 14.2%, 36% and 36 % respectively. Low haemoglobin and elevated mean corpuscular volume (MCV) were associated with CKD-AOR 0.62, 95% CI; 0.46-0.84 and 1.04, 95% CI; 1.01 – 1.08 respectively. Recurrent admissions (due to VOCs, severe anaemia and febrile illness) were also risk factors associated with CKD- AOR 0.52, 95% CI; 0.27-0.98. CKD was not associated with age at enrolment, sex, age at diagnosis of SCA, recurrent Vaso-occlusive crisis (VOCs) or abnormal liver function tests. Conclusion: The prevalence of CKD among the SCA patients at UTH- Lusaka is high (36%) with lower Haemoglobin, elevated MCV and recurrent admissions being risk factors for developing CKD. SCA patients should be screened for CKD routinely at least once a year. Interventions such as the early introduction of hydroxyurea, proactive blood transfusions and ACE inhibitors can reduce the risk of CKD and its progression to end-stage renal disease.

Haemoglobin F and A2profiles among sickle cell anaemia patients in Lagos State University Teaching Hospital (LASUTH), Nigeria

2018 ◽  
Vol 9 (1) ◽  
pp. 26
Author(s):  
Akinsegun Akinbami ◽  
Ebele Uche ◽  
Adedoyin Dosunmu ◽  
Bodunrin Osikomaiya ◽  
Adewumi Adediran ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Sickle Cell Anaemia ◽  
University Teaching ◽  
State University ◽  
Lagos State

scholarly journals Ovarian Reserve in Nigerian Women with Sickle Cell Anaemia: A Cross-Sectional Study.

2021 ◽  
Author(s):  
Sunusi-Rimi Rimi Garba ◽  
Christian Chigozie Makwe ◽  
Vincent Oluseye Osunkalu ◽  
Olufunto Olufela Kalejaiye ◽  
Adaiah Priscillia Soibi-Harry ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Ovarian Reserve ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Health Clinic ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nigerian Women

Abstract Introduction: Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia has been inconsistent.Aim and objective: The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital.Study Design: This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital.Methodology: A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age; 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotypes of each participant were determined on alkaline electrophoresis (pH 8.4) before analysis. serum Anti-Mullerian Hormone (AMH) were determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T).Results: The mean ± SD serum Anti-Mullerian Hormone (AMH) level in women with HbSS 3.64 ± 0.65 ng/mL was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA.Conclusion: The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.

scholarly journals Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sunusi Rimi Garba ◽  
Christian Chigozie Makwe ◽  
Vincent Oluseye Osunkalu ◽  
Olufunto Olufela Kalejaiye ◽  
Adaiah Priscillia Soibi-Harry ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Ovarian Reserve ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Health Clinic ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nigerian Women

Abstract Introduction Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent. Aim and objective The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital. Study Design This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital. Methodology A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T). Results The mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA. Conclusion The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.

scholarly journals Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

2020 ◽  
Vol 1 (6) ◽  
pp. 175-181
Author(s):  
Raymond Mpanjilwa Musowoya ◽  
Patrick Kaonga ◽  
Alick Bwanga ◽  
Catherine Chunda-Lyoka ◽  
Christopher Lavy ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Clinical Manifestations ◽  
Classification Systems ◽  
University Teaching ◽  
Cell Disease ◽  
Tertiary Teaching ◽  
Musculoskeletal Manifestations

Aims Sickle cell disease (SCD) is an autosomal recessive inherited condition that presents with a number of clinical manifestations that include musculoskeletal manifestations (MM). MM may present differently in different individuals and settings and the predictors are not well known. Herein, we aimed at determining the predictors of MM in patients with SCD at the University Teaching Hospital, Lusaka, Zambia. Methods An unmatched case-control study was conducted between January and May 2019 in children below the age of 16 years. In all, 57 cases and 114 controls were obtained by systematic sampling method. A structured questionnaire was used to collect data. The different MM were identified, staged, and classified according to the Standard Orthopaedic Classification Systems using radiological and laboratory investigations. The data was entered in Epidata version 3.1 and exported to STATA 15 for analysis. Multiple logistic regression was used to determine predictors and predictive margins were used to determine the probability of MM. Results The cases were older median age 9.5 (interquartile range (IQR) 7 to 12) years compared to controls 7 (IQR 4 to 11) years; p = 0.003. After multivariate logistic regression, increase in age (adjusted odds ratio (AOR) = 1.2, 95% confidence interval (CI) 1.04 to 1.45; p = 0.043), increase in the frequency of vaso-occlusive crisis (VOC) (AOR = 1.3, 95% CI 1.09 to 1.52; p = 0.009) and increase in percentage of haemoglobin S (HbS) (AOR = 1.18, 95% CI 1.09 to 1.29; p < 0.001) were significant predictors of MM. Predictive margins showed that for a 16-year-old the average probability of having MM would be 51 percentage points higher than that of a two-year-old. Conclusion Increase in age, frequency of VOC, and an increase in the percentage of HbS were significant predictors of MM. These predictors maybe useful to clinicians in determining children who are at risk. Cite this article: Bone Joint Open 2020;1-6:175–181.

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